Results 71 to 80 of about 2,350 (174)

Miglustat in Alzheimer's Disease Associated With Heterozygous NPC1 Mutation: Exploratory Case Series and Preliminary Findings

European Journal of Neurology, Volume 32, Issue 11, November 2025.
Three AD patients sharing the same heterozygous NPC1 mutation were orally treated with miglustat for 12 months and underwent monthly clinical and neuropsychological evaluations, brain amyloid‐PET imaging, and biochemical analyses on plasma and CSF. All three patients achieved clinical stability, showed a sustained reduction in serum oxysterol levels ...
Diego Lopergolo, Daniele Gasparini, Silvia Bianchi, Barbara Pucci, Domenico Tripodi, Valerio Leoni, Andrea Chincarini, Stelvio Sestini, Henrik Zetterberg, Nicola De Stefano, Andrea Mignarri   +10 more
wiley   +1 more source

Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL

Journal of Lipid Research, 2003
The HDL Atherosclerosis Treatment Study (HATS) demonstrated a clinical benefit in coronary artery disease patients with low HDL cholesterol (HDL-C) levels treated with simvastatin and niacin (S-N) or S-N plus antioxidants (S-N+A) compared with ...
Nirupa R. Matthan, Ann Giovanni, Ernst J. Schaefer, B.Greg Brown, Alice H. Lichtenstein   +4 more
doaj   +1 more source

Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain

Journal of Lipid Research, 2002
Cholesterol is implicated to play a role in Alzheimer disease pathology. Therefore, the concentrations of cholesterol, its precursors, and its degradation products in brain homogenates of aging wild-type and β-amyloid precursor protein transgenic mice ...
Dieter Lütjohann, Andreas Brzezinka, Esther Barth, Dorothee Abramowski, Matthias Staufenbiel, Klaus von Bergmann, Konrad Beyreuther, Gerd Multhaup, Thomas A. Bayer   +8 more
doaj   +1 more source

THE ESTIMATION OF DESMOSTEROL AND CHOLESTEROL IN PLASMA [PDF]

Heart, 1964
L G, WHITBY, R G, GOLD, E G, KITCHIN, H A, FLEMING   +3 more
openaire   +2 more sources

Feedback regulation of cholesterol biosynthesis in rhesus monkeys with variable hypercholesterolemic response to dietary cholesterol1

Journal of Lipid Research, 1981
To test the hypothesis that high-responding rhesus monkeys should have a greater degree of feedback inhibition of hepatic cholesterol biosynthesis than the low-responding monkeys because the former group absorbs a higher percentage of cholesterol than ...
A K Bhattacharyya, D A Eggen
doaj   +1 more source

The effect of hydroxychloroquine on cholesterol synthesis depends on the profile of cholesterol metabolism. A controlled clinical study

Atherosclerosis Plus
Background and aims: Hydroxychloroquine (HCQ) has a variable effect on cholesterol synthesis. To clarify this, we assessed the effect of HCQ on the cholesterol-synthesis pathway in individuals with low and high cholesterol absorption efficiency.
Piia Simonen, Lotta Ulander, Kari K. Eklund, Mikko Niemi, Janne T. Backman, Helena Gylling, Juha Sinisalo   +6 more
doaj   +1 more source

Antibacterial and Antioxidant Compounds from Root Extracts of Gloriosa superba Linn: A Combined Experimental and Computational Study

Ethiopian Journal of Science and Sustainable Development
Throughout history, medicinal plants have globally served as remedies for various ailments, and diseases. The roots of Gloriosa superba are traditionally used to treat antitumor, antimicrobial, and anti-inflammatory diseases. In this study, the roots of
Iman Mustefa, Milkyas Endale, Rajalakshmanan Eswaramoorthy   +2 more
doaj   +1 more source

Cholesterol and desmosterol dancing to the beat of a different drug [PDF]

Journal of Internal Medicine, 2017
A J, Brown, I C, Gelissen
openaire   +2 more sources

THE IN VITRO METABOLISM OF DESMOSTEROL WITH ADRENAL AND LIVER PREPARATIONS* [PDF]

Journal of Clinical Investigation, 1962
D S, GOODMAN, J, AVIGAN, H, WILSON
openaire   +2 more sources

A genome-wide association meta-analysis of cholesterol synthesis intermediates identifies three associations for lanosterol. [PDF]

EBioMedicine
Förster F, Horn K, Pott J, Delgado GE, Kleber ME, März W, Moissl-Blanke AP, Silbernagel G, Waldenberger M, Grallert H, Peters A, Gieger C, Baber R, Kirsten H, Loeffler M, Isermann B, Thiery J, Kovacs P, Tönjes A, Stumvoll M, Gylling H, Kähönen M, Lehtimäki T, Mishra PP, Raitakari O, Ceglarek U, Scholz M.   +26 more
europepmc   +1 more source