Results 81 to 90 of about 320 (132)

Synthesis of 7-dehydrocholesterol acetate

Chemistry of Natural Compounds, 1973
It has been shown that 7-oxocholesterol acetate (III) can easily be converted into 7-dehydrocholesterol acetate by the Bamford-Stevens reaction. The yield of desired product amounts to 79% calculated on the (III) or 63% calculated on the cholesterol acetate.
E. V. Yablonskaya, M. G. Segal
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Photochemical transformations of 7-dehydrocholesterol

Russian Journal of Applied Chemistry, 2009
Photochemical transformations of 7-dehydrocholesterol were performed with a two-lamp experimental circulation installation equipped with a ferrioxalate actinometer and were monitored by UV spectroscopy and high-performance liquid chromatography. The quantum yields of the overall conversion of 7-dehydrocholesterol at wavelengths of 254, 313, and 365 nm ...
Z. L. Grigoryan, A. I. Martiryan, L. A. Nersesyan, Sh. A. Markaryan   +3 more
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The preparation of radioactive 7-dehydrocholesterol

Steroids, 1963
The preparation of radioactive 7-dehydrocholesterol (5,7-cholestadien-3 BETA -ol) by procedures that utilize milligram quantities of cholesterol as starting material is described. The isocaproate adaptation of the allylic bromination of cholesterol with N-bromosuccinimide followed by dehydrobromination was employed and found to be amenable to a scale ...
B.D. Kulkarni, G. Blondin, W.R. Nes
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7-Dehydrocholesterol is an endogenous suppressor of ferroptosis

Nature
Ferroptosis is a form of cell death that has received considerable attention not only as a means to eradicate defined tumour entities but also because it provides unforeseen insights into the metabolic adaptation that tumours exploit to counteract phospholipid oxidation1,2.
Florencio Porto Freitas, Hamed Alborzinia, Ancély Ferreira dos Santos, Palina Nepachalovich, Lohans Pedrera, Omkar Zilka, Alex Inague, Corinna Klein, Nesrine Aroua, Kamini Kaushal, Bettina Kast, Svenja M. Lorenz, Viktoria Kunz, Helene Nehring, Thamara N. Xavier da Silva, Zhiyi Chen, Sena Atici, Sebastian G. Doll, Emily L. Schaefer, Ifedapo Ekpo, Werner Schmitz, Aline Horling, Peter Imming, Sayuri Miyamoto, Ann M. Wehman, Thiago C. Genaro-Mattos, Karoly Mirnics, Lokender Kumar, Judith Klein-Seetharaman, Svenja Meierjohann, Isabel Weigand, Matthias Kroiss, Georg W. Bornkamm, Fernando Gomes, Luis Eduardo Soares Netto, Manjima B. Sathian, David B. Konrad, Douglas F. Covey, Bernhard Michalke, Kurt Bommert, Ralf C. Bargou, Ana Garcia-Saez, Derek A. Pratt, Maria Fedorova, Andreas Trumpp, Marcus Conrad, José Pedro Friedmann Angeli   +46 more
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Photometabolism of 7-dehydrocholesterol to previtamin D3 in skin

Biochemical and Biophysical Research Communications, 1977
Abstract The photometabolism of [3α-3H]-7-dehydrocholesterol in skin was studied in groups of rats exposed to ultraviolet irradiation. The major photolytic product was identified as previtamin D3 by its identical migration with authentic previtamin D3 on high-pressure liquid chromatography.
M F, Holick, J E, Frommer, S C, McNeill, N M, Richtand, J W, Henley, J T, Potts   +5 more
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7-Dehydrocholesterol dictates ferroptosis sensitivity

Nature
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid peroxidation, has been implicated in multiple diseases, including cancer1-3, degenerative disorders4 and organ ischaemia-reperfusion injury (IRI)5,6. Here, using genome-wide CRISPR-Cas9 screening, we identified that the enzymes involved in distal cholesterol ...
Yaxu Li, Qiao Ran, Qiuhui Duan, Jiali Jin, Yanjin Wang, Lei Yu, Chaojie Wang, Zhenyun Zhu, Xin Chen, Linjun Weng, Zan Li, Jia Wang, Qi Wu, Hui Wang, Hongling Tian, Sihui Song, Zezhi Shan, Qiwei Zhai, Huanlong Qin, Shili Chen, Lan Fang, Huiyong Yin, Hu Zhou, Xuejun Jiang, Ping Wang   +24 more
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HPLC analysis of desmosterol, 7‐dehydrocholesterol, and cholesterol

Lipids, 1989
AbstractA simple and sensitive method to analyzed mixtures of desmosterol, 7‐dehydrocholesterol and cholesterol is described. The method involves the oxidative conversion of the sterols with cholesterol oxidase, followed by high performance liquid chromatographic (HPLC) analysis.
E H, Goh, S M, Colles, K D, Otte
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The effects of 7-dehydrocholesterol on the structural properties of membranes

Physical Biology, 2011
Smith-Lemli-Opitz syndrome, a congenital and developmental malformation disease, is typified by abnormal accumulation of 7-dehydrocholesterol (7DHC), the immediate precursor of cholesterol (CHOL), and depletion thereof. Knowledge of the effect of 7DHC on the biological membrane is, however, still fragmentary.
Yingzhe, Liu, Christophe, Chipot, Xueguang, Shao, Wensheng, Cai   +3 more
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Identifying Molecular Fragments That Drive 7-Dehydrocholesterol Elevation

ACS Pharmacology & Translational Science, 2021
Medications having the unwanted side effect of inhibiting 7-dehydrocholesterol reductase (DHCR7), one of the last enzymes in the cholesterol biosynthesis pathway, account for about 300 million yearly prescriptions in the United States. Many of these drugs are currently prescribed to pregnant women.
Dario Ghersi, Thiago C. Genaro-Mattos
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Light‐Induced Activation of 7‐Dehydrocholesterol

Angewandte Chemie International Edition in English, 1982
AbstractThe complete manuscript of this communication appears in: Angew. Chem. Suppl. 1982, 846.
Karlheinz Schmitt‐Rau, Manfred Wilk
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