Results 41 to 50 of about 89,320 (247)

Metformin and Cancer Hallmarks: Molecular Mechanisms in Thyroid, Prostate and Head and Neck Cancer Models

Biomolecules, 2022
Metformin is the most used drug for type 2 diabetes (T2DM). Its antitumor activity has been described by clinical studies showing reduced risk of cancer development in T2DM patients, as well as management of T2DM compared with those receiving other ...
Mirian Galliote Morale, Rodrigo Esaki Tamura, Ileana Gabriela Sanchez Rubio   +2 more
doaj   +1 more source

Ionic–Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy

Advanced Science, EarlyView.
Ionic–bionic interfaces for bioelectronics leverage ions as multifunctional mediators that combine mechanical compliance, ionic and electronic functionalities, and therapeutic effects. These systems offer real‐time biosignal transduction, effective wound dressing, responsive drug delivery, and seamless interaction between soft tissues and electronic ...
Yun Goo Ro, Yoojin Chang, Jeeyoon Kim, Seungjae Lee, Sangyun Na, Cheolhong Park, Hyunhyub Ko   +6 more
wiley   +1 more source

Variabilidad fenotipica y genotipica de poblaciones de Lotus tenuis que habitan suelos con distinto pH

Ecología Austral, 1998
Lotus tenuis es una leguminosa forrajera exótica que crece en forma espontánea en la Depresión del Río Salado (Prov. De Buenos Aires, Argentina) y presenta una gran amplitud ecológica en relación al pH del suelo.
Susana L. Stoffella, Gabriela Posse, Marta B. Collantes   +2 more
doaj  

Deciphering the Proteotoxic Stress Responses Triggered by the Perturbed Thylakoid Proteostasis in Arabidopsis

Plants, 2021
Here, we explored heat dependent thylakoid FtsH protease substrates and investigated proteotoxicity induced by thermal damage and processive protease dysfunction on the thylakoid membrane.
Kenji Nishimura, Reiko Nakagawa, Chisato Hachisuga, Yuri Nakajima Munekage   +3 more
doaj   +1 more source

The Influence of Surgeons' Gender on Surgical Outcomes in Laparoscopic Right Hemicolectomy: A Japanese Nationwide Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
This study analyzed 58 503 laparoscopic right hemicolectomies for colon cancer in Japan between 2018 and 2022, comparing outcomes between male and female surgeons. No significant differences were found in surgical mortality or severe complications. Tailored surgical training programs for female surgeons may further enhance surgical outcomes.
Akihisa Matsuda, Hideki Endo, Aya Yamagishi, Hiroyuki Yamamoto, Shuji Takiguchi, Koki Otsuka, Takeshi Yamada, Hiroshi Yoshida, Hideki Ueno, Yuko Kitagawa, Ken Shirabe   +10 more
wiley   +1 more source

Comparison Between Upfront Surgery and Preoperative Chemotherapy for CY1P0 Gastric Cancer: A Japanese Sub‐Analysis of CONVO‐GC‐1

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Radical gastrectomy, followed by adjuvant chemotherapy has been a common practice in Japan for peritoneal lavage cytology‐positive (CY1) but peritoneal dissemination‐negative (P0) stage IV gastric cancer. This study aimed to clarify the differences in treatment outcomes between upfront surgery and preoperative chemotherapy, followed
Kenichiro Furukawa, Itaru Yasufuku, Hironori Ishigami, Masahiro Yura, Takanobu Yamada, Shigeaki Baba, Takeshi Kubota, Erina Nagai, Seito Fujibayashi, Mitsumasa Yoshida, Takahiro Kinoshita, Nobuhisa Matsuhashi, Masanori Terashima   +12 more
wiley   +1 more source

Inverse Design of Alloys via Generative Algorithms: Optimization and Diffusion within Learned Latent Space

Advanced Intelligent Discovery, EarlyView.
This work presents a novel generative artificial intelligence (AI) framework for inverse alloy design through operations (optimization and diffusion) within learned compact latent space from variational autoencoder (VAE). The proposed work addresses challenges of limited data, nonuniqueness solutions, and high‐dimensional spaces.
Mohammad Abu‐Mualla, Ellis Crabtree, Fredrick Michael, Yayue Pan, Jida Huang   +4 more
wiley   +1 more source

Variabilidad poblacional de Lotus glaber en relación con la absorción de fósforo del suelo

Ecología Austral, 2000
Se estudió la variabilidad poblacional de L. glaber (ex L. tenuis) en suelos de la Depresión del Río Salado (Pcia. de Buenos Aires) a través de caracteres morfofisiológicos relacionados con la absorción de P. Se compararon dos poblaciones de L.
R. E. Mendoza, E. Pagani, M. C. Pomar
doaj  

Understanding the Housing and Support Experience of People With Complex Disability in Australia: A Qualitative Analysis of Submissions to the Disability Royal Commission

Australian Journal of Social Issues, EarlyView.
ABSTRACT In 2019, the Australian government established the Royal Commission into Violence, Abuse, Neglect and Exploitation of People with Disability (‘Disability Royal Commission’, DRC) to investigate widespread mistreatment of people with disability. Nearly 10,000 people with disability, their families and supporters engaged with the DRC.
Kate D'Cruz, Fiona Carey, Libby Witts, Jessie Spence, Peter Mulherin, Megan Topping, Di Winkler, Jacinta Douglas   +7 more
wiley   +1 more source

Divergent Asymmetric Total Synthesis of All Four Pestalotin Diastereomers from (R)-Glycidol

Molecules, 2020
All four chiral pestalotin diastereomers were synthesized in a straightforward and divergent manner from common (R)-glycidol. Catalytic asymmetric Mukaiyama aldol reactions of readily-available bis(TMSO)diene (Chan’s diene) with (S)-2 ...
Mizuki Moriyama, Kohei Nakata, Tetsuya Fujiwara, Yoo Tanabe   +3 more
doaj   +1 more source