Results 181 to 190 of about 23,617 (228)

Reduced 7-Dehydrocholesterol Reductase Activity Impairs the Glutathione Redox Status in a Neurological Cell Model

Free Radical Biology and Medicine, 2016
7-Dehydrocholesterol reductase (DHCR7) serves as the penultimate enzyme in the Kandutsch-Russel pathway of cholesterol synthesis. When the function of DHCR7 is compromised its primary substrate, 7-dehydrocholesterol (7DHC), accumulates. The accumulation of 7DHC can be detrimental to many biological processes, as observed in the metabolic disorder Smith-
Phillip A Wages, Zeljka Korade, Ned A Porter   +2 more
openaire   +2 more sources

7-Dehydrocholesterol Reductase Deficiency

Encyclopedia of Autism Spectrum Disorders, 2021
openaire   +2 more sources

A novel mutation of the human 7-dehydrocholesterol reductase gene reduces enzyme activity in patients with holoprosencephaly

Biochemical and Biophysical Research Communications, 2004
Defects in cholesterol biosynthesis genes are recognized as a leading cause for holoprosencephaly (HPE). Previous reports suggest that mutations of human 7-dehydrocholesterol reductase (Dhcr7), which catalyzes the final step of cholesterol biosynthesis, may cause HPE [Clin. Genet. 53 (1998) 155]. To determine whether Dhcr7 mutations are involved in HPE
Yhong-Hee, Shim, Soo-Han, Bae, Jai-Hyun, Kim, Kyu-Rae, Kim, Chong Jai, Kim, Young-Ki, Paik   +5 more
openaire   +3 more sources

Characterization and potential function of 7-dehydrocholesterol reductase (dhcr7) and lathosterol 5-desaturase (sc5d) in Cynoglossus semilaevis sexual size dimorphism.

Gene, 2022
The typical sexual size dimorphism (SSD) phenomenon of Chinese tongue sole (Cynoglossus semilaevis) seriously restricts the sustainable development of the fishing industry.
Jialin Wang, Rui Shi, Qiang Yang, Zhangfan Chen, Jiacheng Wang, Zhihong Gong, Songlin Chen, Na Wang   +7 more
semanticscholar   +1 more source

Transcriptomic investigation of the biochemical function of 7-dehydrocholesterol reductase 1 from the traditional Chinese medicinal plant Anemarrhena asphodeloides Bunge.

Phytochemistry, 2021
Anemarrhena asphodeloides Bunge (Liliaceae) is an important Traditional Chinese Medicine herb, which contains up to 6 % total steroidal saponins (timosaponins) and has multiple pharmacological properties. However, the timosaponin biosynthetic pathway has
Yunpeng Wang, Wenbo Xiong, YiDu Chen, Min Zhu, Jincai Liang, Yu Li, Jia Huang, Liufang Huang, Zhongqiu Liu, Aijia Ji, Lixin Duan   +10 more
semanticscholar   +1 more source

Effects of Tween 80 on liver microsomal 7-dehydrocholesterol reductase

Biochemical and Biophysical Research Communications, 1978
Abstract Enzymatic conversion of 7-dehydrocholesterol to cholesterol by liver microsomes was increased by addition of Tween 80. This increase was proportional to Tween 80 concentration, and reached its maximum of 250% of baseline activity after addition of 300 μg/ml of Tween 80.
M V, Srikantaiah, S, Assef, R J, Morin
openaire   +2 more sources

m6A-Mediated Induction of 7-Dehydrocholesterol Reductase Stimulates Cholesterol Synthesis and cAMP Signaling to Promote Bladder Cancer Metastasis.

Cancer Research
Dysregulation of cholesterol homeostasis occurs in multiple types of tumors and promotes cancer progression. Investigating the specific processes that induce abnormal cholesterol metabolism could identify therapeutic targets to improve cancer treatment ...
Youmiao Zeng, Yongbo Luo, Keyuan Zhao, Sheng Liu, Kaiwen Wu, Yudong Wu, Kaixuan Du, Wenbang Pan, Yiheng Dai, Yuanhao Liu, Mengda Ren, Fengyan Tian, Lijie Zhou, Chaohui Gu   +13 more
semanticscholar   +1 more source

7-Dehydrocholesterol Reductase Activates the Hedgehog Pathway by Regulating Cholesterol to Promote the Development of Triple-Negative Breast Cancer.

Current Cancer Drug Targets
BACKGROUND Cholesterol has been shown to be a potential risk factor for the occurrence and progression of breast cancer. This study aimed to investigate the regulation of DHCR7 in cholesterol synthesis and its role in Hedgehog (Hh) signaling pathway ...
Jianwei Sun, S. Qiu, Yu Sun, Yuanyuan Liu, Jinyu Yang, Xin Chen, Dinghui Wu, Li Li   +7 more
semanticscholar   +1 more source

7-dehydrocholesterol reductase inhibitors control Leishmania spp. in human macrophages.

Experimental parasitology
Leishmaniasis, caused by Leishmania spp., is a neglected parasitic disease with a broad clinical spectrum, whose treatments are toxic and present failures and resistance.
Carlos Henrique da Silva Mota, Ana Marília Viana Utim, W. de Paula, G. D. de Oliveira, Ana Torres, F. Ribeiro-Dias, R. S. Gomes   +6 more
semanticscholar   +1 more source

DD–RT–PCR identifies 7-dehydrocholesterol reductase as a key marker of early Leydig cell steroidogenesis

Molecular and Cellular Endocrinology, 2004
Postnatal Leydig cell development in rat involves an initial phase of proliferation of progenitor Leydig cells (PLCs) and subsequent differentiation of these cells into immature Leydig cells (ILCs) and adult Leydig cells (ALCs). With an objective to identify the molecular changes associated with Leydig cell differentiation, the mRNA population in PLCs ...
Anbalagan, M, Yashwanth, R, Rao, Jagannadha A   +2 more
openaire   +3 more sources