Results 81 to 90 of about 1,780 (186)

Activation of 5-HT1A Receptors Normalizes the Overexpression of Presynaptic 5-HT1A Receptors and Alleviates Diabetic Neuropathic Pain. [PDF]

Int J Mol Sci, 2023
Munawar N, Bitar MS, Masocha W.
europepmc   +1 more source

New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors

, 1993
The potential interaction of the new methoxy-chroman derivatives: (+/-)-S 20244 (4-[N-(5-methoxy-chroman-3-yl)N-propylamino]butyl-8-azaspiro- (4,5)-decane-7,9-dione) and its enantiomers (+)-S 20499 and (-)-S 20500 with central 5-hydroxytryptamine1A (5 ...
Lanfumey, L., Gozlan, H., Hajdahmane, S., Kidd, Emma Jane, Fattaccini, C. M., Guardiola-Lemaitre, B., Hamon, M., Jolas, T.   +7 more
core  

Pharmacodynamic and Pharmacokinetic Studies in Rats of S-8-(2-Furyl)- and R-8-Phenyl-2-(di-n-Propylamino)Tetralin, Two Novel 5-HT1A Receptor Agonists In-vitro with Different Properties In-vivo

, 1997
R- and S-8-(2-Furyl)- and R- and S-8-phenyl-2-(di-n-propylamino)tetralins (R- and S-LY-55 and R- and S-LY-49, respectively), novel enantiopure dipropylaminotetralins, have been screened as 5-HT1A receptor ligands.
Hong Yu, Hong B Li, Ye Liu, Uli Hacksell, Arnold R Martin, Tommy Lewander   +5 more
core   +1 more source

Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopaminergic system

, 1995
Systemic administration of the putative selective D3 receptor agonist 7-hydroxy-2-(N,N-di-n-propylamino)tetralin (7-OH-DPAT) consistently decreased extracellular dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens and ...
COLLU, MARIA, PISTIS, MARCO, Muntoni AL, Gessa GL, DEVOTO, PAOLA, Serra G, Diana M.   +6 more
core   +1 more source

PRESENCE OF SEROTONIN(1A) (5-HT1A) RECEPTOR MESSENGER-RNA WITHOUT BINDING OF [H-3] 8-OH-DPAT IN PERIPHERAL-BLOOD MONONUCLEAR-CELLS

, 1995
The authors investigated the presence of serotonin receptor type 1A (5-HT1A) as labeled by the specific ligand H-3-8 hydroxy-2-(di-N-propylamino)tetralin (H-3-8-OH-DPAT) in saturation experiments, and the expression of the mRNA encoding them, in human ...
Cassano G.B., GIANNACCINI, GINO, DALCANTO B, NARDI, IRMA, LADINSKY H, MARAZZITI D, Gino G, PALEGO, LIONELLA, CASSANO GB, PASQUALETTI, MASSIMO, ROTONDO A, LUCACCHINI, ANTONIO, Palego L, Dal Canto B   +13 more
core   +1 more source

Dopaminergic 2-aminotetralins: Affinities for Dopamine D2-receptors, Molecular Structures, and Conformational Preferences

, 1986
A combination of X-ray crystallography, NMR spectroscopy, and molecular mechanics (MMP2) calculations was used to determine the three-dimensional structures and conformational preferences of the enantiomers of 5-hydroxy-2-(di-n-propylamino)tetralin and ...
HACKSELL, U, Karlén, A., JOHANSSON, AM, KENNE, L, Sundell, S., GROL, CJ, Kenne, L., Grol, Cor J., KARLEN, A, Hacksell, U., Johansson, A. M., SUNDELL, S   +11 more
core   +1 more source

Involvement of hypothalamic serotonin in activation of the sympathoadrenomedullary system and hypothalamo-pituitary-adrenocortical axis in male Wistar rats

, 1991
Infusion of the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) (2.5-20 µg in 1 µl during 15 min), into the paraventricular nucleus of the hypothalamus (PVN) in the rat dose dependently increased plasma adrenaline and ...
Duin, Solita van,, Koolhaas, Jaap M.,, Bouws, Gerdien A.H.,, Koolhaas, Jaap M., Bohus, Béla,, Korte, S. Mechiel, van Duin, Solita, Korte, S. Mechiel,, Bouws, Gerdien A.H., Bohus, Bela   +9 more
core   +1 more source

Effects of chronic paroxetine pretreatment on (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin induced c-fos expression following sexual behavior.

, 2005
Contains fulltext : 47657.pdf (Publisher’s version ) (Closed access)Chronic treatment with the selective serotonin reuptake inhibitor paroxetine impairs the functioning of 5-HT(1A) receptors involved in ejaculation.
Waldinger, M. D., Olivier, B., Pattij, T., Dederen, P. J.W.C., Veening, J. G., Dederen, P.J.W.C., Cools, A.R., De Jong, T. R., Jong, T.R. de, Veening, J.G., Cools, A. R., Waldinger, M.D.   +11 more
core   +1 more source

Stimulation of serotonin-1A receptors in mammals to alleviate motion sickness and emesis induced by chemical agents

, 1990
A method for the alleviation of both motion sickness and chemically-induced emesis is provided which includes the administration of a nontoxic, therapeutically effective amount of a composition which stimulates serotonin-1A receptors in a mammal in need ...
Lucot, James B., Crampton, George H.
core  

Serotonin and 8-OH-DPAT reduce excitatory transmission in rat hippocampal area CA1 via reduction in presumed presynaptic Ca2+ entry

, 1995
The effect of 5-HT and its 1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) on excitatory transmission in CA1 pyramidal cells was studied.
Empson, R.M., Heinemann, U., Schmitz, D.
core   +1 more source