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Nucleic Acid Therapeutics, 2020
In this study, we demonstrate that 5S ribosomal RNA (rRNA), a highly structured and protein-bound RNA, is quite difficult to reduce with antisense oligonucleotides (ASOs).
Adam J. Pollak+3 more
semanticscholar +4 more sources
In this study, we demonstrate that 5S ribosomal RNA (rRNA), a highly structured and protein-bound RNA, is quite difficult to reduce with antisense oligonucleotides (ASOs).
Adam J. Pollak+3 more
semanticscholar +4 more sources
The conformation of loop E of eukaryotic 5S ribosomal RNA.
Biochemistry, 1993The solution structure of a 27-nucleotide duplex, including the internal loop E from Xenopus laevis 5S ribosomal RNA, has been studied by two-dimensional NMR spectroscopy, followed by restrained molecular dynamics.
B. Wimberly, G. Varani, I. Tinoco
semanticscholar +4 more sources
Promoter region for yeast 5S ribosomal RNA
Nature, 1977WE have sequenced the DNA region immediately preceding the structural gene for the 5S ribosomal RNA of yeast (Saccharomyces cerevisiae). Since the 5S RNA, a component of the larger ribosomal subunit, has a 5′ triphosphate1,2, this molecule is likely to be the direct product of the gene, unmodified by maturation at the 5′ end.
A. Maxam+3 more
semanticscholar +4 more sources
Biomacromolecules, 2000
Ribosomes have been visualized in electron micrographs in 1943 but 5S rRNA was discovered 20 years later. The next four decades witnessed big advances in our understanding of the ribosome using biochemical, genetic and low resolution structural approaches.
Miroslawa Z. Barciszewska+3 more
openaire +3 more sources
Ribosomes have been visualized in electron micrographs in 1943 but 5S rRNA was discovered 20 years later. The next four decades witnessed big advances in our understanding of the ribosome using biochemical, genetic and low resolution structural approaches.
Miroslawa Z. Barciszewska+3 more
openaire +3 more sources
A proposed role for 5S ribosomal RNA
Biochemical and Biophysical Research Communications, 1973Abstract Cytoplasmic ribosomes show protein-synthesizing activity with degraded large and small rRNA's, but only if 5S RNA is intact.
D.E. Buetow, N.G. Avadhani
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Nucleocytoplasmic transport of 5S ribosomal RNA
Seminars in Cell & Developmental Biology, 1997Nucleocytoplasmic transport of 5S ribosomal RNA in Xenopus oocytes occurs in the context of small, non-ribosomal RNPs. The complex with the zinc finger protein TFIIIA (7S RNP) is exported from the nucleus and stored in the cytoplasm, whereas the complex with the ribosomal protein L5 (5S RNP) shuttles between the nucleus and the cytoplasm.
Falko Rudt, Tomas Pieler
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Comparative studies on bacterial 5S ribosomal RNA
Archives of Biochemistry and Biophysics, 1973Abstract The 5S rRNAs of Escherichia coli , Bacillus stearothermophilus , and B. subtilis were isolated and their molecular conformation examined. All three 5S rRNAs were similar with regard to nucleotide chain length, base composition and general configuration.
Grady F. Saunders, Peter N. Gray
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Transcription of Xenopus 5S ribosomal RNA genes [PDF]
The accurate transcription of 5S RNA genes when injected into the nucleus of Xenopus oocytes or when added to an in vitro transcription system has allowed identification of the DNA sequences and one of the protein factors required for 5S RNA synthesis.
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The Evolutionary History of the Structure of 5S Ribosomal RNA
Journal of Molecular Evolution, 20095S rRNA is the smallest nucleic acid component of the large ribosomal subunit, contributing to ribosomal assembly, stability, and function. Despite being a model for the study of RNA structure and RNA-protein interactions, the evolution of this universally conserved molecule remains unclear. Here, we explore the history of the three-domain structure of
Gustavo Caetano-Anollés+2 more
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