Results 31 to 40 of about 5,574,252 (286)

The ethics of access: Towards an equal slice of the pie [PDF]

, 1991
Ethics is a system of moral principles and of values relating to the Tightness and wrongness of certain actions. When two diametrically opposed obligations conflict with one another, an ethical dilemma occurs.
Morrison, Samuel F.
core  

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Service scheduling in garden maintenance [PDF]

, 2012
Neoturf is a Portuguese company working in the area of project, building and garden’s maintenance. Neoturf would like to have a procedure for scheduling and routing efficiently the clients from garden maintenance services.
Cruz, M, Moura, A, Orestes Cerdeira, J
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Precise dispersive data analysis of the f0(600) pole [PDF]

, 2008
We review how the use of recent precise data on kaon decays together with forward dispersion relations (FDR) and Roy's equations allow us to determine the sigma resonance pole position very precisely, by using only experimental input.
J. R. PELAEZ, R. GARCÍA-MARTÍN, R. KAMIŃSKI, Yao W. M., Yndurain F. J., Zhou Z. Y.   +5 more
core   +3 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Meet 600 HIGHWAYMEN

Miranda: Revue Pluridisciplinaire du Monde Anglophone, 2021
Interview with Michael Silverstone, cofounder of the company 600 Highwaymen with Abigail Browde. The interview was conducted by emails from May, 7th to August, 17th.
Emeline Jouve
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Infección experimental por herpesvirus bovino 1 en conejas gestantes

Analecta Veterinaria, 2011
La infección natural por Herpesvirus bovino 1 (BoHV-1) se manifiesta por conjuntivitis, signos respiratorios (rinotraqueitis), lesiones genitales (vulvovaginitis pustular infecciosa o balanopostitis) y abortos.
Alejandro Rafael::http://voc.sedici.unlp.edu.ar/node/66463::600 Valera, Marcelo Ricardo Ítalo::http://voc.sedici.unlp.edu.ar/node/50068::600 Pecoraro, Nadia Analía::http://voc.sedici.unlp.edu.ar/node/48554::600 Fuentealba, Adriana Raquel::http://voc.sedici.unlp.edu.ar/node/65768::600 Massone, María Alejandra::http://voc.sedici.unlp.edu.ar/node/66494::600 Quiroga, Santiago Gerardo::http://voc.sedici.unlp.edu.ar/node/66443::600 Corva, Cecilia Mónica::http://voc.sedici.unlp.edu.ar/node/66429::600 Galosi   +6 more
doaj   +2 more sources