Advanced Science, EarlyView.Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki +7 more
wiley +1 more source
<i>Pseudomonas aeruginosa</i> biofilm-deficient mutants undergo parallel evolution during chronic infection. [PDF]
J BacteriolGloag ES +6 more
europepmc +1 more source
Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution
Advanced Science, EarlyView.This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida +4 more
wiley +1 more source
A Nano-SiO<sub>2</sub>-Based Core-Shell Hybrid as a Dual-Functional Viscosity Reducer and Pour Point Depressant for Heavy Oil. [PDF]
Polymers (Basel)Ji B +8 more
europepmc +1 more source
Polysiloxane‐Based Single‐Ion Conducting Polymer Electrolyte for Sodium Batteries
Advanced Science, EarlyView.We report a polysiloxane‐based single‐ion conducting polymer electrolyte for sodium batteries. This polymer electrolyte exhibits high Na+ ion mobility and a wide electrochemical stability window, enabling the long‐term stable cycling of various cathode chemistries – also at room temperature, elevated dis‐/charge rates and active material mass loadings,
Yixuan Guo +7 more
wiley +1 more source
Multi-omics of barley Fusarium Head Blight converge on pathogen-triggered biosynthesis of aromatic amino acid derived chemical defense compounds. [PDF]
Stress BiolHein S +8 more
europepmc +1 more source
Advanced Science, EarlyView.This study demonstrates, for the first time, the use of a large‐format high‐pressure press to modify synthesized Li2SrSiO4:Eu2+,Cs+ phosphors after its preparation. The pressure treatment results in the formation of new materials with distinctive optical properties, opening pathways for the development of advanced LED devices and high‐performance ...
Przemysław Woźny +9 more
wiley +1 more source
Correction: Synergistic design of gadolinium-doped polyaniline/MWCNT hybrid nanocomposites for high-performance supercapacitors. [PDF]
Sci RepDominic J +6 more
europepmc +1 more source
Advanced Science, EarlyView.A hybrid biomechanical–electromagnetic energy‐harvesting e‐skin is developed using a gelatin‐based outer matrix with a zwitterionic conductive inner layer. The e‐skin autonomously generates stable electrical stimulation from daily body motion and ambient electronics, enabling significantly enhanced wound healing bothin vitro and in vivo.
Syun‐Hong Chou +12 more
wiley +1 more source
Intercostal nerve blocks should set the standard for regional analgesia in video-assisted thoracic surgery. [PDF]
J Thorac DisCoppens S.
europepmc +1 more source