Results 51 to 60 of about 3,588,383 (249)

Mitochondrial Dysfunction Unravels the Potential Molecular Link Between Night Shift Work‐Related Circadian Disruption and Elevated Blood Pressure in Human and Mouse Models

Advanced Science, EarlyView.
This diagram illustrates that night shift work disrupts circadian clock genes (like CLOCK, BMAL1) in both humans and mice. This disruption leads to mitochondrial dysfunction (imbalanced fusion/fission proteins) and increased oxidative stress, which is identified as the primary mechanism ultimately causing elevated blood pressure.
Zhaoqiang Jiang, Yifan Dou, Yingnan Lei, Shuang Liu, Jialin Zhou, Jiaping Li, Huadong Xu, Lingfang Feng, Yongxin Li, Chuyan Zhang, Tao Li, Jianfei Wang, Xing Zhang, Xinran Wang, Luyao Liu, Jingjing Zhang, Jianlin Lou   +16 more
wiley   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Pathogenicity and peramivir efficacy in immunocompromised murine models of influenza B virus infection

Scientific Reports, 2017
Influenza B viruses are important human pathogens that remain inadequately studied, largely because available animal models are poorly defined. Here, we developed an immunocompromised murine models for influenza B virus infection, which we subsequently ...
Philippe Noriel Q. Pascua, Heba H. Mostafa, Bindumadhav M. Marathe, Peter Vogel, Charles J. Russell, Richard J. Webby, Elena A. Govorkova   +6 more
doaj   +1 more source

DINÂMICA ESPAÇO-TEMPORAL NA DISSEMINAÇÃO DA COVID19 EM NITERÓI (RJ): UMA CONTRIBUIÇÃO GEOGRÁFICA NA FASE INICIAL DA PANDEMIA

Revista Tamoios, 2020
A Organização Mundial da Saúde (OMS) declarou em janeiro de 2020 que o surto da nova cepa de coronavírus - classificada como SARS-CoV-2 cuja doença denominada como COVID-19 - constitui uma Emergência de Saúde Pública de Importância Internacional.
Thiago dos Santos Leal, Otavio Miguez da Rocha Leão, Rafael Silva de Barros, Pedro Octávio Bittencourt Rezende   +3 more
doaj   +1 more source

Jorge Eliecer Gaitán, 60 Años

, 2008
Hoja de Mano que describe la exposición "Jorge Eliecer Gaitán, 60 Años". Contiene Biografía de este importante líder político e imágenes que acompañan la cronología de los sucesos del 9 de abril, día del Homicidio. Esta muestra hace parte del proyecto
Guio, Jose, Castell, Edmon
core  

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

Produtividade e exportação de nutrientes em beterraba cultivada com cobertura morta e adubação orgânica Yield and nutrient export of sugar beet under mulching and organic fertilization

Revista Brasileira de Engenharia Agrícola e Ambiental, 2011
Objetivou-se, com este trabalho, avaliar o efeito da cobertura do solo e doses de lodo de lagoa de decantação de água residuária de suinocultura na produtividade e na exportação de nutrientes pela beterraba, cultivar Early Wonder.
Maria A. N. Sediyama, Marlei R. Santos, Sanzio M. Vidigal, Luís T. Salgado   +3 more
doaj   +1 more source

Louisiana Cooperative Study -- 1957-60 -- Studies, OPV -- letter, 1960-08-12

, 1960
Letter from Sabin, Albert B. to Clemmer, Dorothy L.
Sabin, Albert B. (Albert Bruce), 1906-1993
core  

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source