Results 21 to 30 of about 739,818 (260)

Design and Synthesis of Aminopyrimidinyl Pyrazole Analogs as PLK1 Inhibitors Using Hybrid 3D-QSAR and Molecular Docking

open access: yesPharmaceuticals, 2022
Cancer continues to be one of the world’s most severe public health issues. Polo-like kinase 1 (PLK1) is one of the most studied members of the polo-like kinase subfamily of serine/threonine protein kinases.
Swapnil P. Bhujbal   +3 more
doaj   +1 more source

Identification of the neighborhood and CA rules from spatio-temporal CA patterns [PDF]

open access: yes, 2003
Extracting the rules from spatio-temporal patterns generated by the evolution of cellular automata (CA) usually produces a CA rule table without providing a clear understanding of the structure of the neighborhood or the CA rule.
Billings, S.A., Yang, Y.X.
core   +1 more source

Determination Methods Of Defrosted Protein-vegetable Mixtures Parameters Development [PDF]

open access: yes, 2018
The aim of the work is to develop methods of investigating the influence of semolina and extruded semolina on quality and quantity parameters of mixtures with milk-protein concentrates in a cycle of freezing-defrost that allows to substantiate resource ...
Chepel, N. (Natalia)   +7 more
core   +2 more sources

Nonlinear Rheology of Unentangled Polymer Melts Reinforced with High Concentration of Rigid Nanoparticles

open access: yesNanoscale Research Letters, 2010
A scaling model is presented to analyze the nonlinear rheology of unentangled polymer melts filled with high concentration of small spherical particles.
Sarvestani Alireza
doaj   +1 more source

The LPAR1 antagonist, PIPE-791 produces antifibrotic effects in models of lung fibrosis

open access: yesRespiratory Research
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive form of interstitial lung disease (ILD) characterized by significant extracellular matrix deposition, alveolar damage, and tissue remodeling.
Michael Poon   +13 more
doaj   +1 more source

Doxycycline Enhances Survival and Self-Renewal of Human Pluripotent Stem Cells

open access: yesStem Cell Reports, 2014
We here report that doxycycline, an antibacterial agent, exerts dramatic effects on human embryonic stem and induced pluripotent stem cells (hESC/iPSCs) survival and self-renewal. The survival-promoting effect was also manifest in cultures of neural stem
Mi-Yoon Chang   +7 more
doaj   +1 more source

Uninsured and Dying Because of It: Updating the Institute of Medicine Analysis on the Impact of Uninsurance on Mortality [PDF]

open access: yes, 2008
The absence of health insurance creates a range of consequences, including lower quality of life, increased morbidity and mortality, and higher financial burdens.
Stan Dorn
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Updated Mass, Eccentricity, and Tidal Heating Constraints for the Earth-sized Planet LP 791-18 d

open access: yesThe Astronomical Journal
LP 791-18 d is a temperate Earth-sized planet ( R _P = 1.03 R _⊕ , P = 2.76 days) orbiting a late M dwarf, with an interior super-Earth (LP 791-18 b, R _P = 1.2 R _⊕ , P = 0.95 days) and an exterior sub-Neptune (LP 791-18 c, R _P = 2.5 R _⊕ , P = 4.99 ...
Michael Greklek-McKeon   +7 more
doaj   +1 more source

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