miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis [PDF]
Biology DirectBackground MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs).
Jun Zou +5 more
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Mixed active metabolites of the SNP-6 series of novel compounds mitigate metabolic dysfunction-associated steatohepatitis and fibrosis: promising results from pre-clinical and clinical trials [PDF]
Journal of Translational MedicineBackground Metabolic dysfunction-associated steatohepatitis (MASH) is a growing global health concern with no effective pharmacological treatments. SNP-630, a newly developed synthetic molecule with multiple mechanisms of action, and a mixture of two of ...
Hsin-Tien Ho +13 more
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The importance of miRNA-630 in human diseases with an especial focus on cancers
Cancer Cell International, 2022 miR-630 is encoded by MIR630 gene (NC_000015.10) on 15q24.1. This miRNA is mostly associated with cytokine signaling in immune system. Several neoplastic as well as non-neoplastic conditions have been linked with dysregulation of miR-630.
Sepideh Kadkhoda, Soudeh Ghafouri-Fard
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Effect of Photobiomodulation With Different Wavelengths on Radiodermatitis Treatment
Plastic and Reconstructive Surgery, Global Open, 2023 Background:. Approximately 80% of patients submitted to radiotherapy develop radiodermatitis. Photobiomodulation based on light-emitted diode (LED) is one of the therapeutic strategies for treating inflammation. This study aimed to investigate the effect
Cristina Pires Camargo, MD, PhD +10 more
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miR-378a-5p and miR-630 induce lens epithelial cell apoptosis in cataract via suppression of E2F3 [PDF]
Brazilian Journal of Medical and Biological Research, 2020 Cataract, an eye disease that threatens the health of millions of people, brings about severe economic burden for patients and society. MicroRNA (miR)-378a-5p and miR-630 were recognized as essential regulators in multiple cancers.
Weiwei Gao, Xiaoqing Zhou, Ruihua Lin
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Novel Epigenetic CREB-miR-630 Signaling Axis Regulates Radiosensitivity in Colorectal Cancer. [PDF]
PLoS ONE, 2015 miR-630 has been reported to be a modulator of several cancers, but the mechanism by which is it influences radioresistance remains unknown. We aimed to identify the molecular function of miR-630 and its regulatory mechanism in colorectal cancer (CRC ...
Yan Zhang +6 more
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Journal of Immunology Research, 2022 Purpose. Hypoxia has crucial functions in the development and metastasis of cervical cancer by inducing the expression of numerous genes, including microRNA genes.
Qiaohui Gao +6 more
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Cells, 2023 Head and neck cancer (HNC) ranks among the top ten prevalent cancers worldwide. Radiotherapy stands as a pivotal treatment component for HNC; however, radioresistance in cancerous cells often leads to local recurrence, becoming a substantial factor in ...
Guo-Rung You +7 more
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Study on the effect of nine nucleic acid extraction lysing reagents on PCR amplification efficiency
Zhongguo shipin weisheng zazhi, 2023 ObjectiveTo explore the maximum allowable concentration of six chemical reagents and three enzyme lysates in a polymerase chain reaction （PCR） amplification system and the differences of IGEPAL CA-630 cleaving different species.MethodsPrepare different ...
LIU Na +3 more
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Increased microRNA-630 expression in gastric cancer is associated with poor overall survival. [PDF]
PLoS ONE, 2014 MicroRNAs are noncoding RNAs that regulate multiple cellular processes during cancer progression. Among various microRNAs, MiR-630 has recently been identified to be implicated in many critical processes in human malignancies. We aimed to investigate the
Dake Chu +7 more
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