Results 1 to 10 of about 1,289,652 (188)

Subacute effects of the chlorinated flame retardant dechlorane 602 on intestinal microenvironment in mice

Environment International, 2022
Background: Chlorinated flame retardant Dechlorane 602 (Dec 602) has been detected in daily food, indicating that it may pose a risk to intestinal health. The intestinal microenvironment plays an important role in intestinal health. Intestinal microbiota
Yunping Li, Heidi Qunhui Xie, Yin Liu, Li Xu, Liping Zheng, Shuyuan Yu, Guomin Chen, Jiajia Ji, Shuai Jiang, Tai L. Guo, Bin Zhao   +10 more
doaj   +1 more source

Subacute exposure to dechlorane 602 dysregulates gene expression and immunity in the gut of mice

Ecotoxicology and Environmental Safety, 2023
Dechlorane 602 (Dec 602) has biomagnification potential. Our previous studies suggested that exposure to Dec 602 for 7 days induced colonic inflammation even after 7 days of recovery.
Yunping Li, Heidi Qunhui Xie, Tai L. Guo, Yin Liu, Wanglong Zhang, Hui Ma, Dan Ma, Li Xu, Shuyuan Yu, Guomin Chen, Jiajia Ji, Shuai Jiang, Bin Zhao   +12 more
doaj   +1 more source

Effects of GHRH Deficiency and GHRH Antagonism on Emotional Disorders in Mice

Cells, 2023
Growth hormone (GH)-releasing hormone (GHRH) has been suggested to play a crucial role in brain function. We aimed to further investigate the effects of a novel GHRH antagonist of the Miami (MIA) series, MIA-602, on emotional disorders and explore the ...
Lucia Recinella, Maria Loreta Libero, Serena Veschi, Anna Piro, Guya Diletta Marconi, Francesca Diomede, Annalisa Chiavaroli, Giustino Orlando, Claudio Ferrante, Rosalba Florio, Alessia Lamolinara, Renzhi Cai, Wei Sha, Andrew V. Schally, Roberto Salvatori, Luigi Brunetti, Sheila Leone   +16 more
doaj   +1 more source

El golpe de Estado de Focas (602)

Medievalista, 2022
Starting from a reassessment of the available sources, a review of one of the key moments in the historical development of the Eastern Roman Empire is proposed, the coup d’état that brought Phocas to power in 602.
Carlos Martínez Carrasco
doaj   +1 more source

Gap in Willingness and Access to Video Visit Use Among Older High-risk Veterans: Cross-sectional Study

Journal of Medical Internet Research, 2022
BackgroundThe recent shift to video care has exacerbated disparities in health care access, especially among high-need, high-risk (HNHR) adults.
Stuti Dang, Kiranmayee Muralidhar, Shirley Li, Fei Tang, Michael Mintzer, Jorge Ruiz, Willy Marcos Valencia   +6 more
doaj   +1 more source

Growth hormone-releasing hormone antagonist MIA-602 inhibits inflammation induced by SARS-CoV-2 spike protein and bacterial lipopolysaccharide synergism in macrophages and human peripheral blood mononuclear cells

Frontiers in Immunology, 2023
COVID-19 is characterized by an excessive inflammatory response and macrophage hyperactivation, leading, in severe cases, to alveolar epithelial injury and acute respiratory distress syndrome.
Giuseppina Granato, Giuseppina Granato, Iacopo Gesmundo, Iacopo Gesmundo, Francesca Pedrolli, Francesca Pedrolli, Ramesh Kasarla, Ramesh Kasarla, Laura Begani, Laura Begani, Dana Banfi, Dana Banfi, Stefania Bruno, Stefania Bruno, Tatiana Lopatina, Maria Felice Brizzi, Renzhi Cai, Renzhi Cai, Wei Sha, Ezio Ghigo, Ezio Ghigo, Andrew V. Schally, Andrew V. Schally, Andrew V. Schally, Andrew V. Schally, Riccarda Granata, Riccarda Granata   +26 more
doaj   +1 more source

Multidrug resistant 2009 A/H1N1 influenza clinical isolate with a neuraminidase I223R mutation retains its virulence and transmissibility in ferrets. [PDF]

PLoS Pathogens, 2011
Only two classes of antiviral drugs, neuraminidase inhibitors and adamantanes, are approved for prophylaxis and therapy against influenza virus infections.
Erhard van der Vries, Edwin J Veldhuis Kroeze, Koert J Stittelaar, Martin Linster, Anne Van der Linden, Eefje J A Schrauwen, Lonneke M Leijten, Geert van Amerongen, Martin Schutten, Thijs Kuiken, Albert D M E Osterhaus, Ron A M Fouchier, Charles A B Boucher, Sander Herfst   +13 more
doaj   +1 more source

GZ17-6.02 and Doxorubicin Interact to Kill Sarcoma Cells via Autophagy and Death Receptor Signaling

Frontiers in Oncology, 2020
GZ17-6.02 (602) is presently under phase I clinical evaluation (NCT03775525). We defined the mechanisms by which it interacted with a standard of care therapeutic doxorubicin to kill sarcoma cells.
Laurence Booth, Cameron West, Daniel Von Hoff, Paul Dent   +3 more
doaj   +1 more source

Anti-Inflammatory Effects of β-Cryptoxanthin on 5-Fluorouracil-Induced Cytokine Expression in Human Oral Mucosal Keratinocytes

Molecules, 2023
Oral mucositis is a typical adverse effect of chemotherapy, causing oral pain that significantly reduces the patient’s quality of life. β-cryptoxanthin (β-cry) is a carotenoid abundant in citrus fruits with antioxidant and anti-inflammatory effects ...
Hironaka Yamanobe, Kenta Yamamoto, Saki Kishimoto, Kei Nakai, Fumishige Oseko, Toshiro Yamamoto, Osam Mazda, Narisato Kanamura   +7 more
doaj   +1 more source

Disciplining, chastisement and physical child abuse: perceptions and attitudes of the British Pakistani community [PDF]

, 2004
There are a number of cross-cultural differences in people's perspectives of what constitutes physical abuse of children. The focus of the present study was to explore the British Pakistani community's perception about physical child abuse and to ...
Cowburn, M., Irfan, S.
core   +1 more source