The authors have discovered that intracellular interleukin 1 receptor 2 (IL1R2) negatively regulates pyroptosis and inflammation by inhibiting glycolysis in sepsis. Soluble IL1R2 is released from macrophages undergoing pyroptosis. IL1R2 acts as a novel negative regulator of glycolysis by interacting with enolase 1 (ENO1), thereby inhibiting gasdermin D
Chuyi Tan+13 more
wiley +1 more source
Comparative study of AA6061 and AA6063 aluminum alloy coating on mild steel using friction surfacing. [PDF]
Karar GC+3 more
europepmc +1 more source
Quasiperiodic southward moving waves in 630‐nm airglow images in the equatorial thermosphere [PDF]
K. Shiokawa, Yuichi Otsuka, T. Ogawa
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Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang+6 more
wiley +1 more source
Toluidine Blue for the Determination of Binding of Anionic Polysaccharides to Lipid Raft Domains by Absorption Spectroscopy. [PDF]
Gębczyńska S+6 more
europepmc +1 more source
630. A Phase 2 Randomized Study of GM-CSF Gene-Modified Autologous Tumor Cell Immunotherapy (CG8123) with and without Low- Dose Cyclophosphamide in Advanced Stage Non- Small Cell Lung Cancer (NSCLC) [PDF]
John Nemunaitis+10 more
openalex +1 more source
HOP, an innovative ICT‐based fluorescent probe, visualizes H2O2 in stressed neurons while locally releasing serotonin (5‐HT) for real‐time protein interaction mapping. Its unique tandem sensing and labeling strategy reveals 5‐HT's role under oxidative stress, offering a powerful tool for neurophysiological research and therapeutic discovery.
Yani Liu+9 more
wiley +1 more source
N‑Terminal Conjugation of a Near-Infrared Photosensitizer to an Antibody for Cancer Diagnosis and Treatment. [PDF]
Qiu Z+4 more
europepmc +1 more source
Multidimensional HBT correlations in pp̄ collisions at s = 630 GeV [PDF]
H. C. Eggers
openalex +1 more source