Results 1 to 10 of about 320 (132)

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey [PDF]

Molecules, 2020
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP11A1
, Adrian Fabisiak, Robert Tuckey
exaly   +6 more sources

Localization and biosynthesis of 7-dehydrocholesterol in rat skin

Journal of Lipid Research, 1964
By differential assay, the concentration of 7-dehydrocholesterol in the dead keratin layer, the epidermal mucosa, the sebaceous glands and associated appendages of the epidermis, and the dermis of rat skin was determined; 85% of the 7-dehydrocholesterol ...
J.L. Gaylor, Frances M. Sault
doaj   +3 more sources

Metabolic engineering of Saccharomyces cerevisiae for 7-dehydrocholesterol overproduction [PDF]

Biotechnology for Biofuels, 2018
Background 7-Dehydrocholesterol (7-DHC) has attracted increasing attentions due to its great medical value and the enlarging market demand of its ultraviolet-catalyzed product vitamin D3.
Xiao-Jing Guo, Wen-Hai Xiao, Ying Wang, Ming-Dong Yao, Bo-Xuan Zeng, Hong Liu, Guang-Rong Zhao, Ying-Jin Yuan   +7 more
doaj   +3 more sources

Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol

Journal of Lipid Research, 2018
Regulating blood cholesterol (Chol) levels by pharmacotherapy has successfully improved cardiovascular health. There is growing interest in the role of Chol precursors in the treatment of diseases.
Phillip Wages, Hye-Young Kim, Ned Porter   +2 more
exaly   +3 more sources

Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice

Biomolecules, 2022
Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ).
Marta Balog, Allison C Anderson, Marija Heffer, Zeljka Korade, Karoly Mirnics   +4 more
doaj   +1 more source

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally[S]

Journal of Lipid Research, 2015
Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate ...
Winnie Luu, Gene Hart-Smith, Laura J. Sharpe, Andrew J. Brown   +3 more
doaj   +1 more source

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver

Journal of Lipid Research, 1999
The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3β-hydroxysterol Δ7-reductase, the final enzyme in the cholesterol biosynthetic pathway.
Akira Honda, Gerald Salen, Sarah Shefer, Ashok K. Batta, Megumi Honda, Guorong Xu, G. Stephen Tint, Yasushi Matsuzaki, Junichi Shoda, Naomi Tanaka   +9 more
doaj   +1 more source

Vulnerability of DHCR7+/− mutation carriers to aripiprazole and trazodone exposure

Journal of Lipid Research, 2017
Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-dehydrocholesterol reductase (DHCR)7 with a heterozygous (HET) carrier frequency of 1–3%.
Zeljka Korade, Thiago C. Genaro-Mattos, Keri A. Tallman, Wei Liu, Krassimira A. Garbett, Katalin Koczok, Istvan Balogh, Karoly Mirnics, Ned A. Porter   +8 more
doaj   +1 more source

Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol [PDF]

Organic & Biomolecular Chemistry, 2015
We report here that H-atom tunneling facilitates the propagation step in the tocopherol-mediated peroxidation (TMP) of 7-dehydrocholesterol. This process likely becomes a major propagation pathway when radical intermediates are isolated in cellular organelles or lipid particles such as low-density lipoproteins.
H, Muchalski, L, Xu, N A, Porter
openaire   +2 more sources

Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome.

Journal of Lipid Research, 1996
The impaired conversion of 7-dehydrocholesterol to cholesterol, as a result of a permanent inhibition of the activity of 7-dehydrocholesterol-delta 7-reductase, has been reported in the Smith-Lemli-Opitz (SLO) syndrome (1, 2).
C Wolf, F Chevy, J Pham, M Kolf-Clauw, D Citadelle, N Mulliez, C Roux   +6 more
doaj   +1 more source