Results 31 to 40 of about 7,464,333 (166)

Identification of 8-dehydrocholesterol (cholesta-5,8-dien-3 beta-ol) in patients with Smith-Lemli-Opitz syndrome.

Journal of Lipid Research, 1995
Cholesta-5,8-dien-3 beta-ol (8-dehydrocholesterol) and cholesta-5,7-dien-3 beta-ol (7-dehydrocholesterol) were isolated from the fecal neutral sterol fraction from homozygotes with Smith-Lemli-Opitz syndrome.
A K Batta, G S Tint, S Shefer, D Abuelo, G Salen   +4 more
doaj   +1 more source

Defective conversion of 7-dehydrocholesterol to cholesterol in cultured skin fibroblasts from Smith-Lemli-Opitz syndrome homozygotes

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is a common birth defect syndrome characterized biochemically by low plasma cholesterol levels and high concentrations of the cholesterol precursor 7-dehydrocholesterol.
A Honda, G S Tint, G Salen, A K Batta, T S Chen, S Shefer   +5 more
doaj   +1 more source

Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active Compounds in Neuro2a Cells. [PDF]

Chem Res Toxicol, 2016
A small library of pharmacologically active compounds (the NIH Clinical Collection) was assayed in Neuro2a cells to determine their effect on the last step in the biosynthesis of cholesterol, the transformation of 7-dehydrocholesterol (7-DHC) to ...
Kim HY, Korade Z, Tallman KA, Liu W, Weaver CD, Mirnics K, Porter NA.   +6 more
europepmc   +2 more sources

Effect of a new inhibitor of cholesterol biosynthesis (AY 9944) on serum and tissue sterols in the rat

Journal of Lipid Research, 1966
AY 9944 is a novel inhibitor of cholesterol biosynthesis which appears to act on the Δ7-reductase enzyme, interfering with the conversion of 7-dehydrocholesterol to cholesterol.
L. Horlick
doaj   +1 more source

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Journal of Lipid Research, 2022
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited.
Marta Balog, Allison Anderson, Thiago C. Genaro-Mattos, Zeljka Korade, Karoly Mirnics   +4 more
doaj   +1 more source

Voltammetric Determination of 7-Dehydrocholesterol as a Biomarker of Smith-Lemli-Opitz Syndrom [PDF]

, 2020
The aim of this thesis was the development of a voltammetric method for the determination of 7-dehydrocholesterol as a biomarker of congenital disease Smith-Lemli-Opitz syndrome.
Zárybnická, Adéla
core  

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production

Biomolecules, 2021
24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj   +1 more source

Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol Δ7-reductase, on serum and tissue lipids in the rat

Journal of Lipid Research, 1968
The effect of long-term administration of AY-9944, a specific inhibitor of cholesterol biosynthesis, was examined in rats maintained on diets with low and high cholesterol and fat content.
D. Dvornik, P. Hill
doaj   +1 more source

Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression

Journal of Lipid Research, 2005
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes.
Carlos Fernández, Miguel Martín, Diego Gómez-Coronado, Miguel A. Lasunción   +3 more
doaj   +1 more source