On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO [PDF]
Journal of Lipid Research, 2014 A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product.
Ingemar Björkhem +11 more
doaj +4 more sources
Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis [PDF]
Nature CommunicationsRecent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood.
Naoya Yamada +19 more
doaj +3 more sources
Alleviating Redox Imbalance Enhances 7-Dehydrocholesterol Production in Engineered Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2015 Maintaining redox balance is critical for the production of heterologous secondary metabolites, whereas on various occasions the native cofactor balance does not match the needs in engineered microorganisms.
Wan Su +5 more
doaj +3 more sources
Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol [PDF]
Journal of NanobiotechnologyBackground Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge.
Jianwen Li +17 more
doaj +2 more sources
Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. [PDF]
Org Biomol Chem, 2015 We report here that H-atom tunneling facilitates the propagation step in the tocopherol-mediated peroxidation (TMP) of 7-dehydrocholesterol. This process likely becomes a major propagation pathway when radical intermediates are isolated in cellular organelles or lipid particles such as low-density lipoproteins.
Muchalski H, Xu L, Porter NA.
europepmc +4 more sources
Early stages of ecdysteroid biosynthesis. The role of 7-dehydrocholesterol
, 1986 The synthesis of [4-14C]cholesta-4,6-dien-3-one and [4-14C]3β-hydroxy-5α-cholestan-6-one is described. Both [4-14C]cholest-4-en-3-one and [4-14C]cholesta-4,6-dien-3-one were not incorporated significantly into ecdysteroids compared to [1α,2α-3H ...
Nali, Micaela +3 more
core +10 more sources
A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome[S] [PDF]
Journal of Lipid Research, 2014 We describe a highly sensitive method for the detection of 7-dehydrocholesterol (7-DHC), the biosynthetic precursor of cholesterol, based on its reactivity with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) in a Diels-Alder cycloaddition reaction.
Wei Liu +5 more
doaj +2 more sources
Cryopreservation and evaluation of Akkaraman ram semen with 7-dehydrocholesterol
Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2018 Bu calisma, tris sulandiricisina 7-dehidrokolesterol ile doyurulmus siklodekstrin bilesimi (7-DCLC) eklenerek dondurmacozdurme sonrasi in vitro sonuclarini degerlendirmek uzere yapildi. Calismada yerli bir irk olarak uc adet Akkaraman koc kullanildi.
İNANÇ, Muhammed Enes +2 more
openaire +4 more sources
Ultrafast Optical Control of Ring-Opening and Isomerization in 7-Dehydrocholesterol and Stilbene. [PDF]
, 2015 7-dehydrocholesterol and stilbene are model systems for the molecules used within the fast-growing field of molecular motors and switches. One of the significant problems facing the development of effective motors and switches is the quantum yield of ...
Smith, Broc D.
core +7 more sources
Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice
Biomolecules, 2022 Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ).
Marta Balog +4 more
doaj +1 more source