Results 61 to 70 of about 628,388 (295)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

A Survey of Self-Interference Management Techniques for Single Frequency Full Duplex Systems

IEEE Access, 2018
This paper presents a comprehensive survey of the literature on self-interference management schemes required to achieve a single frequency full duplex (FD) communication in wireless communication networks.
Chinaemerem David Nwankwo, Lei Zhang, Atta Quddus, Muhammad Ali Imran, Rahim Tafazolli   +4 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

A Measurement-Based Power Consumption Model for Networks With Intelligent Control (RIC)

IEEE Open Journal of the Communications Society
Open Radio Access Network (Open RAN) triggers a shift towards multi-vendor deployments with increased programmability, flexibility, and intelligence. Still, several critical questions remain unanswered, particularly regarding Open RAN's impact on power ...
Joao Paulo S. H. Lima, George N. Katsaros, Rahim Tafazolli, Konstantinos Nikitopoulos   +3 more
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Enhancing 5G propagation into vehicles and buildings using optically transparent and polarisation insensitive metasurfaces over wide-incidence angles

Scientific Reports
This article introduces two transmissive metasurfaces applied to normal windows, aiming to improve the 5G outdoor-to-indoor (O2I) coverage. These windows can be utilized in various settings, such as vehicles or buildings.
Amirmasood Bagheri, Shadi Danesh, Fan Wang, Seyed Ehsan Hosseininejad, Mohsen Khalily, Rahim Tafazolli   +5 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Polarisation reconfigurable anisotropic dielectric resonator antenna

Scientific Reports
A novel polarization reconfigurable anisotropic dielectric resonator antenna (ADRA) is presented utilizing a new modulation scheme to exploit the degree of freedom in the polarization domain.
Shadi Danesh, Mohammad Abedian, Mohsen Khalily, Pei Xiao, Rahim Tafazolli, Ahmed A. Kishk   +5 more
doaj   +1 more source

Acquisition performance of B1I abounding with 5G signals [PDF]

, 2022
Peng Shang, Xue Wang, Decai Zou, Ziyue Chu, Yao Guo   +4 more
openalex   +1 more source