Results 31 to 40 of about 2,412 (177)

Unique lipids of primate spermatozoa: desmosterol and docosahexaenoic acid.

Journal of Lipid Research, 1993
Spermatozoa represent a tissue readily accessible for study after various exogenous perturbations. To characterize the lipid composition of monkey sperm and to establish a baseline from which dietary or pharmaceutical influences may then be evaluated, we
DS Lin, WE Connor, DP Wolf, M Neuringer, DL Hachey   +4 more
doaj   +1 more source

DHCR24 inhibitor SH42 increases desmosterol without preventing atherosclerosis development in mice

iScience
Summary: The liver X receptor (LXR) is considered a therapeutic target for atherosclerosis treatment, but synthetic LXR agonists generally also cause hepatic steatosis and hypertriglyceridemia.
Xiaoke Ge, Bram Slütter, Joost M. Lambooij, Enchen Zhou, Zhixiong Ying, Ceren Agirman, Marieke Heijink, Antoine Rimbert, Bruno Guigas, Johan Kuiper, Christoph Müller, Franz Bracher, Martin Giera, Sander Kooijman, Patrick C.N. Rensen, Yanan Wang, Milena Schönke   +16 more
doaj   +1 more source

Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis

Journal of Lipid Research, 2002
Triparanol, an inhibitor of desmosterol Δ24 reductase, produces a high rate of limb malformations in rat fetuses exposed at gestational day 10 (gd 10) to a single oral dose (150–200 mg/kg) given to the pregnant dam.
Françoise Chevy, Françoise Illien, Claude Wolf, Charles Roux   +3 more
doaj   +1 more source

Inhibition of DHCR24 activates LXRα to ameliorate hepatic steatosis and inflammation

EMBO Molecular Medicine, 2023
Liver X receptor (LXR) agonism has theoretical potential for treating NAFLD/NASH, but synthetic agonists induce hyperlipidemia in preclinical models.
Enchen Zhou, Xiaoke Ge, Hiroyuki Nakashima, Rumei Li, Hendrik J P van der Zande, Cong Liu, Zhuang Li, Christoph Müller, Franz Bracher, Yassene Mohammed, Jan Freark de Boer, Folkert Kuipers, Bruno Guigas, Christopher K Glass, Patrick C N Rensen, Martin Giera, Yanan Wang   +16 more
doaj   +1 more source

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

Frontiers in Nutrition, 2022
Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes, Eliton Juniro da Silva, Guilherme da Silva Ferreira, Sayonara Ivana Santos de Assis, Patrícia Miralda Cazita, Edna Regina Nakandakare, Vanessa Helena de Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintão   +8 more
doaj   +1 more source

Desmosterol May Replace Cholesterol in Lipid Membranes [PDF]

Biophysical Journal, 2005
Recently, knockout mice entirely lacking cholesterol have been described as showing only a mild phenotype. For these animals, synthesis of cholesterol was interrupted at the level of its immediate precursor, desmosterol. Since cholesterol is a major and essential constituent of mammalian cellular membranes, we asked whether cholesterol with its ...
Huster, Daniel, Scheidt, Holger A., Arnold, Klaus, Herrmann, Andreas, Müller, Peter   +4 more
openaire   +2 more sources

Pathway of cholesterol biosynthesis in the brain of the neonatal rat

Journal of Lipid Research, 1966
Suckling rats were killed at various intervals after intraperitoneal injection of acetate-1-14C and their brain sterols were analyzed by column, thin-layer, paper, and gas-liquid chromatography.
Thomas J. Holstein, William A. Fish, William M. Stokes   +2 more
doaj   +1 more source

The role of soluble fiber intake in patients under highly effective lipid-lowering therapy

Nutrition Journal, 2011
Background It has been demonstrated that statins can increase intestinal sterol absorption. Augments in phytosterolemia seems related to cardiovascular disease.
Rezende Vinicius M, Moreno Ronilson A, Borges Ney C, Helfenstein Tatiana, Moreira Flávio T, Kasmas Soraia H, Fonseca Francisco A, Ramos Silvia C, Silva Fernanda C, Izar Maria C   +9 more
doaj   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source

Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial

Journal of Lipid Research, 2010
Cholesterol homeostasis, defined as the balance between absorption and synthesis, influences circulating cholesterol concentrations and subsequent coronary heart disease (CHD) risk.
Nirupa R. Matthan, Nancy Resteghini, Michele Robertson, Ian Ford, James Shepherd, Chris Packard, Brendan M. Buckley, J. Wouter Jukema, Alice H. Lichtenstein, Ernst J. Schaefer   +9 more
doaj   +1 more source