Results 81 to 90 of about 41,879 (269)

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Active Gain-Controlled Beam-Steering Transmissive Surface

IEEE Open Journal of Antennas and Propagation
Engineered electromagnetic surfaces enable enhancing the strength of a signal in the desired direction(s) using anomalous reflection/transmission. However, to boost the gain of the conventional surfaces, the common solution is to increase its aperture ...
Seyed Ehsan Hosseininejad, Amirmasood Bagheri, Fan Wang, Mohsen Khalily, Rahim Tafazolli   +4 more
doaj   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Time-modulated 1-bit amplitude-coded metasurface for space-frequency beam shaping

Scientific Reports
Two-dimensional (2D) space-encoded metamaterials enable the progressive development of a multitude of functionalities for controlling electromagnetic (EM) waves. Recently, time-modulated phase-coded metasurfaces have been introduced into 2D metamaterials,
Seyed Ehsan Hosseininejad, Mohsen Khalily, Rahim Tafazolli   +2 more
doaj   +1 more source

Caterpillar RLNC (CRLNC): A Practical Finite Sliding Window RLNC Approach

IEEE Access, 2017
Random linear network coding (RLNC) is a popular coding scheme for improving communication and content distribution over lossy channels. For packet streaming applications, such as video streaming and general IP packet streams, recent research has shown ...
Simon Wunderlich, Frank Gabriel, Sreekrishna Pandi, Frank H. P. Fitzek, Martin Reisslein   +4 more
doaj   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Low-Complexity Hybrid Beamforming for Massive MIMO Systems in Frequency-Selective Channels

IEEE Access, 2019
Hybrid beamforming for frequency-selective channels is a challenging problem, as the phase shifters provide the same phase shift to all the subcarriers.
Sohail Payami, Mathini Sellathurai, Konstantinos Nikitopoulos   +2 more
doaj   +1 more source

Photonic Time Crystals and Time‐Varying Electromagnetic Metamatter: A New Direction for Ultrafast Tunable Photonic and Microwave Materials and Devices

Advanced Science, EarlyView.
Photonic time crystals (PTCs) are systems in which electromagnetic parameters are modulated periodically in time, producing momentum bandgaps via temporal scattering rather than spatial Bragg processes. This review examines the theoretical frameworks, modeling, and computational tools for time‐varying media, and summarizes experimental demonstrations ...
Ranjan Kumar Patel, Shriram Ramanathan, Ronald P. Jenkins, Michael J. Carter   +3 more
wiley   +1 more source

5G Communications: Energy Efficiency [PDF]

Mobile Information Systems, 2017
Konstantinos P. Demestichas, Evgenia F. Adamopoulou, Michal Choras   +2 more
openaire   +1 more source

vBerlinV2N: Recreating a Cellular Network Measurement Campaign With Simulations

IEEE Access
System-level simulations play a crucial role in evaluating the behaviors of cellular networks, yet most studies rely on synthetic simulation scenarios rather than reproducing realistic network deployments.
Christian L. Vielhaus, Mauri Seidel, Vincent Latzko, Alexander Grob, Peter Sossalla, Martin Reisslein, Frank H. P. Fitzek   +6 more
doaj   +1 more source