Results 11 to 20 of about 3,608 (158)

Targeting Brain Cholesterol Homeostasis in Alzheimer's Disease: Mechanisms and Therapeutic Perspectives. [PDF]

J Neurochem
Brain cholesterol homeostasis is tightly regulated and largely independent of peripheral cholesterol. This review proposes a unifying framework in which aging, sex, and related biological stressors, including hypercholesterolemia, neurodegeneration, inflammation, and oxidative stress, converge to disrupt cholesterol homeostasis in the brain ...
Ruthirakuhan M, Taha AY, Swardfager W.
europepmc   +2 more sources

Methylation of CpG Islands in the Rat 7-dehydrocholesterol Reductase Promoter Suppresses Transcriptional Activation

Molecules and Cells, 2005
In mammals, 7-dehydrocholesterol reductase (Dhcr7) is the terminal enzyme in cholesterol biosynthesis. We previously reported that the Dhcr7 proximal promoter (-179 to +1), which contains CpG islands, is responsible for sterol-mediated expression of the rat gene.
Yhong-Hee Shim
exaly   +3 more sources

[Influence of 7-dehydrocholesterol reductase gene silencing on the fusion of mouse palatal shelves]. [PDF]

Hua Xi Kou Qiang Yi Xue Za Zhi, 2015
RNA interference was applied to knockdown the Dhcr7 gene in mouse embryonic palatal shelves to facilitate understanding of the function of Dhcr7 gene variants in the fusion of palatal shelves.The pAdTrack-CMV-siDhcr7 was constructed using the specific siRNA sequence of Dhcr7 from C57BL/6J mouse.
Wenlin X, Cuizhu Z, Yan S, Yaoxiang X, Lingfa X.   +4 more
europepmc   +3 more sources

Mapping molluscan endocrinology: a systematic and critical appraisal. [PDF]

Biol Rev Camb Philos Soc
ABSTRACT Historically, a vertebrate‐centric paradigm has framed our interpretation of molluscan endocrinology, with considerable research focusing on vertebrate‐type steroid hormones (e.g. oestrogens, testosterone). However, contradictory evidence on the occurrence of vertebrate‐type steroid hormones in molluscan tissues, and a lack of the specific ...
Panagiotidis K, Miller TH, Martin OV, Baynes A.   +3 more
europepmc   +2 more sources

Downmodulation of cholesterol biosynthetic network governs activation of the innate immune response to Japanese encephalitis virus infection [PDF]

Journal of Virology
Viruses remodel metabolic processes and utilize host lipids for different stages of their life cycle. Our earlier studies have shown that the flavivirus Japanese encephalitis virus (JEV) downmodulates several key proteins involved in sterol and lipid ...
Sakshi Khera, Kiran Bala Sharma, Yashwant Kumar, Manjula Kalia   +3 more
doaj   +2 more sources

Hydroxyzine Effects on Post-Lanosterol Biosynthesis in Smith–Lemli–Opitz Syndrome (SLOS) Models [PDF]

Biomolecules
Smith–Lemli–Opitz syndrome (SLOS) is a developmental disability arising from bi-allelic pathogenic variants in the 7-dehydrocholestrol reductase (DHCR7) enzyme and the accumulation of 7-dehydrocholesterol (7-DHC).
Zeljka Korade, Allison C. Anderson, Marta Balog, Keri A. Tallman, Ned A. Porter, Karoly Mirnics   +5 more
doaj   +2 more sources

Use of cholic acid in Smith-Lemli-Opitz syndrome (SLOS): real-world patient outcomes [PDF]

Orphanet Journal of Rare Diseases
Background Smith-Lemli-Opitz Syndrome (SLOS) is an autosomal recessive disorder of cholesterol biosynthesis caused by biallelic pathogenic variants in DHCR7, which encodes the enzyme 7-dehydrocholesterol reductase (DHCR7).
Edwin Ferren, Paul R. Hillman, Amy Kritzer, Joseph Ray, Alvaro Serrano, Hope Northrup, Paige Roberts, Rana Dutta, Tiziano Pramparo, Pamela Vig, Robert D. Steiner   +10 more
doaj   +2 more sources

Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice

Biomolecules, 2022
Polypharmacy is commonly used to treat psychiatric disorders. These combinations often include drugs with sterol biosynthesis inhibiting side effects, including the antipsychotic aripiprazole (ARI), and antidepressant trazodone (TRZ).
Marta Balog, Allison C Anderson, Marija Heffer, Zeljka Korade, Karoly Mirnics   +4 more
doaj   +1 more source

Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection [PDF]

Immunity, 2020
Recent work suggests that cholesterol metabolism impacts innate immune responses against infection. However, the key enzymes or the natural products and mechanisms involved are not well elucidated. Here, we have shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression.
Jun, Xiao, Weiyun, Li, Xin, Zheng, Linlin, Qi, Hui, Wang, Chi, Zhang, Xiaopeng, Wan, Yuxiao, Zheng, Ruiyue, Zhong, Xin, Zhou, Yao, Lu, Zhiqi, Li, Ying, Qiu, Chang, Liu, Fang, Zhang, Yanbo, Zhang, Xiaoyan, Xu, Zhongzhou, Yang, Hualan, Chen, Qiwei, Zhai, Bin, Wei, Hongyan, Wang   +21 more
openaire   +2 more sources

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production

Biomolecules, 2021
24-Methylene-cholesterol is a necessary substrate for the biosynthesis of physalin and withanolide, which show promising anticancer activities. It is difficult and costly to prepare 24-methylene-cholesterol via total chemical synthesis. In this study, we
Jiao Yang, Changfu Li, Yansheng Zhang
doaj   +1 more source