Results 51 to 60 of about 2,350 (174)
Journal of Neurochemistry, Volume 170, Issue 6, June 2026.Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Myuri Ruthirakuhan +2 more
wiley +1 more source
Journal of Lipid Research, 2001 Phospholipids and sterols are known to have multiple functions in reproductive tissue of mammals. High concentrations of the cholesterol precursor desmosterol have been described in testis, epididymis, and spermatozoa of various species.
Bernhard Lindenthal +6 more
doaj +1 more source
Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]
Journal of Lipid Research, 2014 The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis, 3β ...
Winnie Luu +5 more
doaj +1 more source
Mapping molluscan endocrinology: a systematic and critical appraisal
Biological Reviews, Volume 101, Issue 2, Page 970-1002, April 2026.ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Konstantinos Panagiotidis +3 more
wiley +1 more source
Journal of Lipid Research, 2009 Data is limited on measures influencing cholesterol homeostasis in subjects at high risk of developing cardiovascular disease (CVD) relative to established risk factors.
Nirupa R. Matthan +6 more
doaj +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.The disruption of a cluster of three snoRNAs in the epithelium of the gut deregulates the lipid and sterol (including the cholesterol) homeostasis. At the whole‐organism level, this chronic deregulation, all along life, decreases lifespan and leads to neurodegenerative lesions in old flies.
Sara Al Issa +4 more
wiley +1 more source
Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles
Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger +6 more
wiley +1 more source
The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
Journal of Lipid Research, 2006 Mice with a targeted mutation of 3β-hydroxysterol Δ7-reductase (Dhcr7) that cannot convert 7-dehydrocholesterol to cholesterol were used to identify the origin of fetal sterols.
G.S. Tint +4 more
doaj +1 more source
Diabetes & Vascular Disease Research, 2022 Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol and oxysterol accumulation in macrophage foam cells.
Raphael S Pinto +10 more
doaj +1 more source
Lipids, Volume 61, Issue 1, Page 151-162, January 2026.ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He +4 more
wiley +1 more source