Results 31 to 40 of about 1,613,975 (290)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Infección experimental por herpesvirus bovino 1 en conejas gestantes

Analecta Veterinaria, 2011
La infección natural por Herpesvirus bovino 1 (BoHV-1) se manifiesta por conjuntivitis, signos respiratorios (rinotraqueitis), lesiones genitales (vulvovaginitis pustular infecciosa o balanopostitis) y abortos.
Alejandro Rafael::http://voc.sedici.unlp.edu.ar/node/66463::600 Valera, Marcelo Ricardo Ítalo::http://voc.sedici.unlp.edu.ar/node/50068::600 Pecoraro, Nadia Analía::http://voc.sedici.unlp.edu.ar/node/48554::600 Fuentealba, Adriana Raquel::http://voc.sedici.unlp.edu.ar/node/65768::600 Massone, María Alejandra::http://voc.sedici.unlp.edu.ar/node/66494::600 Quiroga, Santiago Gerardo::http://voc.sedici.unlp.edu.ar/node/66443::600 Corva, Cecilia Mónica::http://voc.sedici.unlp.edu.ar/node/66429::600 Galosi   +6 more
doaj   +2 more sources

Prevalencia de anticuerpos contra el virus de la encefalomielitis murina de Theiler en colonias de ratones de Argentina

Analecta Veterinaria, 2011
En el presente estudio se analizó la prevalencia de anticuerpos contra el virus de la encefalomielitis de Theiler en colonias de ratones de Argentina.
Juan Martín::http://voc.sedici.unlp.edu.ar/node/65776::600 Laborde, María del Pilar::http://voc.sedici.unlp.edu.ar/node/65777::600 Cagliada, Martín::http://voc.sedici.unlp.edu.ar/node/65782::600 Carriquiriborde, Cecilia::http://voc.sedici.unlp.edu.ar/node/65778::600 Carbone, Miguel Ángel::http://voc.sedici.unlp.edu.ar/node/65779::600 Ayala, Silvana::http://voc.sedici.unlp.edu.ar/node/65780::600 Milocco, Estela::http://voc.sedici.unlp.edu.ar/node/66464::600 Bonzo, Viviana::http://voc.sedici.unlp.edu.ar/node/66431::600 Cid de La Paz, Cecilia Mónica::http://voc.sedici.unlp.edu.ar/node/66429::600 Galosi   +8 more
doaj  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Obstrucción de vías aéreas inferiores por cuerpo extraño en perros: diagnóstico y tratamiento endoscópico

Analecta Veterinaria, 2011
Se realiza una revisión bibliográfica sobre cuadros clínicos obstructivos de vías aéreas inferiores por cuerpos extraños en caninos. Se presenta un informe de una serie de casos con resolución endoscópica.
Andrea::http://voc.sedici.unlp.edu.ar/node/66479::600 Giordano, Hugo Alfredo::http://voc.sedici.unlp.edu.ar/node/66499::600 Baschar, Adriana Noemí::http://voc.sedici.unlp.edu.ar/node/50018::600 Aprea   +2 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Análisis comparado de las reglas y usos uniformes 600 & 500 [PDF]

, 2013
1. APLICACIÓN DE LAS UCP 600 1.1. UCP 600: Artículo 1.1.2. UCP 500: Artículo 1.1.3. Comentarios:- Fuerza Vinculante - Jurisdicción - Exclusión o Modificación - Standby2. DEFINICIONES 2.1. UCP 600: Artículo 2.2.2.
Ustariz, Luis Humberto
core  

Evaluación de sistemas de alojamiento para ratones inmunodeficientes bajo experiencia

Analecta Veterinaria, 2011
Las investigaciones que utilizan ratones inmunodeficientes requieren el uso de una infraestructura adecuada y estandarizada, que debe garantizar el mantenimiento correcto de estas cepas y asegurar la obtención de resultados confiables.
Martín::http://voc.sedici.unlp.edu.ar/node/65782::600 Carriquiriborde, Cecilia::http://voc.sedici.unlp.edu.ar/node/65778::600 Carbone, María del Pilar::http://voc.sedici.unlp.edu.ar/node/65777::600 Cagliada, Juan Martín::http://voc.sedici.unlp.edu.ar/node/65776::600 Laborde, Fabricio Alejandro::http://voc.sedici.unlp.edu.ar/node/66496::600 Maschi   +4 more
doaj  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source