Results 21 to 30 of about 320 (132)

Oxysterols in the circulation of patients with the Smith-Lemli-Opitz syndrome: abnormal levels of 24S- and 27-hydroxycholesterol

Journal of Lipid Research, 2001
Infants with the cholesterol synthesis defect Smith-Lemli-Opitz syndrome (SLO) have reduced activity of the enzyme 7-dehydrocholesterol-7-reductase and accumulate 7-dehydrocholesterol, with the highest concentration in the brain.
Ingemar Björkhem, Lena Starck, Ulla Andersson, Dieter Lütjohann, Sara von Bahr, Irina Pikuleva, Amir Babiker, Ulf Diczfalusy   +7 more
doaj   +1 more source

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Journal of Lipid Research, 2022
Polypharmacy, or the simultaneous use of multiple drugs to treat a single patient, is a common practice in psychiatry. Unfortunately, data on the health effects of commonly used combinations of medications are very limited.
Marta Balog, Allison Anderson, Thiago C. Genaro-Mattos, Zeljka Korade, Karoly Mirnics   +4 more
doaj   +1 more source

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production

Biomolecules, 2021
24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj   +1 more source

Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol Δ7-reductase, on serum and tissue lipids in the rat

Journal of Lipid Research, 1968
The effect of long-term administration of AY-9944, a specific inhibitor of cholesterol biosynthesis, was examined in rats maintained on diets with low and high cholesterol and fat content.
D. Dvornik, P. Hill
doaj   +1 more source

Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression

Journal of Lipid Research, 2005
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes.
Carlos Fernández, Miguel Martín, Diego Gómez-Coronado, Miguel A. Lasunción   +3 more
doaj   +1 more source

Sterol balance in the Smith-Lemli-Opitz syndrome: reduction in whole body cholesterol synthesis and normal bile acid production

Journal of Lipid Research, 2000
The Smith-Lemli-Opitz syndrome (SLOS) is a multiple malformation/mental retardation syndrome caused by a deficiency of the enzyme 7-dehydrocholesterol Δ7-reductase.
Robert D. Steiner, Leesa M. Linck, Donna P. Flavell, Don S. Lin, William E. Connor   +4 more
doaj   +1 more source

Sterols in blood of normal and Smith-Lemli-Opitz subjects

Journal of Lipid Research, 2001
Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of noncholesterol sterols, such as 7- and 8-dehydrocholesterol.
Benfang Ruan, William K. Wilson, Jihai Pang, Nicolas Gerst, Frederick D. Pinkerton, James Tsai, Richard I. Kelley, Frank G. Whitby, Dianna M. Milewicz, James Garbern, George J. Schroepfer, Jr.   +10 more
doaj   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Biosynthesis of squalene and sterols by rat aorta

Journal of Lipid Research, 1971
The synthesis of nonsaponifiable compounds from radioactive mevalonate by segments of adult rat aorta was studied in vitro. The labeled products consisted largely of substances with the chromatographic and chemical behavior of squalene, lanosterol ...
MARIE M. DALY
doaj   +1 more source

Desmosterol and 7-dehydrocholesterol concentrations in post mortem brains of depressed people: The role of trazodone

Translational Psychiatry, 2022
Major depressive disorder (MDD) is a common, disabling, and heterogeneous condition that responds unpredictably to current treatments. We previously showed an association between depressive symptoms and plasma concentrations of two cholesterol precursors,
Basar Cenik, Jayme M. Palka, Bonne M. Thompson, Jeffrey G. McDonald, Carol A. Tamminga, Can Cenik, E. Sherwood Brown   +6 more
doaj   +1 more source