Results 41 to 50 of about 3,610,239 (308)

Ovarian Stem Cells for Women’s Infertility: State of the Art

Biomedicines
Today, women’s infertility is considered a social disease in females, occurring not only as an effect of POF (premature ovarian failure) but also as CTRI (cancer treatment-related infertility) in oncologic patients.
Krzysztof Grettka, Katarzyna Idzik, Katarzyna Lewandowska, Ksena Świętek, Simone Palini, Franco Silvestris   +5 more
doaj   +1 more source

Organic Cultivation of Tomato in India with Recycled Slaughterhouse Wastes: Evaluation of Fertilizer and Fruit Safety

Agriculture, 2015
Environmental and health safety of recycled slaughterhouse wastes-derived fertilizer and the produce obtained through its application is not well understood.
Malancha Roy, Rimi Das, Amit Kundu, Sanmoy Karmakar, Satadal Das, Pradip Kumar Sen, Anupam Debsarcar, Joydeep Mukherjee   +7 more
doaj   +1 more source

Experimental study of the fluctuation theorem in a nonequilibrium steady state [PDF]

, 2015
The fluctuation theorem (FT) quantifies the probability of second law violations in small systems over short time scales. While this theorem has been experimentally demonstrated for systems that are perturbed from an initial equilibrium state, there are ...
Carberry, David, Evans, Denis, Reid, James, Sevick, Edith M, Wang, Genmiao, Williams, David   +5 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Girassol ornamental: caracterização, pós-colheita e escala de senescência Ornamental sunflower: characterization, postharvest and senescence scale

Revista de Ciências Agrárias, 2012
O girassol ornamental amplia o mercado de comercialização de plantas ornamentais no Brasil. Desta forma, este trabalho teve como objetivo apresentar uma caracterização do manejo pós-colheita e propor uma escala de senescência da cultura do girassol ...
Gilberto Luiz Curti, Thomas Newton Martin, Marlene de Lurdes Ferronato, Giovani Benin   +3 more
doaj  

Generation of Maize 5-Enolpyruvylshikimate-3-Phosphate Synthase (EPSPS) Variants with Improved Glyphosate Tolerance

International Journal of Plant Biology
Glyphosate (N-phosphonomethylglycine) is a broad-spectrum, foliar-applied herbicide that inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in plants.
Stephen M. G. Duff, Lei Shi, Shirley Guo, Erin Hall, Steven Voss, Oscar Sparks, Guillermo A. Asmar-Rovira, Clayton T. Larue, Marguerite J. Varagona   +8 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Going through Rough Times: from Non-Equilibrium Surface Growth to Algorithmic Scalability [PDF]

, 2001
Efficient and faithful parallel simulation of large asynchronous systems is a challenging computational problem. It requires using the concept of local simulated times and a synchronization scheme.
Guclu, H., Korniss, G., Novotny, M. A., Rikvold, P. A., Toroczkai, Z.   +4 more
core   +3 more sources