Results 61 to 70 of about 7,464,333 (166)

The Conversion of 7-Dehydrocholesterol into Cholesterol [PDF]

Biochemical Journal, 1966
D C, Wilton, M, Akhtar, K A, Munday
openaire   +3 more sources

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2010
Smith-Lemli-Opitz syndrome (SLOS) is a metabolic and developmental disorder caused by mutations in the gene encoding the enzyme 7-dehydrocholesterol reductase (Dhcr7).
Zeljka Korade, Libin Xu, Richard Shelton, Ned A. Porter   +3 more
doaj   +1 more source

Biosynthesis of Δ7-cholesten-3Β-ol, Δ5,7-cholestadien-3Β-ol, and Δ5-cholesten-3Β-ol by guinea pig intestinal mucosa in vitro

Journal of Lipid Research, 1966
Methods were developed for the separation and determination of the various 27-carbon sterols of intestinal mucosa by means of thin-layer chromatography.
Robert K. Ockner, Leonard Laster
doaj   +1 more source

7-Dehydrocholesterol–dependent proteolysis of HMG-CoA reductase suppresses sterol biosynthesis in a mouse model of Smith-Lemli-Opitz/RSH syndrome [PDF]

, 2001
Smith-Lemli-Opitz/RSH syndrome (SLOS), a relatively common birth-defect mental-retardation syndrome, is caused by mutations in DHCR7, whose product catalyzes an obligate step in cholesterol biosynthesis, the conversion of 7-dehydrocholesterol to ...
Shefer, Sarah, Heather Waage-Baudet, Moebius, Fabian F., Hongwei Yu, Gerald Salen, G.S. Tint, Kimberly Kluckman, Sylvia Hiller, Chen, Thomas, Xu, Liwen, Xu, Guorong, Salen, Gerald, Kathleen Sulik, Asaoka, Hitoshi, Gene C. Ness, Fitzky, Barbara U., Maeda, Nobuyo, Hiller, Sylvia, Ness, Gene C., Liwen Xu, Thomas Chen, Tint, G.S., Simoni, Robert D., Batta, Ashok K., Robert D. Simoni, Fabian F. Moebius, Nobuyo Maeda, Yu, Hongwei, Shailendra B. Patel, Patel, Shailendra B., Ashok K. Batta, Guorong Xu, Barbara U. Fitzky, Hartmut Glossmann, Glossmann, Hartmut, Waage-Baudet, Heather, Sulik, Kathleen, Sarah Shefer, Kluckman, Kimberly, Hitoshi Asaoka   +39 more
core   +1 more source

Development of electroanalytical methods for detection of cholesterol, 7-dehydrocholesterol and cholecalciferol [PDF]

Látky steroidní povahy jsou nedílnou součástí všech organismů. Patří mezi ně například žlučové kyseliny, steroidní hormony nebo některé vitaminy. Cholesterol je lipofilní složkou buněčných membrán.
Benešová, Lenka
core   +1 more source

Regulation of rat hepatic 3β-hydroxysterol Δ7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation

Journal of Lipid Research, 1998
The mechanism for the catalytic reduction of the double bond at C-7,8 in 7-dehydrocholesterol by 3β-hydroxysterol Δ7-reductase was investigated by testing structurally related sterols as substrates and potential inhibitors. The hepatic smooth endoplasmic
S. Shefer, G. Salen, A. Honda, A.K. Batta, L.B. Nguyen, G.S. Tint, Y.A. Ioannou, R. Desnick   +7 more
doaj   +1 more source

Long-term effects of sterol depletion in C. elegans

Journal of Lipid Research, 2004
Three major long-term effects of sterol deprivation in Caenorhabditis elegans are described. 1) The life expectancy of sterol-deprived wild-type animals is decreased by more than 40%. Similar decreases are found in animals carrying mutations in the daf-9,
Mark Merris, Jessica Kraeft, G.S. Tint, John Lenard   +3 more
doaj   +1 more source

Downmodulation of cholesterol biosynthetic network governs activation of the innate immune response to Japanese encephalitis virus infection

Journal of Virology
Viruses remodel metabolic processes and utilize host lipids for different stages of their life cycle. Our earlier studies have shown that the flavivirus Japanese encephalitis virus (JEV) downmodulates several key proteins involved in sterol and lipid ...
Sakshi Khera, Kiran Bala Sharma, Yashwant Kumar, Manjula Kalia   +3 more
doaj   +1 more source

Smith-Lemli-Opitz syndrome: clinical and biochemical findings in Brazilian patients

Genetics and Molecular Biology, 2006
Smith-Lemli-Opitz syndrome (SLOS) or RSH syndrome comprises multiple congenital anomalies and mental retardation. The underlying defect is a deficiency in the activity of delta7-sterol reductase, which decreases cholesterol and increases 7 ...
Fernanda B. Scalco, Paulo A. Otto, Iguatemy L. Brunetti, Vania M. Cruzes, Danilo Moretti-Ferreira   +4 more
doaj   +1 more source

Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2013
Lipid modifications aid in regulating (and misregulating) protein function and localization. However, efficient methods to screen for a lipid's ability to modify proteins are not readily available.
Katherine Windsor, Thiago C. Genaro-Mattos, Hye-Young H. Kim, Wei Liu, Keri A. Tallman, Sayuri Miyamoto, Zeljka Korade, Ned A. Porter   +7 more
doaj   +1 more source