Results 1 to 10 of about 8,314 (148)

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey [PDF]

Molecules, 2020
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP11A1
Adrian Fabisiak, Robert C Tuckey
exaly   +8 more sources

Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites [PDF]

Journal of Steroid Biochemistry and Molecular Biology, 2021
7-Dehydrocholesterol reductase (DHCR7) catalyses the final step of cholesterol biosynthesis in the Kandutsch-Russel pathway, the reduction of 7-dehydrocholesterol (7DHC) to cholesterol. 7DHC can be acted on by a range of other enzymes including CYP27A1 and CYP11A1, as well as by UVB radiation, producing a number of derivatives including hydroxy ...
Robert C Tuckey, Edith K Y Tang
exaly   +4 more sources

Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol [PDF]

Journal of Lipid Research, 2018
Regulating blood cholesterol (Chol) levels by pharmacotherapy has successfully improved cardiovascular health. There is growing interest in the role of Chol precursors in the treatment of diseases.
Phillip A. Wages, Hye-Young Kim, Zeljka Korade   +2 more
exaly   +4 more sources

Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction [PDF]

Biotechnology for Biofuels, 2018
Background 7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3.
Xiao-Jing Guo, Wen-Hai Xiao, Ying Wang, Ming-Dong Yao, Bo-Xuan Zeng, Hong Liu, Guang-Rong Zhao, Ying-Jin Yuan   +7 more
doaj   +5 more sources

7-Dehydrocholesterol dictates ferroptosis sensitivity. [PDF]

Nature
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid peroxidation, has been implicated in multiple diseases, including cancer1-3, degenerative disorders4 and organ ischaemia-reperfusion injury (IRI)5,6. Here, using genome-wide CRISPR-Cas9 screening, we identified that the enzymes involved in distal cholesterol ...
Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P.   +24 more
europepmc   +3 more sources

Localization and biosynthesis of 7-dehydrocholesterol in rat skin

Journal of Lipid Research, 1964
By differential assay, the concentration of 7-dehydrocholesterol in the dead keratin layer, the epidermal mucosa, the sebaceous glands and associated appendages of the epidermis, and the dermis of rat skin was determined; 85% of the 7-dehydrocholesterol ...
J.L. Gaylor, Frances M. Sault
doaj   +3 more sources

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone [PDF]

Translational Psychiatry, 2022
Major depressive disorder (MDD) is a common, disabling, and heterogeneous condition that responds unpredictably to current treatments. We previously showed an association between depressive symptoms and plasma concentrations of two cholesterol precursors,
Basar Cenik, Jayme M. Palka, Bonne M. Thompson, Jeffrey G. McDonald, Carol A. Tamminga, Can Cenik, E. Sherwood Brown   +6 more
doaj   +2 more sources

Oxidation of 7-dehydrocholesterol and desmosterol by human cytochrome P450 46A1[S]

Journal of Lipid Research, 2014
Cytochrome P450 (P450 or CYP) 46A1 is expressed in brain and has been characterized by its ability to oxidize cholesterol to 24S-hydroxycholesterol. In addition, the same enzyme is known to further oxidize 24S-hydroxycholesterol to the 24,25- and 24,27 ...
Ned A. Porter, Sandeep Goyal, Frederick Peter Guengerich   +2 more
exaly   +3 more sources

7-Dehydrocholesterol attenuates osteoarthritis by synergistically inhibiting oxidative stress, inflammation, and ferroptosis in macrophages [PDF]

Frontiers in Pharmacology
ObjectiveOsteoarthritis (OA) is a prevalent degenerative disorder affecting joints, characterized by progressive cartilage deterioration, inflammation of the synovium, and structural damage to subchondral bone.
Wenchao Zhang, Mengru Hua, Xinyu Zhao, Guangxin Sun, Yuheng Pan, Le Miao, Xuzhuo Chen, Xuzhuo Chen, Shanyong Zhang   +8 more
doaj   +2 more sources

Identifying Molecular Fragments That Drive 7-Dehydrocholesterol Elevation. [PDF]

ACS Pharmacol Transl Sci, 2022
Medications having the unwanted side effect of inhibiting 7-dehydrocholesterol reductase (DHCR7), one of the last enzymes in the cholesterol biosynthesis pathway, account for about 300 million yearly prescriptions in the United States. Many of these drugs are currently prescribed to pregnant women.
Ghersi D, Genaro-Mattos TC.
europepmc   +3 more sources