Results 21 to 30 of about 204,910 (266)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Access to sources of stable, sustainable, and modern energy as a goal of sustainable development in the European Union: Are the Scandinavian countries leading the energy transition?

Entrepreneurial Business and Economics Review
Objective: The objective of the article is to classify European Union (EU) member states according to similarity in the area of sustainable development goal 7 (SDG7) of the United Nations (UN) Agenda 2030 on affordable and clean energy ...
Krzysztof Adam Firlej, Chrystian Firlej, Lidia Luty   +2 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Contributions of artificial intelligence and digitization in achieving clean and affordable energy

Intelligent Systems with Applications
Concerned by the continuous decline in the quality of life, poverty, environmental degradation, and escalated war and conflicts, the United Nations in 2015 instituted the 17 Sustainable Development Goals (SDGs) and 169 targets.
Omojola Awogbemi, Daramy Vandi Von Kallon, K. Sunil Kumar   +2 more
doaj   +1 more source

THE (MISSING) ROLE OF NUCLEAR ENERGY IN THE SUSTAINABLE DEVELOPMENT GOALS

Journal of Multidisciplinary Studies in Human Rights and Science, 2022
Nuclear science and technology are used in many countries to help meet development objectives in areas including energy, human health, food production, water management and environmental protection.
Zion Lights
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Unravelling the impact of clean energy on the tourism sector of the stock market: Evidence from quantile granger causality and wavelet coherence analysis

International Review of Economics & Finance
The widespread use of clean energy is crucial to achieving sustainable development goal 7, while potentially impacting the tourism sector. This study aims to explore the influence of clean energy on tourism stock markets in China, Europe, and the United ...
Yiwei Wang, Zhaoyang Sun, Chao Feng, Ran Wu, Jiale Yan   +4 more
doaj   +1 more source

Supply Considerations for Scaling Up Clean Cooking Fuels for Household Energy in Low‐ and Middle‐Income Countries

GeoHealth, 2019
Promoting access to clean household cooking energy is an important subject for policy making in low‐ and middle‐income countries, in light of urgent and global efforts to achieve universal energy access by 2030 (Sustainable Development Goal 7).
E. Puzzolo, H. Zerriffi, E. Carter, H. Clemens, H. Stokes, P. Jagger, J. Rosenthal, H. Petach   +7 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source