Results 41 to 50 of about 579,654 (322)

Obstetric Intensive Care Admissions and Neonatal Outcomes: 15 Years of Experience from a Single Center

Medicina
Background and Objectives: Maternal severe morbidity and mortality are measures for assessing maternal healthcare, and admissions to the intensive care unit (ICU) can be used to study these metrics.
Filipa Ramalho Rocha, Tiago Neto Gonçalves, Maria Inês Xavier-Ferreira, Francisco Laranjeira, Gonçalo Meleiro Magalhães, Maria Inês Lopes, Marta Sousa, Daniela Pestana, Élia Fernandes, Ana Chung, Ana Berdeja, Gonçalo Cassiano Santos, Natália Marto, António Messias, Jorge Lima   +14 more
doaj   +1 more source

Quantification of Pregenomic RNA and Covalently Closed Circular DNA in Hepatitis B Virus-Related Hepatocellular Carcinoma

International Journal of Hepatology, 2013
Pregenomic RNA (pgRNA) is generated from covalently closed circular DNA (cccDNA) and plays important roles in viral genome amplification and replication. Hepatic pgRNA and cccDNA expression levels indicate viral persistence and replication activity. This
Fugui Bai, Yoshihiko Yano, Takumi Fukumoto, Atsushi Takebe, Motofumi Tanaka, Kaori Kuramitsu, Nungki Anggorowati, Hanggoro Tri Rinonce, Dewiyani Indah Widasari, Masaya Saito, Hirotaka Hirano, Takanobu Hayakumo, Yasushi Seo, Takeshi Azuma, Yonson Ku, Yoshitake Hayashi   +15 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Changes in Neutrophil Count During Valganciclovir Therapy for Symptomatic Congenital Cytomegalovirus Infection

Biomedicines
Background/Objectives: Neutropenia is a common adverse effect of oral valganciclovir (VGCV) treatment in infants with congenital cytomegalovirus infection (CCMVI), with an estimated prevalence of 20%.
Aoi Kawamura, Shinya Abe, Keisuke Shirai, Yu Masuda, Yukihito Imagawa, Yuki Nakata, Takumi Kido, Mariko Ashina, Hisayuki Matsumoto, Kenji Tanimura, Yasumasa Kakei, Takumi Imai, Kandai Nozu, Kazumichi Fujioka   +13 more
doaj   +1 more source

An Incarcerated Colon Inguinal Hernia That Perforated into the Scrotum and Exhibited an Air-Fluid Level

Case Reports in Medicine, 2015
There are few reports of a transverse colon inguinal hernia; furthermore, an inguinal hernia perforating the scrotum is rare. Here we report the case of a 79-year-old man who died after developing an incarcerated colon inguinal hernia that perforated the
Seisuke Ota, Toshio Noguchi, Tomoya Takao, Takumi Sakamoto, Yuichiro Kanie, Ken-ichi Omae, Shunji Fujie, Yoshiaki Kanaya, Akinori Kasahara, Tadashi Matsumra   +9 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Comparison of pathophysiology in subclinical hyperthyroidism with different etiologies

Endocrine Journal
Subclinical hyperthyroidism (SHyper) is defined as normal levels of free thyroxine (fT4) and free triiodothyronine (fT3) with suppressed levels of TSH.
Hanna Deguchi-Horiuchi, Mitsuru Ito, Sawako Takahashi, Kazuyoshi Kousaka, Mako Hisakado, Shuji Fukata, Takumi Kudo, Eijun Nishihara, Mitsushige Nishikawa, Akira Miyauchi, Takashi Akamizu   +10 more
doaj   +1 more source

A study on the inhibitory mechanism for cholesterol absorption by α-cyclodextrin administration

Beilstein Journal of Organic Chemistry, 2014
Background: Micelle formation of cholesterol with lecithin and bile salts is a key process for intestinal absorption of lipids. Some dietary fibers commonly used to reduce the lipid content in the body are thought to inhibit lipid absorption by binding ...
Takahiro Furune, Naoko Ikuta, Yoshiyuki Ishida, Hinako Okamoto, Daisuke Nakata, Keiji Terao, Norihiro Sakamoto   +6 more
doaj   +1 more source

Hesychius Σ 650-651 Schmidt

Emerita, 1984
No disponible.
Tiziano Dorandi
doaj   +1 more source

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source