Results 81 to 90 of about 239 (110)

Derivatives of the Lignan 7′-Hydroxymatairesinol with Antioxidant Properties and Enhanced Lipophilicity

Journal of Natural Products, 2017
The lignan 7'-hydroxymatairesinol (1), extracted from the knotwoods of fir (Abies alba), spruce (Picea abies), and Douglas fir (Pseudotsuga menziesii), exhibited unexpected reactivity when esterification reactions were attempted on the hydroxy group at position C-7'.
Moraux, Thomas, Dumarçay, Stéphane, Gérardin, Philippe, Gérardin-Charbonnier, Christine   +3 more
openaire   +2 more sources

Systematic conformational search analysis of the SRR and RRR epimers of 7‐hydroxymatairesinol

Journal of Physical Organic Chemistry, 2009
AbstractAn extensive and systematic conformational search was performed on the two epimers of the natural lignan 7‐hydroxymatairesinol (HMR), by means of a home‐made Systematic Conformational Search Analysis (SCSA) code, designed to select more and more stable conformers through sequential geometry optimization of trial structures at increasing levels ...
Li Manni, G, BARONE, Giampaolo, DUCA, Dario, Dmitry Y.u. Murzin   +3 more
openaire   +2 more sources

α,β-Dibenzyl-γ-butyrolactone lignan alcohols: total synthesis of (±)-7′-hydroxyenterolactone, (±)-7′-hydroxymatairesinol and (±)-8-hydroxyenterolactone

Steroids, 2001
Two trans-alpha,beta-dibenzyl-gamma-butyrolactone lignans carrying a hydroxyl group at the beta-benzylic carbon atom and a alpha-hydroxy alpha,beta-dibenzyl-gamma-butyrolactone lignan were synthesized in racemic form using the tandem conjugate addition reaction to construct the basic lignan skeleton.
T H, Mäkelä, S A, Kaltia, K T, Wähälä, T A, Hase   +3 more
openaire   +2 more sources

Liquid chromatographic–tandem mass spectrometric method for the plant lignan 7-hydroxymatairesinol and its potential metabolites in human plasma

Journal of Chromatography B, 2003
A HPLC-MS-MS method was developed for the determination of the plant lignan 7-hydroxymatairesinol and its potential metabolites matairesinol, oxomatairesinol, alpha-conidendrin, 7-hydroxyenterolactone, enterodiol, and enterolactone in human plasma. The method included sample cleanup by solid-phase extraction (SPE) and analysis using a PE Sciex API3000 ...
Annika, Smeds, Kristo, Hakala
openaire   +2 more sources

Immunomodulatory activity of the lignan 7-hydroxymatairesinol potassium acetate (HMR/lignan™) extracted from the heartwood of Norway spruce (Picea abies)

International Immunopharmacology, 2010
The pharmacological profile of the lignan 7-hydroxymatairesinol (HMR/lignan, HMR) includes chemopreventive effects, antioxidant properties, and mild proestrogenic activity. The present study was devised to investigate the effects of HMR on THP-1 cells, an established model of human monocytes, and on human polymorphonuclear leukocytes (PMNs).
COSENTINO, MARCO, MARINO, FRANCA, MAIO, RAMONA CONSUELO, Marco Gioacchino Delle Canne, Marcello Luzzani, Silvano Paracchini, LECCHINI, SERGIO   +6 more
openaire   +3 more sources

Biological and clinical significance of 7-hydroxymatairesinol: from theory to practice

Voprosy ginekologii, akušerstva i perinatologii
Among all the properties of 7-hydroxymatairesinol (7-HMR), the least studied are antitumor ones, including against the background of fibrocystic mastopathy (FCM). Objective. To study the effects of 7-HMR on the growth rate of the tumor node in outbred female mice with a standard model of spontaneous breast cancer (BC; Ehrlich carcinoma, EC), as well as
A.N. Rubashkina, O.A. Gromova, I.Yu. Torshin, N.V. Kerimkulova   +3 more
openaire   +1 more source

Enhanced extraction and biological activity of 7-hydroxymatairesinol obtained from Norway spruce knots using aqueous solutions of ionic liquids

Green Chemistry, 2017
Biocompatible aqueous solutions of ILs rich in 7-hydroxymatairesinol (HMR) can be safely used in cosmetic and nutraceutical applications.
Ana M. Ferreira, Eduarda S. Morais, Ana Cláudia Leite, Aminou Mohamadou, Bjarne Holmbom, Thomas Holmbom, Bruno M. Neves, João A. P. Coutinho, Mara G. Freire, Armando J. D. Silvestre   +9 more
openaire   +2 more sources

Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan™) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells

Pharmacological Research, 2007
Lignans are plant polyphenols which may possess anticancer, antioxidant, antimicrobial, anti-inflammatory and immunomodulatory activities. In particular, the lignan 7-hydroxymatairesinol (HMR/lignan, HMR) is a novel precursor of the mammalian lignan enterolactone (EL).
COSENTINO, MARCO, MARINO, FRANCA, FERRARI, MARCO, RASINI, EMANUELA, BOMBELLI, RAFFAELLA MARIA, LUINI, ALESSANDRA CHIARA, LEGNARO, MASSIMILIANO, CANNE MG, LUZZANI M, CREMA F, PARACCHINI S, LECCHINI, SERGIO   +11 more
openaire   +3 more sources

Convenient Preparation and Spectroscopic Characterization of 7R-Hydroxymatairesinol

Molecules, 2021
Daniele Passarella
exaly  

COMPOSITION COMPRISING 7-HYDROXYMATAIRESINOL

2022
PACCHETTI BARBARA, BLANDINI FABIO, SIANI FRANCESCA   +2 more
openaire   +1 more source