Results 61 to 70 of about 2,412 (177)

Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL

Journal of Lipid Research, 2003
The HDL Atherosclerosis Treatment Study (HATS) demonstrated a clinical benefit in coronary artery disease patients with low HDL cholesterol (HDL-C) levels treated with simvastatin and niacin (S-N) or S-N plus antioxidants (S-N+A) compared with ...
Nirupa R. Matthan, Ann Giovanni, Ernst J. Schaefer, B.Greg Brown, Alice H. Lichtenstein   +4 more
doaj   +1 more source

Cholesterol Deficiency Directs Autophagy‐Dependent Secretion of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 1, January 2026.
Inhibition of cholesterol biosynthesis within models of rare disease and cancer causes increased release of small extracellular vesicles (sEVs) with distinct biological properties. Mechanistically, cholesterol depletion leads to impaired autophagic flux, redirection of autophagosomes to late endosomes, and subsequently increased sEV secretion ...
Jazmine D. W. Yaeger, Sonali Sengupta, Austin L. Walz, Mayu Morita, Terry K. Morgan, Paola D. Vermeer, Kevin R. Francis   +6 more
wiley   +1 more source

Sterol Metabolism in Ovariectomized Rats: Potential Roles of Campesterol and 4β‐Hydroxycholesterol in Osteoporosis

Lipids, Volume 61, Issue 1, Page 151-162, January 2026.
ABSTRACT Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue. Lipid metabolism disorders may contribute to osteoporosis in postmenopausal women. Phytosterols and oxysterols (OC) are involved in lipid metabolism.
Wenzhao He, Sayuri Eguchi, Sen Wang, Yasutake Tanaka, Masao Sato   +4 more
wiley   +1 more source

Protective role of plant sterol and stanol esters in liver inflammation: insights from mice and humans. [PDF]

PLoS ONE, 2014
The inflammatory component of non-alcoholic steatohepatitis (NASH) can lead to irreversible liver damage. Therefore there is an urgent need to identify novel interventions to combat hepatic inflammation.
Jogchum Plat, Tim Hendrikx, Veerle Bieghs, Mike L J Jeurissen, Sofie M A Walenbergh, Patrick J van Gorp, Els De Smet, Maurice Konings, Anita C E Vreugdenhil, Yasmin Dias Guichot, Sander S Rensen, Wim A Buurman, Jan Willem M Greve, Dieter Lütjohann, Ronald P Mensink, Ronit Shiri-Sverdlov   +15 more
doaj   +1 more source

From Sea to Sweet: Seaweed's Role in Nutritious and Sustainable Confectionery

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 1, January 2026.
ABSTRACT Seaweed is increasingly recognized as a multifunctional ingredient in confectionery products, owing to its exceptional nutritional profile, functional properties, and environmental sustainability. This review highlights the integration of seaweed and seaweed‐derived compounds into a wide range of confectioneries, including chocolates, puddings,
Nima Mohammadi, Nikoo Ostovar
wiley   +1 more source

Neutral sterols of rat epididymis: high concentrations of dehydrocholesterols in rat caput epididymidis

Journal of Lipid Research, 2001
Phospholipids and sterols are known to have multiple functions in reproductive tissue of mammals. High concentrations of the cholesterol precursor desmosterol have been described in testis, epididymis, and spermatozoa of various species.
Bernhard Lindenthal, Tayseer A. Aldaghlas, Joanne K. Kelleher, Stephan M. Henkel, René Tolba, Gerhard Haidl, Klaus von Bergmann   +6 more
doaj   +1 more source

Bazedoxifene and Beyond: Identifying This SERM’s Targets and Deciphering Its Molecular Mechanisms

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Bazedoxifene (BZA), a third‐generation selective estrogen receptor modulator (SERM) approved for osteoporosis treatment, is attracting attention for drug repurposing, especially in cancer research. While designed primarily for estrogen receptors, BZA exhibits in vitro off‐target interactions that may explain novel therapeutic benefits or account for ...
Juliette Bherer, Alisson Clemenceau, Caroline Diorio, Francine Durocher, Anjali Chauhan   +4 more
wiley   +1 more source

Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models

Biomolecules
Smith–Lemli–Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC).
Zeljka Korade, Allison C. Anderson, Marta Balog, Keri A. Tallman, Ned A. Porter, Karoly Mirnics   +5 more
doaj   +1 more source

Signaling regulates activity of DHCR24, the final enzyme in cholesterol synthesis[S]

Journal of Lipid Research, 2014
The role of signaling in regulating cholesterol homeostasis is gradually becoming more widely recognized. Here, we explored how kinases and phosphorylation sites regulate the activity of the enzyme involved in the final step of cholesterol synthesis, 3β ...
Winnie Luu, Eser J. Zerenturk, Ika Kristiana, Martin P. Bucknall, Laura J. Sharpe, Andrew J. Brown   +5 more
doaj   +1 more source

Novel ABCG5 and ABCG8 Variants in Sitosterolemia: Insights Into Haemolysis, Calcium Dysregulation and Therapeutic Challenges

Human Mutation, Volume 2026, Issue 1, 2026.
Sitosterolemia is a rare autosomal recessive lipid metabolic disorder caused by mutations in ABCG5 or ABCG8, leading to pathological accumulation of dietary plant sterols. The condition is clinically heterogeneous, presenting with xanthomas, premature atherosclerosis and haematological abnormalities such as stomatocytosis, haemolytic anaemia and ...
Prashant Warang, Rashmi Dongerdiye, Pradnya Dehadrai, Prachi Kamble, Neha Samanpalliwar, Manisha Madkaikar, Chandrakala Shanmukhaiah, Prabhakar S. Kedar, Harleen Khatra   +8 more
wiley   +1 more source