Results 11 to 20 of about 149 (148)

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

open access: yesMolecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita   +1 more
wiley   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

A Novel Approach on Rapid Alloy Development of Tool Steels for Laser Powder Bed Fusion by In Situ Alloying

open access: yesAdvanced Engineering Materials, EarlyView.
A novel approach for alloy development in laser powder bed fusion is introduced. Instead of producing massive samples of one composition at a time, prepressed powder bed samples produced from powder mixtures are processed. Guidelines for the selection of precursor powders are developed.
Felix Großwendt   +6 more
wiley   +1 more source

Geometry‐Based Scan Curve Analysis: Rapid Method for the Evaluation of Scan Strategies in Powder Bed Fusion

open access: yesAdvanced Engineering Materials, EarlyView.
This study presents rapid evaluation methods for scan strategies in powder bed fusion (PBF) of polymers with a NIR laser as an example for its application. It uses line buffer‐based calculations and point density fields to predict the performance of four different scan strategies. The methods show promising results in laser‐based PBF of polymer samples,
Simon Leupold   +9 more
wiley   +1 more source

Joule‐Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures

open access: yesAdvanced Functional Materials, EarlyView.
Joule‐assisted nanotherapeutic urethral stent harnesses a smart, biodegradable magnesium stent to orchestrate spatiotemporal theragenerative therapy for urethral strictures. Magnetically induced Joule heating enables on‐demand drug release and bacterial ablation, while simultaneously guiding urothelial regeneration.
Yuhyun Na   +15 more
wiley   +1 more source

3D Printed Ultra‐Fast Plastic Scintillators Based on Perovskite‐Photocurable Polymer Composite

open access: yesAdvanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
The demand for radiation detection is increasing in a number of fields, including high‐energy physics, medical imaging, and homeland security. This study serves to demonstrate the potential for the fabrication of fast perovskite‐based scintillators with complex shapes via stereolithographic additive manufacturing, representing a new path toward the ...
Antonella Giuri   +16 more
wiley   +1 more source

Selective Reduction Laser Sintering: A New Strategy for NO2 Gas Detection Based on In2O3 Nanoparticles

open access: yesAdvanced Functional Materials, EarlyView.
This research utilizes selective reduction laser sintering (SRLS) to engineer In2O3 NPs for flexible NO2 sensors. The introduction of oxygen vacancy defects enhances sensor performance, offering excellent responsiveness, rapid response/recovery, superior selectivity, low detection limit, and long‐term stability.
Shaogang Wang   +8 more
wiley   +1 more source

Print‐and‐Plate Architected Electrodes for Electrochemical Transformations Under Flow

open access: yesAdvanced Functional Materials, EarlyView.
Typical flow cell electrodes are composed of stochastic porous carbon, limiting understanding of electrode structure‐performance relationships. This work describes an approach, termed “print‐and‐plate,” to prepare porous electrodes by direct ink writing followed by conformal metal coating.
Dylan M. Barber   +12 more
wiley   +1 more source

Off‐Stoichiometry Engineering of the Electrical and Optical Properties of SrNbO3 Using Oxide Molecular Beam Epitaxy

open access: yesAdvanced Functional Materials, EarlyView.
The plasma edge of transparent conducting oxide SrNbO3 shifts from ∼2 eV in the visible range to 1.37 eV in the near‐infrared region by off‐stoichiometry using the vacancy sites as quasi‐substitutional virtual elements. This work advances the stoichiometry engineering of perovskite oxides using oxide molecular beam epitaxy, allowing synthesis beyond ...
Jasnamol Palakkal   +11 more
wiley   +1 more source

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