Results 41 to 50 of about 7,464,333 (166)

A New Class of Selective and Potent 7‑Dehydrocholesterol Reductase Inhibitors

, 2016
We prepared a number of N-phenethyltetrahydroisoquinolines structurally related to protoberberines. They were tested for activity against bacteria, fungi, and human leukemia HL-60 cells and also for inhibition of biosynthesis: ergosterol in yeasts and ...
Aline Horling (2044264), Richard Barthel (2044267), Peter Imming (1574989), Franz Bracher (458039), Christoph Müller (1592521)   +4 more
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Sterol balance in the Smith-Lemli-Opitz syndrome: reduction in whole body cholesterol synthesis and normal bile acid production

Journal of Lipid Research, 2000
The Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation/mental retardation syndrome caused by a deficiency of the enzyme 7-dehydrocholesterol Δ7-reductase.
Robert D. Steiner, Leesa M. Linck, Donna P. Flavell, Don S. Lin, William E. Connor   +4 more
doaj   +1 more source

Sterols in blood of normal and Smith-Lemli-Opitz subjects

Journal of Lipid Research, 2001
Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of noncholesterol sterols, such as 7- and 8-dehydrocholesterol.
Benfang Ruan, William K. Wilson, Jihai Pang, Nicolas Gerst, Frederick D. Pinkerton, James Tsai, Richard I. Kelley, Frank G. Whitby, Dianna M. Milewicz, James Garbern, George J. Schroepfer, Jr.   +10 more
doaj   +1 more source

Syntheses of 7-dehydrocholesterol peroxides and their improved anticancer activity and selectivity over ergosterol peroxide

, 2017
Three 7-dehydrocholesterol peroxides were photochemically prepared and their anticancer activity was studied.
Bao-wen Zhang, Xue-song Wang, Na-na Tian, Qian-xiong Zhou, Chao Li, Na Tian, Yuan-jun Hou   +6 more
core   +1 more source

A rapid screening procedure for cholesterol and dehydrocholesterol by electrospray ionization tandem mass spectrometry

Journal of Lipid Research, 2001
The mono-(dimethylaminoethyl) succinyl (MDMAES) ester is a new derivative for rapid, mild, and sensitive electrospray ionization tandem mass spectrometry (ESI-MS/MS) analysis of cholesterol and dehydrocholesterol.
D.W. Johnson, H.J. ten Brink, C. Jakobs
doaj   +1 more source

Biosynthesis of squalene and sterols by rat aorta

Journal of Lipid Research, 1971
The synthesis of nonsaponifiable compounds from radioactive mevalonate by segments of adult rat aorta was studied in vitro. The labeled products consisted largely of substances with the chromatographic and chemical behavior of squalene, lanosterol ...
MARIE M. DALY
doaj   +1 more source

Oxidation of 7-dehydrocholesterol by a mouse liver microsomal system dependent on reduced pyridine nucleotides

Journal of Lipid Research, 1966
Aerobic incubation of 7-dehydrocholesterol with mouse liver microsomes in the presence of a detergent, an iron salt, and NADH or NADPH resulted in the conversion of the sterol to more polar products.
A.A. Kandutsch
doaj   +1 more source

Development of electroanalytical methods for detection of cholesterol and 7-dehydrocholesterol [PDF]

, 2018
The aim of this Thesis is development of electroanalytical methods for determination of cholesterol and 7-dehydrocholesterol on boron doped diamond electrodes based on electrochemical oxidation of products of acid-induced dehydration reaction.
Benešová, Lenka
core  

Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome

Journal of Lipid Research, 2011
Treatment of Sprague-Dawley rats with AY9944, an inhibitor of 3β-hydroxysterol-Δ7-reductase (Dhcr7), leads to elevated levels of 7-dehydrocholesterol (7-DHC) and reduced levels of cholesterol in all biological tissues, mimicking the key biochemical ...
Libin Xu, Wei Liu, Lowell G. Sheflin, Steven J. Fliesler, Ned A. Porter   +4 more
doaj   +1 more source

The Photochemical Dehydrogenation of Ergosterol and 7-Dehydrocholesterol [PDF]

Bulletin of the Chemical Society of Japan, 1939
Abstract Ergopinacone and 7-dehydrocholesterol-pinacone have been prepared by two different methods, viz., the boiling method and the carbon dioxide method. The products obtained by the two methods as well as diacetates and dibenzoates derived from them have been compared.
openaire   +1 more source