Results 61 to 70 of about 320 (132)

The Conversion of 7-Dehydrocholesterol into Cholesterol [PDF]

Biochemical Journal, 1966
D C, Wilton, M, Akhtar, K A, Munday
openaire   +3 more sources

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2010
Smith-Lemli-Opitz syndrome (SLOS) is a metabolic and developmental disorder caused by mutations in the gene encoding the enzyme 7-dehydrocholesterol reductase (Dhcr7).
Zeljka Korade, Libin Xu, Richard Shelton, Ned A. Porter   +3 more
doaj   +1 more source

Biosynthesis of Δ7-cholesten-3Β-ol, Δ5,7-cholestadien-3Β-ol, and Δ5-cholesten-3Β-ol by guinea pig intestinal mucosa in vitro

Journal of Lipid Research, 1966
Methods were developed for the separation and determination of the various 27-carbon sterols of intestinal mucosa by means of thin-layer chromatography.
Robert K. Ockner, Leonard Laster
doaj   +1 more source

Smith-Lemli-Opitz syndrome: clinical and biochemical findings in Brazilian patients

Genetics and Molecular Biology, 2006
Smith-Lemli-Opitz syndrome (SLOS) or RSH syndrome comprises multiple congenital anomalies and mental retardation. The underlying defect is a deficiency in the activity of delta7-sterol reductase, which decreases cholesterol and increases 7 ...
Fernanda B. Scalco, Paulo A. Otto, Iguatemy L. Brunetti, Vania M. Cruzes, Danilo Moretti-Ferreira   +4 more
doaj   +1 more source

Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol

Journal of Nanobiotechnology
Background Ferroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge.
Jianwen Li, Shuyue Zhan, Wei Yang, He Zhang, Xinrui Ma, Fanghui Chen, Amy Li, Pakteema Tong, Fangchao Jiang, Zhengwei Cao, Ian Delahunty, Jiayi Wang, Yufei Wu, Zhi Liu, Zibo Li, Yong Teng, Libin Xu, Jin Xie   +17 more
doaj   +1 more source

Downmodulation of cholesterol biosynthetic network governs activation of the innate immune response to Japanese encephalitis virus infection

Journal of Virology
Viruses remodel metabolic processes and utilize host lipids for different stages of their life cycle. Our earlier studies have shown that the flavivirus Japanese encephalitis virus (JEV) downmodulates several key proteins involved in sterol and lipid ...
Sakshi Khera, Kiran Bala Sharma, Yashwant Kumar, Manjula Kalia   +3 more
doaj   +1 more source

Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2013
Lipid modifications aid in regulating (and misregulating) protein function and localization. However, efficient methods to screen for a lipid's ability to modify proteins are not readily available.
Katherine Windsor, Thiago C. Genaro-Mattos, Hye-Young H. Kim, Wei Liu, Keri A. Tallman, Sayuri Miyamoto, Zeljka Korade, Ned A. Porter   +7 more
doaj   +1 more source

Regulation of rat hepatic 3β-hydroxysterol Δ7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation

Journal of Lipid Research, 1998
The mechanism for the catalytic reduction of the double bond at C-7,8 in 7-dehydrocholesterol by 3β-hydroxysterol Δ7-reductase was investigated by testing structurally related sterols as substrates and potential inhibitors. The hepatic smooth endoplasmic
S. Shefer, G. Salen, A. Honda, A.K. Batta, L.B. Nguyen, G.S. Tint, Y.A. Ioannou, R. Desnick   +7 more
doaj   +1 more source

Cryopreservation and evaluation of Akkaraman ram semen with 7-dehydrocholesterol

Ankara Üniversitesi Veteriner Fakültesi Dergisi, 2018
Bu calisma, tris sulandiricisina 7-dehidrokolesterol ile doyurulmus siklodekstrin bilesimi (7-DCLC) eklenerek dondurmacozdurme sonrasi in vitro sonuclarini degerlendirmek uzere yapildi. Calismada yerli bir irk olarak uc adet Akkaraman koc kullanildi.
İNANÇ, Muhammed Enes, UYSAL, Olgun, ATA, Ayhan   +2 more
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7-Dehydrocholesterol attenuates osteoarthritis by synergistically inhibiting oxidative stress, inflammation, and ferroptosis in macrophages

Frontiers in Pharmacology
ObjectiveOsteoarthritis (OA) is a prevalent degenerative disorder affecting joints, characterized by progressive cartilage deterioration, inflammation of the synovium, and structural damage to subchondral bone.
Wenchao Zhang, Mengru Hua, Xinyu Zhao, Guangxin Sun, Yuheng Pan, Le Miao, Xuzhuo Chen, Xuzhuo Chen, Shanyong Zhang   +8 more
doaj   +1 more source