Results 21 to 30 of about 1,556,083 (237)

Crosstalk between gut microbiota and tumor: tumors could cause gut dysbiosis and metabolic imbalance

Molecular Oncology, EarlyView.
In this research, we analyzed the relationship between gut microbiota and tumor. We discovered that both subcutaneous and metastatic tumors would alter the composition and metabolic function of gut microbiota. Meanwhile, fecal microbiota transplantation also indicated the anti‐tumor role of the gut microbiota, revealing the crosstalk between tumor and ...
Siyuan Zhang, Haimei Wen, Ying Chen, Jingya Ning, Di Hu, Yujiao Dong, Chenyu Yao, Bo Yuan, Shuanying Yang   +8 more
wiley   +1 more source

Obesity alters the fitness of peritumoral adipose tissue, exacerbating tumor invasiveness in renal cancer through the induction of ADAM12 and CYP1B1

Molecular Oncology, EarlyView.
Tumor microenvironment drives cancer formation and progression. We analyzed the role of human cancer‐associated adipocytes from patients with renal cell carcinoma (RCC) stratified as lean, overweight, or obese. RNA‐seq demonstrated that, among the most altered genes involved in the tumor–stroma crosstalk, are ADAM12 and CYP1B1, which were proven to be ...
Sepehr Torabinejad, Caterina Miro, Annarita Nappi, Francesco Del Giudice, Annunziata Gaetana Cicatiello, Serena Sagliocchi, Lucia Acampora, Federica Restolfer, Melania Murolo, Emery Di Cicco, Federico Capone, Ciro Imbimbo, Monica Dentice, Felice Crocetto   +13 more
wiley   +1 more source

Analisis Kebutuhan Debit Air Di Gedung C RSUD Kota Bukittinggi [PDF]

, 2021
In the Bukittinggi City Hospital building which has 6 floors, there is a water pump and a reservoir used to supply clean water for daily needs. Based on the reality in the field where there is no secondary data to determine the type of pump and reservoir.
Muharni, Riza, Nalahuddin, Muchlisi, Rizki, Mela Melarizki   +2 more
core   +2 more sources

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Groundwater and the Sustainable Development Goals (SDGs) [PDF]

, 2018
Groundwater is an important part of the water cycle, but this don’t reflects at all in the indicators for the Sustainable Development Goals (SDGs) of the United Nations (UN).
Chambel, António
core  

Invaders in hot water: a simple decontamination method to prevent the accidental spread of aquatic invasive non-native species. [PDF]

, 2015
Watersports equipment can act as a vector for the introduction and spread of invasive non native species (INNS) in freshwater environments. To support advice given to recreational water users under the UK Government’s Check Clean Dry biosecurity campaign
A Ricciardi, AD Stasko, Alison M. Dunn, B Gallardo, B Oidtmann, C Jerde, CR O’Neill, CS Kolar, D Dudgeon, DH Willits, DK Branstrator, DL Strayer, DM Holdich, E Briski, EJ Peeler, HR Ludwig, J Beyer, JV Kilian, K Bacela-Spychalska, KK Gates, KW Feldman, LAJ Buchan, LE Johnson, LG Anderson, Lucy G. Anderson, M Poznanska, MJ Vander Zanden, ML Bothwell, ML Johnson, MPJ Oreska, N Fielding, P Caplat, Paul D. Stebbing, Paula J. Rosewarne, PV Perepelizin, R Development Core Team, R Mack, S Comeau, TE Brooking, TV Dan   +39 more
core   +3 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Significance of clean water for sustainable good health in Nigeria [PDF]

, 2021
The significance of the impact of water-related diseases on human health has been recognized as a major threat to sustainable human development in some international forums.
Adekunle, Adebola A., Adeosun, Olayemi J., Adewumi, Babatunde E., Badejo, Adedayo A., Familusi, Ayokunle O., Mujedu, Kasali A., Ogundare, Damilola A., Olusami, Joel O.   +7 more
core   +4 more sources

Synthesis and application of hypercrosslinked polymers with weak cation-exchange character for the selective extraction of basic pharmaceuticals from complex environmental water samples [PDF]

, 2010
The synthesis of high specific surface area sorbents (HXLPP-WCX) in the form of hypercrosslinked polymer microspheres with narrow particle size distributions, average particle diameters around 6 µm, and weak cation exchange (WCX) character, is described.
Borrull, F., Bratkowska, D., Cormack, P.A.G., Fontanals, N., Marcé, R.M., Sherrington, D.C.   +5 more
core   +1 more source