Results 21 to 30 of about 1,255,458 (228)
Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2021 Interview with Michael Silverstone, cofounder of the company 600 Highwaymen with Abigail Browde. The interview was conducted by emails from May, 7th to August, 17th.
Emeline Jouve
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Infección experimental por herpesvirus bovino 1 en conejas gestantes
Analecta Veterinaria, 2011 La infección natural por Herpesvirus bovino 1 (BoHV-1) se manifiesta por conjuntivitis, signos respiratorios (rinotraqueitis), lesiones genitales (vulvovaginitis pustular infecciosa o balanopostitis) y abortos.
Alejandro Rafael::http://voc.sedici.unlp.edu.ar/node/66463::600 Valera +6 more
doaj +2 more sources
Analecta Veterinaria, 2011 En el presente estudio se analizó la prevalencia de anticuerpos contra el virus de la encefalomielitis de Theiler en colonias de ratones de Argentina.
Juan Martín::http://voc.sedici.unlp.edu.ar/node/65776::600 Laborde +8 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Analecta Veterinaria, 2011 Se realiza una revisión bibliográfica sobre cuadros clínicos obstructivos de vías aéreas inferiores por cuerpos extraños en caninos. Se presenta un informe de una serie de casos con resolución endoscópica.
Andrea::http://voc.sedici.unlp.edu.ar/node/66479::600 Giordano +2 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Evaluación de sistemas de alojamiento para ratones inmunodeficientes bajo experiencia
Analecta Veterinaria, 2011 Las investigaciones que utilizan ratones inmunodeficientes requieren el uso de una infraestructura adecuada y estandarizada, que debe garantizar el mantenimiento correcto de estas cepas y asegurar la obtención de resultados confiables.
Martín::http://voc.sedici.unlp.edu.ar/node/65782::600 Carriquiriborde +4 more
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FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source