Results 121 to 130 of about 10,421 (201)

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

open access: yesAdvanced Science, Volume 13, Issue 4, 19 January 2026.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang   +6 more
wiley   +1 more source

Predicting Immunotherapy Outcomes in NSCLC Using RNA and Pathology from Multicenter Clinical Trials

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
LIRA, a machine learning‐based model, is developed using transcriptomic data from 891 NSCLC patients in the OAK and POPLAR cohorts. Its predictive performance is validated in multiple external cohorts. Patients stratified by LIRA‐score exhibit distinct clinical characteristics and tumor microenvironment profiles.
Zhaojun Wang   +32 more
wiley   +1 more source

Rattan‐Based Solar Evaporator Hits 3.34 Kg·M−2·h−1 and Long‐Term Salt Resistance via Programmed Carbonization

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
A rattan‐based evaporator with bimodal hierarchical porous structures achieves an high evaporation rate of 3.34 kg m−2 h−1 under 1 sun illumination by optimizing the surface water layer, localizing heat, and reducing vaporization enthalpy. Abstract Global water scarcity urgently demands sustainable purification solutions.
Shanshan Jia   +13 more
wiley   +1 more source

Compartmentalization and Aggregation of Biomolecular Condensates in Crowded Hydrogels for Enhanced Nucleic Acid Diagnosis

open access: yesAdvanced Science, Volume 13, Issue 3, 14 January 2026.
A cell‐mimetic hydrogel compartment is proposed to enhance the efficiency of enzymatic reactions. The naturally porous structure of a crowded hydrogel can simulate the intracellular microenvironment, promoting the aggregation of biomolecules and activity of DNA polymerase through excluded volume effects and compartmentalization.
Fangbin Xiao   +3 more
wiley   +1 more source

How 5G NR Signals Impact on the Response of Broadband Electric Field Probes

open access: hybrid, 2022
Sara Adda   +4 more
openalex   +1 more source

Aquaporin‐4 and caveolin‐1 as mediators of fibrinogen‐driven cerebrovascular pathology in cerebral amyloid angiopathy

open access: yesAlzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION Cerebral amyloid angiopathy (CAA), marked by amyloid beta (Aβ) accumulation in perivascular spaces (PVSs), contributes to vascular injury and inflammation in Alzheimer's disease. The mechanisms underlying CAA‐related vascular pathology remain unclear.
Vishal Singh   +7 more
wiley   +1 more source

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