Results 21 to 30 of about 2,350 (174)

Desmosterol Deposition in Human and Experimental Atherosclerosis [PDF]

Circulation Research, 1963
The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition.
J H, HERNDON, M D, SIPERSTEIN
openaire   +2 more sources

Uneven distribution of desmosterol and docosahexaenoic acid in the heads and tails of monkey sperm1

Journal of Lipid Research, 1998
Previously we demonstrated high concentrations of desmosterol and docosahexaenoic acid (DHA, 22:6 n–
William E. Connor, Don S. Lin, D.P. Wolf, M. Alexander   +3 more
doaj   +1 more source

The Plasma Distribution of Non-cholesterol Sterol Precursors and Products of Cholesterol Synthesis and Phytosterols Depend on HDL Concentration

Frontiers in Nutrition, 2022
Non-cholesterol sterols are transported in plasma lipoproteins and are consequently important in cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors of cholesterol synthesis (NCSPCS), oxysterols, and phytosterols
Valéria Sutti Nunes, Eliton Juniro da Silva, Guilherme da Silva Ferreira, Sayonara Ivana Santos de Assis, Patrícia Miralda Cazita, Edna Regina Nakandakare, Vanessa Helena de Souza Zago, Eliana Cotta de Faria, Eder Carlos Rocha Quintão   +8 more
doaj   +1 more source

Analysis of bioactive oxysterols in newborn mouse brain by LC/MS

Journal of Lipid Research, 2012
Unesterified cholesterol is a major component of plasma membranes. In the brain of the adult, it is mostly found in myelin sheaths, where it plays a major architectural role.
Anna Meljon, Spyridon Theofilopoulos, Cedric H.L. Shackleton, Gordon L. Watson, Norman B. Javitt, Hans-Joachim Knölker, Ratni Saini, Ernest Arenas, Yuqin Wang, William J. Griffiths   +9 more
doaj   +1 more source

Biosynthesis of squalene and sterols by rat aorta

Journal of Lipid Research, 1971
The synthesis of nonsaponifiable compounds from radioactive mevalonate by segments of adult rat aorta was studied in vitro. The labeled products consisted largely of substances with the chromatographic and chemical behavior of squalene, lanosterol ...
MARIE M. DALY
doaj   +1 more source

Metoprolol Inhibits Developmental Brain Sterol Biosynthesis in Mice

Biomolecules, 2022
De novo sterol synthesis is a critical homeostatic mechanism in the brain that begins during early embryonic development and continues throughout life.
Luke B. Allen, Károly Mirnics
doaj   +1 more source

The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally[S]

Journal of Lipid Research, 2015
Cholesterol is essential to human health, and its levels are tightly regulated by a balance of synthesis, uptake, and efflux. Cholesterol synthesis requires the actions of more than twenty enzymes to reach the final product, through two alternate ...
Winnie Luu, Gene Hart-Smith, Laura J. Sharpe, Andrew J. Brown   +3 more
doaj   +1 more source

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Journal of Lipid Research, 2022
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited.
Marta Balog, Allison Anderson, Thiago C. Genaro-Mattos, Zeljka Korade, Karoly Mirnics   +4 more
doaj   +1 more source

Formal Synthesis of Squalamine from Desmosterol.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Okumura, Kazuo, Nakamura, Yutaka, Takeuchi, Seiji, Kato, Isao, Fujimoto, Yoshinori, Ikekawa, Nobuo   +5 more
openaire   +3 more sources

Desmosterol: A natural product derived from macroalgae modulates inflammatory response and oxidative stress pathways in intestinal epithelial cells

Frontiers in Immunology, 2023
The serum level of cholesterol and its biosynthetic intermediates are critical indicators to access metabolism-related disorders in humans and animals.
Huan Qu, Qiufang Zong, Ping Hu, Zhaojian Li, Haifei Wang, Haifei Wang, Shenglong Wu, Shenglong Wu, Hao-Yu Liu, Hao-Yu Liu, Wenbin Bao, Wenbin Bao, Demin Cai, Demin Cai   +13 more
doaj   +1 more source