Results 31 to 40 of about 194,451 (149)

Mixed active metabolites of the SNP-6 series of novel compounds mitigate metabolic dysfunction-associated steatohepatitis and fibrosis: promising results from pre-clinical and clinical trials

Journal of Translational Medicine
Background Metabolic dysfunction-associated steatohepatitis (MASH) is a growing global health concern with no effective pharmacological treatments. SNP-630, a newly developed synthetic molecule with multiple mechanisms of action, and a mixture of two of ...
Hsin-Tien Ho, Yu-Lueng Shih, Tien-Yu Huang, Wen-Hui Fang, Chang-Hsien Liu, Jung-Chun Lin, Chih-Weim Hsiang, Kai-Min Chu, Cheng-Huei Hsiong, Guan-Ju Chen, Yung-En Wu, Jia-Yu Hao, Chih-Wen Liang, Oliver Yoa-Pu Hu   +13 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

High performance top gate a-IGZO TFT utilizing siloxane hybrid material as a gate insulator

AIP Advances, 2018
We demonstrated gate insulators (GI) fabricated by solution process with the aim of replacing traditional vacuum processed GI. We selected solution siloxane-based material due to its extremely high thermal resistance, excellent transparency, flexibility,
Chaiyanan Kulchaisit, Juan Paolo Soria Bermundo, Mami N. Fujii, Yasuaki Ishikawa, Yukiharu Uraoka   +4 more
doaj   +1 more source

Potential tactics with vitamin D and certain phytochemicals for enhancing the effectiveness of immune-checkpoint blockade therapies

Exploration of Targeted Anti-tumor Therapy, 2023
Immunotherapy strategies targeting immune checkpoint molecules such as programmed cell death-1 (PD-1) and cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) are revolutionizing oncology.
Ai Tsuji, Sayuri Yoshikawa, Sae Morikawa, Yuka Ikeda, Kurumi Taniguchi, Haruka Sawamura, Tomoko Asai, Satoru Matsuda   +7 more
doaj   +1 more source

Policy Challenges Related to Biofuel Development in Tanzania Politische Herausforderungen in Bezug auf Biokraftstoffe in Tansania

Africa Spectrum, 2010
Biofuels have recently emerged as a major issue in energy policy, agricultural development and natural resource management. The growing demand for biofuels is being driven by high oil prices, energy security concerns and global climate change.
Hussein Sosovele
doaj  

Gelidiales Are Not Just Agar—Revealing the Antimicrobial Potential of Gelidium corneum for Skin Disorders

Antibiotics, 2022
In recent decades, seaweeds have proven to be an excellent source of bioactive molecules. Presently, the seaweed Gelidium corneum is harvested in a small area of the Portuguese coast exclusively for agar extraction.
Margarida Matias, Susete Pinteus, Alice Martins, Joana Silva, Celso Alves, Teresa Mouga, Helena Gaspar, Rui Pedrosa   +7 more
doaj   +1 more source

Impacts of perR on oxygen sensitivity, gene expression, and murine infection in Clostridioides difficile 630∆erm

Journal of Bacteriology
Clostridioides difficile infection (CDI), characterized by colitis and diarrhea, afflicts approximately half a million people in the USA every year, burdening both individuals and the healthcare system. C.
Anna L. Gregory, Hailey E. Bussan, Madeline A. Topf, Andrew J. Hryckowian   +3 more
doaj   +1 more source

miR-630 as a therapeutic target in pancreatic cancer stem cells: modulation of the PRKCI-Hedgehog signaling axis

Biology Direct
Background MicroRNAs (miRNAs) are critical regulators of cancer progression, prompting our investigation into the specific function of miR-630 in pancreatic cancer stem cells (PCSCs).
Jun Zou, Sha Yang, Chongwu He, Lei Deng, Bangran Xu, Shuai Chen   +5 more
doaj   +1 more source

Influence of carbon impurities and oxygen vacancies in Al2O3 film on Al2O3/GaN MOS capacitor characteristics

AIP Advances, 2018
Effects of carbon impurities and oxygen vacancies in Al2O3 film on the characteristics of Al2O3/GaN MOS capacitors were studied using the different atomic layer deposition (ALD) precursor and high-pressure water vapor annealing (HPWVA).
Mutsunori Uenuma, Kiyoshi Takahashi, Sho Sonehara, Yuta Tominaga, Yuta Fujimoto, Yasuaki Ishikawa, Yukiharu Uraoka   +6 more
doaj   +1 more source

Characterization of PVC/PEMA Based Polymer Blend Electrolytes

International Journal of Electrochemical Science, 2008
Polymer electrolyte membranes comprising of poly (ethyl methacrylate)/ poly (vinyl chloride), propylene carbonate (PC) as plasticizer and LiClO4 as salt were prepared by solvent casting technique.
S. Rajendran, M. Ramesh Prabhu, M. Usha Rani   +2 more
doaj   +1 more source