Results 11 to 20 of about 2,350 (174)

Oxygenation of desmosterol and cholesterol in cell cultures.

Journal of Lipid Research, 1990
In order to determine whether hydration of the delta 24 bond of desmosterol contributes to the formation of the regulatory oxysterol, 25-hydroxycholesterol, [3H]desmosterol was incubated with two cultured cell lines and the labeled products were analyzed.
SE Saucier, AA Kandutsch, AK Gayen, JA Nelson, TA Spencer   +4 more
doaj   +3 more sources

Pollen sterols are highly diverse but phylogenetically conserved. [PDF]

New Phytol
Summary Phytosterols regulate cell membrane fluidity and are precursors for plant hormones and secondary metabolites in plants. Insects are auxotrophic for sterols; therefore, they have to consume phytosterols and dealkylate them to cholesterol. Some insects, including bees, which rely on dietary sources, primarily pollen, for sterols, cannot modify ...
Baker EC, Lamborn E, Quiñonez J, Karlsdottir S, Sheppard A, Moore E, Kunin WE, Wright GA, Stevenson PC.   +8 more
europepmc   +3 more sources

High cholesterol absorption efficiency enhances proatherogenic properties of low-density lipoprotein particles. [PDF]

J Intern Med
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Öörni K, Äikäs L, Ruuth M, Tigistu-Sahle F, Käkelä R, Wester I, Gylling H, Simonen P.   +7 more
europepmc   +2 more sources

Desmosterol in Human Nonalcoholic Steatohepatitis [PDF]

Hepatology, 2013
Dysregulation of the cholesterol synthesis pathway and accumulation of cholesterol in the liver are linked to the pathogenesis of nonalcoholic steatohepatitis (NASH). Therefore, we investigated the association of serum and liver levels of cholesterol precursors with NASH.
Kaminska Dorota, Gylling Helena Kristiin, Kuusisto Johanna, Pihlajamäki Jussi, Laakso Markku, Simonen Marko, Käkelä Pirjo, Kärjä Vesa Juhani, Männistö Ville, Gylling Helena, Pihlajamäki Jussi, Kuusisto Maria, Laakso Markku, Simonen Marko, Käkelä Pirjo, Venesmaa Sari, Kärjä Vesa, Männistö Ville, Gylling Helena, Gylling Helena   +19 more
openaire   +2 more sources

Desmosterol accumulation in users of amiodarone [PDF]

Journal of Internal Medicine, 2017
AbstractBackgroundAmiodarone is an effective and widely used antiarrhythmic drug with many possible adverse effects including hypercholesterolaemia and hepatotoxicity.ObjectiveOur aim was to evaluate how long‐term amiodarone treatment affects cholesterol metabolism.MethodsThe study population consisted of 56 cardiac patients, of whom 20 were on ...
Lampi A. -M., Gylling H., Lehtonen J., Kupari M., Simonen P., Stenman U. -H., Piironen V., Lampi A. -M., Gylling H., Lehtonen J., Kupari M., Simonen P., Stenman U. -H., Piironen V.   +13 more
openaire   +2 more sources

In vitro metabolomics approaches to decipher the biochemical and cellular response to genotoxic compounds. [PDF]

EFSA J
Abstract New approach methodologies (NAMs) are gaining increasing attention within the scientific community as strategies to reduce the use of animal testing. Their integration into regulatory frameworks for chemical hazard and risk assessment in food and feed would directly support the goals of the European Food Safety Authority (EFSA).
Amaro F, Siniscalchi E, Varalda GM, Azzinnari E, Pinto J, de Pinho PG, Iorio E, Marcon F.   +7 more
europepmc   +2 more sources

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The beneficial effects of LXR-pathway activation have long been appreciated, but clinical application of synthetic LXR ligands has been limited by coactivation of SREBP1c and consequent hypertriglyceridemia. Natural LXR ligands such as desmosterol do not promote hypertriglyceridemia because of coordinate down-regulation ...
Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Bonne M. Thompson, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, Christopher K. Glass   +16 more
openaire   +5 more sources

Desmosterol Accumulation in Rats with Experimental Myotonia [PDF]

Clinical Chemistry and Laboratory Medicine, 1975
Desmosterol is found in various organs of rats that show signs of myotonia in their skeletal muscle as a result of treatment with 20.25-diazacholesterol. The amount of desmosterol depends on the time of treatment, and is different in different organs and different kinds of muscle.
Seiler, D., Fiehn, W., Kuhn, E.
openaire   +3 more sources

Tissue distribution of cholesterol and 24-dehydrocholesterol during chronic triparanol therapy

Journal of Lipid Research, 1965
The tissues of five patients who died following 4–31 months of continuous oral triparanol therapy have been analyzed for sterol content by gas–liquid chromatographic techniques.
Aram V. Chobanian, William Hollander
doaj   +1 more source

Effect of triparanol on atherosclerosis and on sterol composition and concentration in serum and aorta of the chicken*

Journal of Lipid Research, 1963
The administration of triparanol resulted in an increase in serum total sterols and desmosterol in both cockerels and egg-laying pullets. In cockerels treated for 20 weeks with 25.0 mg of triparanol/kg body weight, the total serum sterol level was 106 mg/
Harry Y.C. Wong, Joel Avigan, Robert L. Raiford, Ann Butler, Hugh E. Vroman   +4 more
doaj   +1 more source