Results 91 to 100 of about 23,617 (228)

Proteomic analysis of the zone of degeneration at the mitosis–meiosis transition stage in wild‐caught male catshark (Scyliorhinus canicula), correlated with an unusually high‐water temperature in the English Channel

Journal of Fish Biology, Volume 108, Issue 2, Page 676-693, February 2026.
Abstract In the context of current global change, variations in water temperature are one of the environmental conditions with serious consequences for marine life, including reproductive processes. In the small spotted catshark Scyliorhinus canicula, spermatogenesis occurs in spermatocysts composed of synchronously developing germ cells associated ...
Fabian Jeanne, Stanislas Pilet, Sean Heighton, Benoît Bernay, Pascal Sourdaine   +4 more
wiley   +1 more source

Maternal VDR variants rather than 25-hydroxyvitamin D concentration during early pregnancy are associated with type 1 diabetes in the offspring [PDF]

, 2016
This study was supported by the Finnish Academy (grant 127219), the European Foundation for the Study of Diabetes, the Novo Nordisk Foundation, the Diabetes Research Foundation, the EVO funding of the South Ostrobothnia Central Hospital from the ...
AG Uitterlinden, AW Norman, B Frederiksen, B-W Ogunkolade, BN Frederiksen, Christel Lamberg-Allardt, Christopher Mathews, D Saccone, E Hyppönen, E Ramos-Lopez, E Ramos-Lopez, EL Barry, Graham A. Hitman, Heljä-Marja Surcel, HK Brekke, HT Siljander, IM Sørensen, J Ahn, J Ahn, J Esparza-Gordillo, J Raab, Jaakko Tuomilehto, JD Cooper, JJ McGrath, JR Pilsner, L Marjamäki, LC Stene, LC Stene, Leena Kinnunen, M Shahbazi, M Simpson, Maija E. Miettinen, ME Miettinen, Melissa C. Smart, MF Holick, NJ Knaap van der, R Bailey, S Nejentsev, SJ James, SM Orton, The EURODIAB Substudy 2 Study Group, TJ Wang, Valma Harjutsalo, X Guillot, Y Benjamini   +44 more
core   +1 more source

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

Relationship between polymorphisms in vitamin D metabolism-related genes and the risk of rickets in Han Chinese children [PDF]

, 2013
BACKGROUND: Vitamin D deficiency rickets is common in China. Genetic factors may play an important role in the susceptibility to rickets. Our study aimed to identify the relationship between three vitamin D-related genes (group specific component [GC ...
Lihong Ren, Shufen Yang, Ye Liu, Yuling Zhang   +3 more
core   +1 more source

Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes. [PDF]

Journal of Clinical Investigation, 1995
We investigated the enzyme defect in late cholesterol biosynthesis in the Smith-Lemli-Opitz syndrome, a recessively inherited developmental disorder characterized by facial dysmorphism, mental retardation, and multiple organ congenital anomalies. Reduced plasma and tissue cholesterol with increased 7-dehydrocholesterol concentrations are biochemical ...
S, Shefer, G, Salen, A K, Batta, A, Honda, G S, Tint, M, Irons, E R, Elias, T C, Chen, M F, Holick   +8 more
openaire   +2 more sources

Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis

Lipids, Volume 61, Issue 1, Page 151-162, January 2026.
ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato   +4 more
wiley   +1 more source

Synovial fluid alpha‐2‐macroglobulin, gelsolin and lubricin distinguish between osteoarthritic and healthy equine joints

Equine Veterinary Journal, Volume 58, Issue 1, Page 49-59, January 2026.
Abstract Background Synovial fluid (SF) is an ideal sentinel fluid for osteoarthritis (OA) diagnosis and prognostication due to its critical homeostatic role, proximity to articular tissues and immune cell composition. Untargeted proteomics enable identification of soluble markers for diagnostic and therapeutic applications while minimising bias ...
Erica J. Secor, Sydney J. Womack, Machiel P. Ysebaert, Marshall J. Colville, Heidi L. Reesink   +4 more
wiley   +1 more source

Smith Lemli Opitz syndrome: a case report

Khyber Medical University Journal, 2015
INTRODUCTION; Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive genetic condition caused by deficiency of the enzyme 7-dehydrocholesterol-delta 7-reductase.
saima ali, Saffiullah Khalil, Liaqat Ali
doaj  

Biochemical and physiological improvement in a mouse model of Smith–Lemli–Opitz syndrome (SLOS) following gene transfer with AAV vectors

Molecular Genetics and Metabolism Reports, 2014
Smith–Lemli–Opitz syndrome (SLOS) is an inborn error of cholesterol synthesis resulting from a defect in 7-dehydrocholesterol reductase (DHCR7), the enzyme that produces cholesterol from its immediate precursor 7-dehydrocholesterol.
Lee Ying, Xavier Matabosch, Montserrat Serra, Berna Watson, Cedric Shackleton, Gordon Watson   +5 more
doaj   +1 more source

Intermediary metabolism [PDF]

, 2009
Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic intermediary metabolism, suggesting that the major metabolic pathways are probably present in this species.
Braeckman, Bart, Houthoofd, Koen, Vanfleteren, Jacques   +2 more
core   +2 more sources