Results 31 to 40 of about 226 (125)

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson, Maria Teresa Fiorenza   +1 more
wiley   +1 more source

Vitamin D receptor signaling in inflammatory senescence–associated skin aging: Mechanisms and therapeutic potentials

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
Vitamin D receptor (VDR) signaling is implicated in inflammatory senescence‐associated skin aging, a growing health concern in aging populations where cellular senescence and chronic inflammation converge to create complex pathophysiological conditions.
Liancheng Guan, Fan Yang, Meijuan Li, Yujia Chen, Zexin Zhao, Hongxia Li, Deping Luo, Qian Li, Yunzhi Chen   +8 more
wiley   +1 more source

Bioinspired Aerobic Oxidation to Functionalize the CD Ring of the Steroid Framework: Synthesis and Stereochemical Assignments of Gargalol C and Related Oxysterols

ChemistryEurope, Volume 4, Issue 6, June 2026.
Bioinspired aerobic oxidation of the CD ring part of 5,6‐α‐epoxysterols was achieved by two means. The study not only led to the first syntheses and configurational (re)assignments of naturally occurring bioactive C14‐ or C15‐hydroxysterols but also gives valuable insights into the biosynthetic pathways of advanced oxysterols. A series of NMR and X‐ray
Hinata Togo, Yui Kanda, Shoji Kobayashi
wiley   +1 more source

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

A c.89G>C p.(Gly30Ala) Variant in the DHCR7 Gene as a Cause of a Mild Phenotype in the Smith‐Lemli‐Opitz Syndrome

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
Smith‐Lemli‐Opitz syndrome (SLOS) is an autosomal recessive disorder caused by pathogenic variants in the DHCR7 gene. Based on our observations and a review of the literature, we demonstrate that the NM_001360.2(DHCR7):c.89G>C p.(Gly30Ala) variant is associated with a mild SLOS phenotype.
Júlia Martinková, Emílie Vyhnálková, Martin Schwarz, Miroslava Balaščaková, Veronika Biddle, Romana Borská, Lenka Fajkusová, Lukáš Ryba, Anna Křepelová   +8 more
wiley   +1 more source

The Conversion of 7-Dehydrocholesterol into Cholesterol [PDF]

Biochemical Journal, 1966
D C, Wilton, M, Akhtar, K A, Munday
openaire   +3 more sources

Smith-Lemli-Opitz syndrome : a disorder of cholesterol synthesis : diagnosis, treatment and pathogenetic aspects

, 2002
In 1993 it was first suggested that the Smith-Lemli-Opitz syndrome (SLOS), described almost 30 years earlier as a malformation syndrome, is caused by defective synthesis of cholesterol.
Lena Starck (19528093)
core  

Cryopreservation and evaluation of Akkaraman ram semen with 7-dehydrocholesterol

Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2018
Bu calisma, tris sulandiricisina 7-dehidrokolesterol ile doyurulmus siklodekstrin bilesimi (7-DCLC) eklenerek dondurmacozdurme sonrasi in vitro sonuclarini degerlendirmek uzere yapildi. Calismada yerli bir irk olarak uc adet Akkaraman koc kullanildi.
İNANÇ, Muhammed Enes, UYSAL, Olgun, ATA, Ayhan   +2 more
openaire   +3 more sources

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone. [PDF]

Transl Psychiatry, 2022
Cenik B, Palka JM, Thompson BM, McDonald JG, Tamminga CA, Cenik C, Brown ES.   +6 more
europepmc   +1 more source