Results 1 to 10 of about 226 (125)

Separation of 24- and 25-dehydrocholesterols; and the impure state of commercial desmosterol preparations

Journal of Lipid Research, 1967
Chromatographic methods for the separation of 24- and 25-dehydrocholesterols are described. The purities of three commercial samples of 24-dehydrocholesterol examined by thin-layer and gas-liquid chromatography were only 42, 79, and 80%, respectively; a ...
James A. Svoboda, Malcolm J. Thompson
doaj   +2 more sources

Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites. [PDF]

J Steroid Biochem Mol Biol, 2021
7-Dehydrocholesterol reductase (DHCR7) catalyses the final step of cholesterol biosynthesis in the Kandutsch-Russel pathway, the reduction of 7-dehydrocholesterol (7DHC) to cholesterol. 7DHC can be acted on by a range of other enzymes including CYP27A1 and CYP11A1, as well as by UVB radiation, producing a number of derivatives including hydroxy ...
Tuckey RC, Tang EKY, Chen YA, Slominski AT.   +3 more
europepmc   +3 more sources

Occurrence of isomeric dehydrocholesterols in human plasma.

Journal of Lipid Research, 1991
Three isomeric dehydrocholesterols were found in plasma from healthy subjects and patients with abnormal production or metabolism of cholesterol.
M Axelson
doaj   +3 more sources

Detection of 7-Dehydrocholesterol and Vitamin D3 Derivatives in Honey. [PDF]

Molecules, 2020
20(S)-Hydroxyvitamin D3 (20(OH)D3) is an endogenous metabolite produced by the action of CYP11A1 on the side chain of vitamin D3 (D3). 20(OH)D3 can be further hydroxylated by CYP11A1, CYP27A1, CYP24A1 and/or CYP27B1 to several hydroxyderivatives. CYP11A1 also hydroxylates D3 to 22-monohydroxyvitamin D3 (22(OH)D3), which is detectable in the epidermis ...
Kim TK, Atigadda V, Brzeminski P, Fabisiak A, Tang EKY, Tuckey RC, Slominski AT.   +6 more
europepmc   +6 more sources

Tunneling in tocopherol-mediated peroxidation of 7-dehydrocholesterol. [PDF]

Org Biomol Chem, 2015
We report here that H-atom tunneling facilitates the propagation step in the tocopherol-mediated peroxidation (TMP) of 7-dehydrocholesterol. This process likely becomes a major propagation pathway when radical intermediates are isolated in cellular organelles or lipid particles such as low-density lipoproteins.
Muchalski H, Xu L, Porter NA.
europepmc   +4 more sources

7-Dehydrocholesterol dictates ferroptosis sensitivity. [PDF]

Nature
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid peroxidation, has been implicated in multiple diseases, including cancer1-3, degenerative disorders4 and organ ischaemia-reperfusion injury (IRI)5,6. Here, using genome-wide CRISPR-Cas9 screening, we identified that the enzymes involved in distal cholesterol ...
Li Y, Ran Q, Duan Q, Jin J, Wang Y, Yu L, Wang C, Zhu Z, Chen X, Weng L, Li Z, Wang J, Wu Q, Wang H, Tian H, Song S, Shan Z, Zhai Q, Qin H, Chen S, Fang L, Yin H, Zhou H, Jiang X, Wang P.   +24 more
europepmc   +3 more sources

Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7α-hydroxylase and 27-hydroxylase activities in rat liver

Journal of Lipid Research, 1999
The Smith-Lemli-Opitz syndrome (SLOS) is a congenital birth defect syndrome caused by a deficiency of 3β-hydroxysterol Δ7-reductase, the final enzyme in the cholesterol biosynthetic pathway.
Akira Honda, Gerald Salen, Sarah Shefer, Ashok K. Batta, Megumi Honda, Guorong Xu, G. Stephen Tint, Yasushi Matsuzaki, Junichi Shoda, Naomi Tanaka   +9 more
doaj   +1 more source

Markedly increased tissue concentrations of 7-dehydrocholesterol combined with low levels of cholesterol are characteristic of the Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 1995
The Smith-Lemli-Opitz syndrome is an autosomal recessive birth defect (frequency 1:20,000-1:40,000) that results in profound mental retardation, physical deformities, and failure to thrive.
G S Tint, M Seller, R Hughes-Benzie, A K Batta, S Shefer, D Genest, M Irons, E Elias, G Salen   +8 more
doaj   +1 more source

Neutral sterols of rat epididymis: high concentrations of dehydrocholesterols in rat caput epididymidis

Journal of Lipid Research, 2001
Phospholipids and sterols are known to have multiple functions in reproductive tissue of mammals. High concentrations of the cholesterol precursor desmosterol have been described in testis, epididymis, and spermatozoa of various species.
Bernhard Lindenthal, Tayseer A. Aldaghlas, Joanne K. Kelleher, Stephan M. Henkel, René Tolba, Gerhard Haidl, Klaus von Bergmann   +6 more
doaj   +1 more source

Prenatal diagnosis of holoprosencephaly associated with Smith–Lemli–Opitz syndrome (SLOS) in a 46,XX fetus

Taiwanese Journal of Obstetrics & Gynecology, 2017
Objective: To show the importance of measuring cholesterol precursor levels in amniotic fluid in all pregnancies with ultrasound features (such as holoprosencephaly) suggestive of Smith–Lemli–Opitz syndrome (SLOS), after exclusion of chromosomal ...
André Travessa, Patrícia Dias, Pedro Rocha, Ana Berta Sousa   +3 more
doaj   +1 more source