Results 191 to 200 of about 23,617 (228)
Some of the next articles are maybe not open access.
Naunyn-Schmiedeberg's Archives of Pharmacology, 1996
RPR 101821 (trans-2-[4-(benzoxazol-2-yl)-phenylmethoxy] amino cyclohexane hydrochloride) is a potent cholesterol-lowering agent in rodents and marmoset. The compound inhibited rat liver microsomal squalene synthase (IC50 = 1 nM) and 7-dehydrocholesterol (7DHC) reductase (IC50 = 1 microM; Lewis et al. 1995).
D, Amin +7 more
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RPR 101821 (trans-2-[4-(benzoxazol-2-yl)-phenylmethoxy] amino cyclohexane hydrochloride) is a potent cholesterol-lowering agent in rodents and marmoset. The compound inhibited rat liver microsomal squalene synthase (IC50 = 1 nM) and 7-dehydrocholesterol (7DHC) reductase (IC50 = 1 microM; Lewis et al. 1995).
D, Amin +7 more
openaire +2 more sources
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
Abstract 1. 1. The reduction of 7-dehydrocholesterol in cell-free rat-liver homogenates has been studied. The Michaelis constant (Km) was calculated from 11 experiments to be 1.14 · 10−3 with standard error ± 0.33 · 10−3. 2. 2. Three hypocholesterolemic agents inhibited 7-dehydrocholesterol conversion by liver homogenate.
R, Niemiro, R, Fumagalli
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Abstract 1. 1. The reduction of 7-dehydrocholesterol in cell-free rat-liver homogenates has been studied. The Michaelis constant (Km) was calculated from 11 experiments to be 1.14 · 10−3 with standard error ± 0.33 · 10−3. 2. 2. Three hypocholesterolemic agents inhibited 7-dehydrocholesterol conversion by liver homogenate.
R, Niemiro, R, Fumagalli
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Steroids, 1999
Smith-Lemli-Opitz syndrome (SLOS) is a malformation syndrome associated with 7-dehydrocholesterol (7DHC) 7-reductase deficiency. Although SLOS can be detected in an affected fetus before midpregnancy by measurement of 7DHC levels in amniotic fluid or chorionic villus cells, a noninvasive, more routine method is needed.
C H, Shackleton +3 more
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Smith-Lemli-Opitz syndrome (SLOS) is a malformation syndrome associated with 7-dehydrocholesterol (7DHC) 7-reductase deficiency. Although SLOS can be detected in an affected fetus before midpregnancy by measurement of 7DHC levels in amniotic fluid or chorionic villus cells, a noninvasive, more routine method is needed.
C H, Shackleton +3 more
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Pathway Refactoring for Efficient 7-Dehydrocholesterol Production in Saccharomyces cerevisiae.
ACS Synthetic Biology7-Dehydrocholesterol (7-DHC) is a subcutaneous sterol and a precursor to various active vitamin D3. Here, a Saccharomyces cerevisiae strain equipped with the de novo biosynthetic pathway for 7-DHC was constructed.
Yuchen Han +8 more
semanticscholar +1 more source
7‐Dehydrocholesterol reductase activity in developing rat brain
Journal of Neurochemistry, 1973N L, Banik, A N, Davison
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Journal of Agricultural and Food Chemistry
7-Dehydrocholesterol (7-DHC), a direct precursor of vitamin D3, has attracted increasing attention in microbial fermentation recently. In this study, 7-DHC biosynthesis in diploid Saccharomyces cerevisiae with robust ergosterol production was achieved by
Ziqi Ye +7 more
semanticscholar +1 more source
7-Dehydrocholesterol (7-DHC), a direct precursor of vitamin D3, has attracted increasing attention in microbial fermentation recently. In this study, 7-DHC biosynthesis in diploid Saccharomyces cerevisiae with robust ergosterol production was achieved by
Ziqi Ye +7 more
semanticscholar +1 more source
Tetrahydroisoquinoline alkaloid derivatives Inhibit 7-Dehydrocholesterol reductase
Planta Medica, 2012A Horling +3 more
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