Results 1 to 10 of about 172 (75)

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver

Journal of Lipid Research, 1999
The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3β-hydroxysterol Δ7-reductase, the final enzyme in the cholesterol biosynthetic pathway.
Akira Honda, Gerald Salen, Sarah Shefer, Ashok K. Batta, Megumi Honda, Guorong Xu, G. Stephen Tint, Yasushi Matsuzaki, Junichi Shoda, Naomi Tanaka   +9 more
doaj   +1 more source

Occurrence of isomeric dehydrocholesterols in human plasma.

Journal of Lipid Research, 1991
Three isomeric dehydrocholesterols were found in plasma from healthy subjects and patients with abnormal production or metabolism of cholesterol.
M Axelson
doaj   +1 more source

Markedly increased tissue concentrations of 7-dehydrocholesterol combined with low levels of cholesterol are characteristic of the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is an autosomal recessive birth defect (frequency 1:20,000-1:40,000) that results in profound mental retardation, physical deformities, and failure to thrive.
G S Tint, M Seller, R Hughes-Benzie, A K Batta, S Shefer, D Genest, M Irons, E Elias, G Salen   +8 more
doaj   +1 more source

Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations

Journal of Lipid Research, 1967
Chromatographic methods for the separation of 24- and 25-dehydrocholesterols are described. The purities of three commercial samples of 24-dehydrocholesterol examined by thin-layer and gas-liquid chromatography were only 42, 79, and 80%, respectively; a ...
James A. Svoboda, Malcolm J. Thompson
doaj   +1 more source

Neutral sterols of rat epididymis: high concentrations of dehydrocholesterols in rat caput epididymidis

Journal of Lipid Research, 2001
Phospholipids and sterols are known to have multiple functions in reproductive tissue of mammals. High concentrations of the cholesterol precursor desmosterol have been described in testis, epididymis, and spermatozoa of various species.
Bernhard Lindenthal, Tayseer A. Aldaghlas, Joanne K. Kelleher, Stephan M. Henkel, René Tolba, Gerhard Haidl, Klaus von Bergmann   +6 more
doaj   +1 more source

Prenatal diagnosis of holoprosencephaly associated with Smith–Lemli–Opitz syndrome (SLOS) in a 46,XX fetus

Taiwanese Journal of Obstetrics & Gynecology, 2017
Objective: To show the importance of measuring cholesterol precursor levels in amniotic fluid in all pregnancies with ultrasound features (such as holoprosencephaly) suggestive of Smith–Lemli–Opitz syndrome (SLOS), after exclusion of chromosomal ...
André Travessa, Patrícia Dias, Pedro Rocha, Ana Berta Sousa   +3 more
doaj   +1 more source

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone. [PDF]

Transl Psychiatry, 2022
Cenik B, Palka JM, Thompson BM, McDonald JG, Tamminga CA, Cenik C, Brown ES.   +6 more
europepmc   +1 more source

A newly developed and validated LC-MS/MS method for measuring 7-dehydrocholesterol (7DHC) concentration in human skin: a tool for vitamin D photobiology research. [PDF]

Photochem Photobiol Sci, 2022
Borecka O, Rhodes LE, Webb AR, Dutton JJ, Fraser WD.   +4 more
europepmc   +1 more source

Influence of Seasonal Vitamin D Changes on Clinical Manifestations of Rheumatoid Arthritis and Systemic Sclerosis. [PDF]

Front Immunol, 2021
Cutolo M, Soldano S, Sulli A, Smith V, Gotelli E.   +4 more
europepmc   +1 more source

Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites. [PDF]

J Steroid Biochem Mol Biol, 2021
Tuckey RC, Tang EKY, Chen YA, Slominski AT.   +3 more
europepmc   +1 more source