Frontiers in Cell and Developmental Biology, 2021 Pregnancy rates in ewes are markedly low after cervical insemination with frozen-thawed sperm. Sensitivity of ram sperm to freeze-thawing is related to the lipid composition of the membrane, particularly to its low sterol content.
Federico Hozbor +2 more
exaly +3 more sources
Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases [PDF]
MetabolitesAlthough the brain comprises only 2% of total body weight, it contains approximately 23% of the total cholesterol of the body. In the brain, cholesterol plays a critical role as a structural component of cell membranes and myelin sheaths.
Yoshimitsu Kiriyama +4 more
doaj +2 more sources
DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice [PDF]
iScienceSummary: The liver X receptor (LXR) is considered a therapeutic target for atherosclerosis treatment, but synthetic LXR agonists generally also cause hepatic steatosis and hypertriglyceridemia.
Xiaoke Ge +16 more
doaj +2 more sources
Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]
Cell Journal, 2023 Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi +8 more
doaj +1 more source
Characterisation of a desmosterol reductase involved in phytosterol dealkylation in the silkworm, Bombyx mori. [PDF]
PLoS ONE, 2011 Most species of invertebrate animals cannot synthesise sterols de novo and many that feed on plants dealkylate phytosterols (mostly C(29) and C(28)) yielding cholesterol (C(27)). The final step of this dealkylation pathway involves desmosterol reductase (
Leonora F Ciufo +4 more
doaj +1 more source
Insects, 2021 Arthropods, including insects, convert sterols into cholesterol due to the inability to synthesise cholesterol de novo. 24-dehydrocholesterol reductase (DHCR24) plays an important role in the conversion. Not only involving the cholesterol biosynthesis in
Yin Shan Isa Mack +3 more
doaj +1 more source
Generation and validation of a conditional knockout mouse model for desmosterolosis
Journal of Lipid Research, 2021 : The enzyme 3β-hydroxysterol-Δ24 reductase (DHCR24, EC 1.3.1.72) catalyzes the conversion of desmosterol to cholesterol and is obligatory for post-squalene cholesterol synthesis.
Babunageswararao Kanuri +7 more
doaj +1 more source
Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies
Brazilian Journal of Medical and Biological Research, 2012 Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial.
S.H. Kasmas +9 more
doaj +3 more sources
Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology
Journal of Lipid Research, 2012 We performed unbiased analysis of steroid-related compounds to identify novel Alzheimer's disease (AD) plasma biomarkers using liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy.
Yoshiaki Sato +5 more
doaj +1 more source
Basis for rapid efflux of biosynthetic desmosterol from cells
Journal of Lipid Research, 1998 Previous work shows that the efflux of biosynthetic desmosterol from cells is three times more efficient than that of cholesterol. To explain this difference, we labeled CHO-K1 cells with [3H]acetate precursor and measured sterols in the whole cells ...
Jane Ellen Phillips +2 more
doaj +1 more source