Results 31 to 40 of about 114,809 (134)

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Security challenges of Small Cell as a Service in virtualized mobile edge computing environments [PDF]

, 2016
Research on next-generation 5G wireless networks is currently attracting a lot of attention in both academia and industry. While 5G development and standardization activities are still at their early stage, it is widely acknowledged that 5G systems are ...
Haralambos Mouratidis, Vasilakis, Vasileios, Panaousis, Emmanouil, Vassilakis, Vassilios, Emmanouil Panaousis, Mouratidis, Haralambos, Vassilios Vassilakis   +6 more
core   +1 more source

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Tip60‐Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC

Advanced Science, EarlyView.
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Fang Zhen, Hongyi Wang, Ningzhi Zhang, Le Wang, Huiyuan Tian, Luxi Kang, Zhanpeng Liu, Jing Hu   +7 more
wiley   +1 more source

5G Innovations for New Business Opportunities

, 2017
International audience5G is the next generation mobile network that enables innovation and supports progressive change across all vertical industries and across our society .
Queseth, Olav, Surridge, Mike, Giustiniano, Domenico, Manzalini, Antonio, Rokkas, Theodoros, Bedo, Jean-Sébastien, Iovanna, Paola, Tjelta, Terje, Gavras, Anastasius, El Ayoubi, Salah Eddine, Sébastien Bedo, Jean, Bedo, Jean Sebastien, Elayoubi, Salah Eddine, Surridge, Michael, Filippou, Miltiades, Filippou, Miltiadis, Eddine El Ayoubi, Salah   +16 more
core   +1 more source

The BTB/POZ‐MATH Protein ZmBPM1 Interacts With Autophagy‐related Protein ZmATG6 and Modulates the NLR Protein Rp1‐D21‐Mediated Defense Response in Maize

Advanced Science, Volume 13, Issue 61, 3 November 2026.
The maize BTB/POZ‐MATH (BPM) protein ZmBPM1 interacts with autophagy‐related protein ZmATG6 to relocate the NLR protein Rp1‐D21 from the nucleo‐cytoplasmic compartment into autophagosome‐like puncta, leading to autophagy‐mediated turnover and suppressing the hypersensitive response.
Chang‐Xiao Tang, Tong‐Tong Liu, Qi‐Dong Ge, Xiao‐Ying Liu, Wanxiao Wang, Yang Sun, Yanfei Liu, Faqiang Li, Guan‐Feng Wang   +8 more
wiley   +1 more source

5G EVE European Validation Platform for extensive Trials at CoNEXT EM-5G

, 2018
The presentation outlines project 5G EVE, which supports the fundamental transition to the future 5G network infrastructure by offering to vertical industries and to all 5G PPP Phase3 projects, facilities to validate their network and services KPIs. The
AGUS Mauro (6332990), BOLDI Mauro (6332993), AGUS Mauro, BOLDI Mauro   +3 more
core   +1 more source

Converging GWAS and Genome Editing Decrypts MsCBF8‐MsGolS2 Regulatory Module for Drought Tolerance Without Yield Penalty in Medicago sativa

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5967-5984, November 2026.
ABSTRACT Drought constitutes a major abiotic stress limiting alfalfa productivity. To elucidate the genetic basis of drought tolerance, a genome‐wide association study (GWAS) was conducted in alfalfa, which identified a CBF/DREB1 family transcription factor designated MsCBF8.
Yangyang Zhang, Xueqian Jiang, Tian Zhang, Huajuan Leng, Jing Cui, Xu Jiang, Lili Zhang, Zhen Wang, Tiejun Zhang, Qingchuan Yang, Xue Wang, Junmei Kang   +11 more
wiley   +1 more source

Network Applications (NetApps) as a 5G booster for Transport & Logistics (T&L) Services : the VITAL-5G approach

, 2022
: By delivering end-to-end latencies down to 5ms, data rates of up to 20Gbps, and ultra-high reliability of 99.999%, 5G is extending the capabilities of numerous industry verticals, including the Transport & Logistics (T&L).
Trichias, Konstantinos, Kotinas, Ilias, Carlan, Valentin, Vulpe, Alexandru, Brenes, Juan, Suciu, George, Municio, Esteban, Landi, Giada, Ropodi, Athina, Marquez-Barja, Johann, Marquez-Barja, Johann M., Alexandru Vulpe, Konstantinos Trichias, Nina Slamnik-Krijestorac, George Suciu, Johann M. Marquez-Barja, Athina Ropodi, Valentin Carlan, Juan Brenes, Esteban Municio, Slamnik-Krijestorac, Nina, Ilias Kotinas, Giada Landi   +22 more
core   +1 more source

Auto‐Downregulation of the Florigen FT Production Prevents Precocious Flowering in Plants

Advanced Science, Volume 13, Issue 55, 5 October 2026.
This study shows that the leaf vein‐expressed FD complexes with the florigen FT to bind DNA motifs in FT promoter, which antagonizes CONSTANS‐mediated FT activation to feedback down‐regulate FT expression. This prevents an excessive induction of FT expression by inductive photoperiods, thereby precluding precocious transition to flowering in ...
Shu Tian, Xiao Luo, Bowen Cui, Yuehui He
wiley   +1 more source