Results 71 to 80 of about 320 (132)

Long-term effects of sterol depletion in C. elegans

Journal of Lipid Research, 2004
Three major long-term effects of sterol deprivation in Caenorhabditis elegans are described. 1) The life expectancy of sterol-deprived wild-type animals is decreased by more than 40%. Similar decreases are found in animals carrying mutations in the daf-9,
Mark Merris, Jessica Kraeft, G.S. Tint, John Lenard   +3 more
doaj   +1 more source

A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome[S]

Journal of Lipid Research, 2014
We describe a highly sensitive method for the detection of 7-dehydrocholesterol (7-DHC), the biosynthetic precursor of cholesterol, based on its reactivity with 4-phenyl-1,2,4-triazoline-3,5-dione (PTAD) in a Diels-Alder cycloaddition reaction.
Wei Liu, Libin Xu, Connor Lamberson, Dorothea Haas, Zeljka Korade, Ned A. Porter   +5 more
doaj   +1 more source

Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis

Nature Communications
Recent evidence indicates ferroptosis is implicated in the pathophysiology of various liver diseases; however, the organ-specific regulation mechanism is poorly understood.
Naoya Yamada, Tadayoshi Karasawa, Junya Ito, Daisuke Yamamuro, Kazushi Morimoto, Toshitaka Nakamura, Takanori Komada, Chintogtokh Baatarjav, Yuma Saimoto, Yuka Jinnouchi, Kazuhisa Watanabe, Kouichi Miura, Naoya Yahagi, Kiyotaka Nakagawa, Takayoshi Matsumura, Ken-ichi Yamada, Shun Ishibashi, Naohiro Sata, Marcus Conrad, Masafumi Takahashi   +19 more
doaj   +1 more source

Synthesis of 7-dehydrocholesterol through hexacarbonyl molybdenum catalyzed elimination reaction

Bulletin of the Chemical Society of Ethiopia, 2011
The efficiency of hexacarbonyl molybdenum catalyzed elimination reaction of the allylic acetates has been improved by the presence of O,N-bis(trimethylsilyl) acetamide in the reaction medium.
Faiz ur Rahman, Tian Wei Tan
doaj  

Cholic acid increases plasma cholesterol in Smith-Lemli-Opitz syndrome: A pilot study

Molecular Genetics and Metabolism Reports
Background: Smith-Lemli-Opitz syndrome (SLOS) is an inherited disorder of cholesterol biosynthesis associated with congenital malformations, growth delay, intellectual disability and behavior problems.
Ellen R. Elias, Lucas E. Orth, Amy Li, Libin Xu, Sara M. Jones, William B. Rizzo   +5 more
doaj   +1 more source

Sterol metabolism. 4. The absorption of 7-dehydrocholesterol in the rat [PDF]

Biochemical Journal, 1959
J, GLOVER, D W, STAINER
openaire   +2 more sources

Studies on Cholestapolyenes. I. : Syntheses of Bicholestatriene A and 7-Dehydrocholesterol.

Pharmaceutical Bulletin, 1953
Arima, Ko, Hayatsu, Ryoichi
openaire   +3 more sources

7-Dehydrocholesterol–Mediated Regulation of Ferroptosis in the Liver

Oleoscience
Naoya YAMADA, Tadayoshi KARASAWA, Masafumi TAKAHASHI   +2 more
openaire   +1 more source

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Selective ability of rat 7-Dehydrocholesterol reductase (DHCR7) to act on some 7-Dehydrocholesterol metabolites but not on lumisterol metabolites

Journal of Steroid Biochemistry and Molecular Biology, 2021
7-Dehydrocholesterol reductase (DHCR7) catalyses the final step of cholesterol biosynthesis in the Kandutsch-Russel pathway, the reduction of 7-dehydrocholesterol (7DHC) to cholesterol. 7DHC can be acted on by a range of other enzymes including CYP27A1 and CYP11A1, as well as by UVB radiation, producing a number of derivatives including hydroxy ...
, Robert Tuckey, Edith Tang
exaly   +3 more sources

Skin content of 7-dehydrocholesterol in patients with malabsorption

Nutrition, 1997
The mechanism for the development of vitamin D deficiency in patients with malabsorption remains unclear. We wished to examine the hypothesis that one factor was a reduced skin content of 7-dehydrocholesterol, the precursor for the formation of vitamin D in the presence of ultraviolet radiation.
C R Pennington
exaly   +3 more sources