Results 91 to 100 of about 41,410 (250)

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Stability and Expression of Selected miRNAs, circRNAs, and rRNAs in Swiss Albino Mice Tissues to Preditc Port-Mortem Interval

Brazilian Journal of Forensic Sciences, Medical Law and Bioethics
In forensics, post-mortem interval (PMI) estimation is essential. Researchers have devised various approaches to accurately determine PMI, consequently, ribonucleic acid (RNA) molecules could be useful PMI estimation tool.
Onyekachi Ogbonnaya Iroanya, Tochukwu Frank Egwuatu, Adedolapo Meshach Adebajo, Solomon Tornnee Aloku, David Chima Uche, Stephania Semiire Folorunso   +5 more
doaj   +1 more source

Molecular cytogenetic differentiation of paralogs of Hox paralogs in duplicated and re-diploidized genome of the North American paddlefish (Polyodon spathula). [PDF]

, 2017
BackgroundAcipenseriformes is a basal lineage of ray-finned fishes and comprise 27 extant species of sturgeons and paddlefishes. They are characterized by several specific genomic features as broad ploidy variation, high chromosome numbers, presence of ...
Amemiya, Chris T, Flajšhans, Martin, Gela, David, Havelka, Miloš, Howell, William Mike, Kořínková, Tereza, Ráb, Petr, Symonová, Radka   +7 more
core   +4 more sources

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, Volume 13, Issue 1, 5 January 2026.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source

Chromosomal diversification in ribosomal DNA sites in Ancistrus Kner, 1854 (Loricariidae, Ancistrini) from three hydrographic basins of Mato Grosso, Brazil

Comparative Cytogenetics, 2011
Populations of seven Ancistrus species were analyzed from streams and rivers of three hydrographic Brazilian basins. All populations showed different diploid numbers (2n), fundamental numbers (FNs), and karyotypes.
Sandra Mariotto, Liano Centofante, Marcelo Vicari, Roberto Artoni, Orlando Moreira Filho   +4 more
doaj   +1 more source

Reconstitution of the complete pathway of ITS2 processing at the pre-ribosome

, 2017
Removal of internal transcribed spacer 2 (ITS2) from pre-ribosomal RNA is essential to make functional ribosomes. This complicated processing reaction begins with a single endonucleolytic cleavage followed by exonucleolytic trimming at both new cleavage ...
Conti, E., Falk, S., Flemming, D., Fromm, L., Hurt, E., Schuller, J., Thoms, M.   +6 more
core   +2 more sources

Mitochondrial Genome Engineering: The Revolution May Not Be CRISPR-Ized. [PDF]

, 2018
In recent years mitochondrial DNA (mtDNA) has transitioned to greater prominence across diverse areas of biology and medicine. The recognition of mitochondria as a major biochemical hub, contributions of mitochondrial dysfunction to various diseases, and
Gammage, Payam A, Minczuk, Michal, Moraes, Carlos T   +2 more
core   +1 more source

Mitochondrial DNA Variation in the Aging Human Cerebral Cortex and Cerebellum

Aging Cell, Volume 25, Issue 1, January 2026.
We used cerebellum and frontal cortex whole genome sequencing data from the North American Brain Expression Consortium to investigate mitochondrial DNA deletions, single nucleotide variants, and copy number. We found significant differences between brain regions and age effects for all these metrics, which illustrate mitochondrial changes in healthy ...
Audrey A. Omidsalar, David R. Tyrpak, J. Andrew MacKay, Kelvin Yen, Pinchas Cohen, Geidy Serrano, Thomas G. Beach, Michael A. Nalls, Dena G. Hernandez, Mark R. Cookson, Andrew B. Singleton, J. Raphael Gibbs, North American Brain Expression Consortium, Brooke E. Hjelm   +13 more
wiley   +1 more source

Chromosomal diversification and karyotype evolution of diploids in the cytologically diverse genus Prospero (Hyacinthaceae) [PDF]

, 2013
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work ...
Andrew R Leitch, Eva M Temsch, Franz Speta, Hanna Weiss-Schneeweiss, Jang, Tae-Soo, John Parker, Khatere Emadzade, Tae-Soo Jang   +7 more
core   +2 more sources

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, Volume 599, Issue 24, Page 3669-3684, December 2025.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source