Results 221 to 230 of about 41,410 (250)

Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two Mechanisms

Nucleic Acid Therapeutics, 2020
In this study, we demonstrate that 5S ribosomal RNA (rRNA), a highly structured and protein-bound RNA, is quite difficult to reduce with antisense oligonucleotides (ASOs). However, we found a single accessible site that was targetable with a high-affinity complementary ASO. The ASO appeared to bind to the site, recruit RNaseH1, and cause degradation of
Adam J, Pollak, Justin H, Hickman, Xue-Hai, Liang, Stanley T, Crooke   +3 more
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Nucleocytoplasmic transport of 5S ribosomal RNA

Seminars in Cell & Developmental Biology, 1997
Nucleocytoplasmic transport of 5S ribosomal RNA in Xenopus oocytes occurs in the context of small, non-ribosomal RNPs. The complex with the zinc finger protein TFIIIA (7S RNP) is exported from the nucleus and stored in the cytoplasm, whereas the complex with the ribosomal protein L5 (5S RNP) shuttles between the nucleus and the cytoplasm.
T, Pieler, F, Rudt
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Comparative studies on bacterial 5S ribosomal RNA

Archives of Biochemistry and Biophysics, 1973
Abstract The 5S rRNAs of Escherichia coli , Bacillus stearothermophilus , and B. subtilis were isolated and their molecular conformation examined. All three 5S rRNAs were similar with regard to nucleotide chain length, base composition and general configuration.
P N, Gray, G F, Saunders
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A proposed role for 5S ribosomal RNA

Biochemical and Biophysical Research Communications, 1973
Abstract Cytoplasmic ribosomes show protein-synthesizing activity with degraded large and small rRNA's, but only if 5S RNA is intact.
N G, Avadhani, D E, Buetow
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Promoter region for yeast 5S ribosomal RNA

Nature, 1977
WE have sequenced the DNA region immediately preceding the structural gene for the 5S ribosomal RNA of yeast (Saccharomyces cerevisiae). Since the 5S RNA, a component of the larger ribosomal subunit, has a 5′ triphosphate1,2, this molecule is likely to be the direct product of the gene, unmodified by maturation at the 5′ end.
A M, Maxam, R, Tizard, K G, Skryabin, W, Gilbert   +3 more
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Role of 5S ribosomal RNA in polypeptide synthesis. II. Dissociation of 5S ribosomal RNA from 50S ribosomes in Escherichiacoli

Biochemical and Biophysical Research Communications, 1968
SOS ribosomes obtained from E. coli were dissociated into 5s rRNA and -44s particles in which at least one of the protein components was missing. Dissociation was produced by dialysis vs. 0.5 M NH4Cl in Mg++-free medium and the resulting 44s particles were isolated by centrifugation through Mg’+-free sucrose solution.
M A, Siddiqui, K, Hosokawa
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The nucleotide sequence of chicken 5S ribosomal RNA

Journal of Molecular Evolution, 1974
The nucleotide sequence of the 5S ribosomal RNA of somatic cells of the chicken (Gallus gallus) differs from that of other vertebrates thus far examined. Besides base substitutions, alterations include two nucleotide deletions and two additions.
N R, Pace, T A, Walker, B, Pace, R L, Erikson   +3 more
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Role of 5S ribosomal RNA in polypeptide synthesis

Biochemical and Biophysical Research Communications, 1969
50S ribosomes obtained from Escherichia coli dissociated by dialysis into 5S rRNA and 44S particles, noting partially uncoiled ...
M A, Siddiqui, K, Hosokawa
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Interaction between Escherichia coli ribosomal proteins and 5S RNA molecules : recognition of prokaryotic 5S RNAs and rejection of eukaryotic 5S RNAs

Biochimie, 1973
Summary A specific binding test (incorporation into E. coli ribosomal subunits reconstituted from lithium cores and lithium supernatant) was used to assay the degree of structural homology between 5S RNA molecules from different origins. The two procaryotic molecules tested are recognized to some extent by the system, but none of the six eukaryotic ...
G, Bellemare, R, Vigne, B R, Jordan
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Transcription of Xenopus 5S ribosomal RNA genes

Nature, 1982
The accurate transcription of 5S RNA genes when injected into the nucleus of Xenopus oocytes or when added to an in vitro transcription system has allowed identification of the DNA sequences and one of the protein factors required for 5S RNA synthesis.
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