Results 11 to 20 of about 2,412 (177)

High cholesterol absorption efficiency enhances proatherogenic properties of low-density lipoprotein particles. [PDF]

J Intern Med
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Öörni K, Äikäs L, Ruuth M, Tigistu-Sahle F, Käkelä R, Wester I, Gylling H, Simonen P.   +7 more
europepmc   +2 more sources

Physiological Functions of Side-Chain-Retaining Sterols in the Brain and Their Roles in Neurodegenerative Diseases [PDF]

Metabolites
Although the brain comprises only 2% of total body weight, it contains approximately 23% of the total cholesterol of the body. In the brain, cholesterol plays a critical role as a structural component of cell membranes and myelin sheaths.
Yoshimitsu Kiriyama, Akira Nakatsuma, Hiroshi Tokumaru, Hisayo Sadamoto, Hiromi Nochi   +4 more
doaj   +2 more sources

In vitro metabolomics approaches to decipher the biochemical and cellular response to genotoxic compounds. [PDF]

EFSA J
Abstract New approach methodologies (NAMs) are gaining increasing attention within the scientific community as strategies to reduce the use of animal testing. Their integration into regulatory frameworks for chemical hazard and risk assessment in food and feed would directly support the goals of the European Food Safety Authority (EFSA).
Amaro F, Siniscalchi E, Varalda GM, Azzinnari E, Pinto J, de Pinho PG, Iorio E, Marcon F.   +7 more
europepmc   +2 more sources

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance The beneficial effects of LXR-pathway activation have long been appreciated, but clinical application of synthetic LXR ligands has been limited by coactivation of SREBP1c and consequent hypertriglyceridemia. Natural LXR ligands such as desmosterol do not promote hypertriglyceridemia because of coordinate down-regulation ...
Evan D. Muse, Shan Yu, Chantle R. Edillor, Jenhan Tao, Nathanael J. Spann, Ty D. Troutman, Jason S. Seidman, Adam Henke, Jason T. Roland, Katherine A. Ozeki, Bonne M. Thompson, Jeffrey G. McDonald, John Bahadorani, Sotirios Tsimikas, Tamar R. Grossman, Matthew S. Tremblay, Christopher K. Glass   +16 more
openaire   +5 more sources

Adipose Tissue-Derived Mesenchymal Stem Cells Alter Metabolites of Brain Cholesterol Homeostasis in An Alzheimer’s Model [PDF]

Cell Journal, 2023
Objective: Disruption of cholesterol homeostasis in Alzheimer’s disease (AD) plays a crucial role in diseasepathogenesis, making it a potential therapeutic target.
Mehrnaz Karimi Darabi, Zahra Nazeri, Arash Rafeeinia, Seyedeh Pardis Pezeshki, Alireza Kheirollah, Yaghoob Farbood, Maryam Adelipour, Shirin Azizidoost, Maryam Cheraghzadeh   +8 more
doaj   +1 more source

Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies

Brazilian Journal of Medical and Biological Research, 2012
Effective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial.
S.H. Kasmas, M.C. Izar, C.N. França, S.C. Ramos, F.T. Moreira, T. Helfenstein, R.A. Moreno, N.C. Borges, A.M. Figueiredo-Neto, F.A. Fonseca   +9 more
doaj   +3 more sources

Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology

Journal of Lipid Research, 2012
We performed unbiased analysis of steroid-related compounds to identify novel Alzheimer's disease (AD) plasma biomarkers using liquid chromatography-atmospheric pressure chemical ionization-mass spectroscopy.
Yoshiaki Sato, Ikumi Suzuki, Tatsuji Nakamura, Francois Bernier, Ken Aoshima, Yoshiya Oda   +5 more
doaj   +1 more source

Desmosterol Accumulation in Rats with Experimental Myotonia [PDF]

Clinical Chemistry and Laboratory Medicine, 1975
Desmosterol is found in various organs of rats that show signs of myotonia in their skeletal muscle as a result of treatment with 20.25-diazacholesterol. The amount of desmosterol depends on the time of treatment, and is different in different organs and different kinds of muscle.
Seiler, D., Fiehn, W., Kuhn, E.
openaire   +3 more sources

Tissue distribution of cholesterol and 24-dehydrocholesterol during chronic triparanol therapy

Journal of Lipid Research, 1965
The tissues of five patients who died following 4–31 months of continuous oral triparanol therapy have been analyzed for sterol content by gas–liquid chromatographic techniques.
Aram V. Chobanian, William Hollander
doaj   +1 more source

Desmosterol Deposition in Human and Experimental Atherosclerosis [PDF]

Circulation Research, 1963
The role of desmosterol in the production of atherosclerotic plaques has been studied. By means of gas chromatographic analysis, it has been possible for the first time to show that in patients treated with triparanol, even for short periods of time, desmosterol does contribute to the sterol deposition.
J H, HERNDON, M D, SIPERSTEIN
openaire   +2 more sources