Results 71 to 80 of about 17,790 (205)

RNA N4‐acetylcytidine modification and its role in health and diseases

MedComm, Volume 6, Issue 1, January 2025.
N4‐acetylcytidine (ac4C) modification is a crucial RNA modification widely present in eukaryotic RNA. This review first outlines the latest research advancements on the roles and mechanisms of ac4C modification in both health and disease and explores ac4C‐targeted therapies with the aim of advancing cancer research and improving patient outcomes ...
Qiang Wang, Yixiao Yuan, Qiang Zhou, YingDong Jia, Jing Liu, GuangJun Xiao, Chunhong Li, Xiulin Jiang   +7 more
wiley   +1 more source

Stability and Expression of Selected miRNAs, circRNAs, and rRNAs in Swiss Albino Mice Tissues to Preditc Port-Mortem Interval

Brazilian Journal of Forensic Sciences, Medical Law and Bioethics
In forensics, post-mortem interval (PMI) estimation is essential. Researchers have devised various approaches to accurately determine PMI, consequently, ribonucleic acid (RNA) molecules could be useful PMI estimation tool.
Onyekachi Ogbonnaya Iroanya, Tochukwu Frank Egwuatu, Adedolapo Meshach Adebajo, Solomon Tornnee Aloku, David Chima Uche, Stephania Semiire Folorunso   +5 more
doaj   +1 more source

Chromosomal diversification in ribosomal DNA sites in Ancistrus Kner, 1854 (Loricariidae, Ancistrini) from three hydrographic basins of Mato Grosso, Brazil

Comparative Cytogenetics, 2011
Populations of seven Ancistrus species were analyzed from streams and rivers of three hydrographic Brazilian basins. All populations showed different diploid numbers (2n), fundamental numbers (FNs), and karyotypes.
Sandra Mariotto, Liano Centofante, Marcelo Vicari, Roberto Artoni, Orlando Moreira Filho   +4 more
doaj   +1 more source

Reference genes for real-time PCR quantification of microRNAs and messenger RNAs in rat models of hepatotoxicity. [PDF]

PLoS ONE, 2012
Hepatotoxicity is associated with major changes in liver gene expression induced by xenobiotic exposure. Understanding the underlying mechanisms is critical for its clinical diagnosis and treatment.
María N Lardizábal, Ana L Nocito, Stella M Daniele, Leonardo A Ornella, Javier F Palatnik, Luis M Veggi   +5 more
doaj   +1 more source

PCBP1/2 and TDP43 Function as NAT10 Adaptors to Mediate mRNA ac4C Formation in Mammalian Cells

Advanced Science, Volume 11, Issue 47, December 18, 2024.
Poly(rC)‐binding protein 1/2 (PCBP1/2) and TAR DNA binding protein 43 (TDP43) function as NAT10 adaptors for mRNA acetylation in mammalian cells. These adaptors are responsible for substrate tethering and selection. Loss of the adaptors results in decreased mRNA acetylation abundance and ablated cytidine‐rich ac4C motifs. The presence of the NAT10/PCBP/
Zhi‐Yan Jiang, Yu‐Ke Wu, Zuo‐Qi Deng, Lu Chen, Yi‐Min Zhu, Yuan‐Song Yu, Hong‐Bo Wu, Heng‐Yu Fan   +7 more
wiley   +1 more source

Comprehensive lung microbial gene and genome catalogs assist the mechanism survey of Mesomycoplasma hyopneumoniae strains causing pig lung lesions

iMeta, Volume 3, Issue 6, December 2024.
In this study, we utilized 744 metagenomic sequencing data from lower respiratory tract microbial samples of 675 well‐phenotyped pigs across five cohorts. From these, we constructed a microbial gene catalog containing 10,031,593 nonredundant genes and 356 metagenome‐assembled genomes (MAGs), which were further clustered into 256 species‐level genome ...
Jingquan Li, Fei Huang, Yunyan Zhou, Tao Huang, Xinkai Tong, Mingpeng Zhang, Jiaqi Chen, Zhou Zhang, Huipeng Du, Zifeng Liu, Meng Zhou, Yiwen Xiahou, Huashui Ai, Congying Chen, Lusheng Huang   +14 more
wiley   +1 more source

Extraction of total RNA from single-oocytes and single-cell mRNA sequencing of swine oocytes

BMC Research Notes, 2018
Objective Analyses of single oocytes are essential for a fine dissection of molecular features governing developmental competence. We adapted the phenol–chloroform procedure for the purification of total RNA from single oocytes. Results Key modifications
Katelyn M. Kimble, Sarah E. Dickinson, Fernando H. Biase   +2 more
doaj   +1 more source

Analyzing the role of ferroptosis in ribosome‐related bone marrow failure disorders: From pathophysiology to potential pharmacological exploitation

IUBMB Life, Volume 76, Issue 12, Page 1011-1034, December 2024.
Abstract Within the last decade, the scientific community has witnessed the importance of ferroptosis as a novel cascade of molecular events leading to cellular decisions of death distinct from apoptosis and other known forms of cell death. Notably, such non‐ apoptotic and iron‐dependent regulated cell death has been found to be intricately linked to ...
Aliki Papadimitriou‐Tsantarliotou, Chrysostomos Avgeros, Maria Konstantinidou, Ioannis S. Vizirianakis   +3 more
wiley   +1 more source

Repeated reunions and splits feature the highly dynamic evolution of 5S and 35S ribosomal RNA genes (rDNA) in the Asteraceae family

BMC Plant Biology, 2010
Background In flowering plants and animals the most common ribosomal RNA genes (rDNA) organisation is that in which 35S (encoding 18S-5.8S-26S rRNA) and 5S genes are physically separated occupying different chromosomal loci.
Garcia Sònia, Panero José L, Siroky Jiri, Kovarik Ales   +3 more
doaj   +1 more source

Temporal Changes in Tick‐Borne Pathogen Prevalence in Questing Ixodes ricinus Across Different Habitats in the North‐Eastern Italian Alps

MicrobiologyOpen, Volume 13, Issue 6, December 2024.
This study examines the prevalence of tick‐borne pathogens in Ixodes ricinus ticks in the north‐eastern Italian Alps. It found an average infection rate of 27.1%, with 11 zoonotic pathogens identified, showing varying infection rates across different years and habitats.
Fausta Rosso, Giulia Ferrari, Tobias Weil, Valentina Tagliapietra, Giovanni Marini, Francesca Dagostin, Daniele Arnoldi, Matteo Girardi, Annapaola Rizzoli   +8 more
wiley   +1 more source