Results 31 to 40 of about 1,884,502 (336)

Changes in Neutrophil Count During Valganciclovir Therapy for Symptomatic Congenital Cytomegalovirus Infection

Biomedicines
Background/Objectives: Neutropenia is a common adverse effect of oral valganciclovir (VGCV) treatment in infants with congenital cytomegalovirus infection (CCMVI), with an estimated prevalence of 20%.
Aoi Kawamura, Shinya Abe, Keisuke Shirai, Yu Masuda, Yukihito Imagawa, Yuki Nakata, Takumi Kido, Mariko Ashina, Hisayuki Matsumoto, Kenji Tanimura, Yasumasa Kakei, Takumi Imai, Kandai Nozu, Kazumichi Fujioka   +13 more
doaj   +1 more source

A study on the inhibitory mechanism for cholesterol absorption by α-cyclodextrin administration

Beilstein Journal of Organic Chemistry, 2014
Background: Micelle formation of cholesterol with lecithin and bile salts is a key process for intestinal absorption of lipids. Some dietary fibers commonly used to reduce the lipid content in the body are thought to inhibit lipid absorption by binding ...
Takahiro Furune, Naoko Ikuta, Yoshiyuki Ishida, Hinako Okamoto, Daisuke Nakata, Keiji Terao, Norihiro Sakamoto   +6 more
doaj   +1 more source

Fluorescent-Antibody Targeting of Insulin-Like Growth Factor-1 Receptor Visualizes Metastatic Human Colon Cancer in Orthotopic Mouse Models. [PDF]

, 2016
Fluorescent-antibody targeting of metastatic cancer has been demonstrated by our laboratory to enable tumor visualization and effective fluorescence-guided surgery.
Bouvet, Michael, Hoffman, Robert M, Lee, Jin Young, Murakami, Takashi, Park, Jeong Youp, Zhang, Yong   +5 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparison of pathophysiology in subclinical hyperthyroidism with different etiologies

Endocrine Journal
Subclinical hyperthyroidism (SHyper) is defined as normal levels of free thyroxine (fT4) and free triiodothyronine (fT3) with suppressed levels of TSH.
Hanna Deguchi-Horiuchi, Mitsuru Ito, Sawako Takahashi, Kazuyoshi Kousaka, Mako Hisakado, Shuji Fukata, Takumi Kudo, Eijun Nishihara, Mitsushige Nishikawa, Akira Miyauchi, Takashi Akamizu   +10 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Active surveillance for adult low-risk papillary thyroid microcarcinoma—a review focused on the 30-year experience of Kuma Hospital—

Endocrine Journal
Active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective ...
Yasuhiro Ito, Akira Miyauchi, Makoto Fujishima, Masashi Yamamoto, Takahiro Sasaki   +4 more
doaj   +1 more source

Experimental Verification of the Number Relation at Room and Elevated Temperatures [PDF]

, 1983
The accuracy of the Neuber equation for predicting notch root stress-strain behavior at room temperature and at 650 C was experimentally investigated.
Lucas, L. J., Martin, J. F.
core   +1 more source

Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients [PDF]

, 2013
We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression.
Black, Callewaert, Chen, Claire Adams, Clare Orange, Fu, Gaughan, Gioeli, Gioeli, Gordon, Hsu, Jennifer Willder, Joanne Edwards, Kirkegaard, Lin, Lindsay Bennett, Mahajan, Mark Underwood, Mccall, Mccall, Mellinghoff, Pamela McCall, Ponguta, Rochette-Egly, Shigemura, Tahir Qayyum, Tam, Taneja, Traynor, Van Laar, Wen, Willder, Wong, Zhou, Zong   +34 more
core   +3 more sources

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source