Results 41 to 50 of about 4,455,241 (287)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Clinical validation of the Hilab lens for AI supported point of care CBC testing in pediatric oncology

Communications Medicine
Background Complete blood count (CBC) testing is critical for diagnosing and monitoring hematological conditions, including leukemia. However, conventional analyzers require specialized infrastructure and trained personnel, limiting access in resource ...
Aléxia Thamara Gasparin, Claudiane Isabel Franco Araujo, Raphaela Rodrigues de Faria, Ivan Lucas Reis Silva, Bruno Ribeiro Medeiros, Luis Felipe Hartmann, João Victor Predebon, Bruna Hammerschmitt Gelain, Thaina Caldeiras Watanabe, Olair Carlos Beltrame, Robson de Castro Coelho, Bernardo Montesanti Machado de Almeida, Sergio Renato Rogal Júnior, Marcus Vinícius Mazega Figueredo   +13 more
doaj   +1 more source

Crystal structure of posnjakite formed in the first crystal water-cooling line of the ANSTO Melbourne Australian Synchrotron MX1 Double Crystal Monochromator

Acta Crystallographica Section E: Crystallographic Communications, 2020
Exceptionally large crystals of posnjakite, Cu4SO4(OH)6(H2O), formed during corrosion of a Swagelock(tm) Snubber copper gasket within the MX1 beamline at the ANSTO-Melbourne, Australian Synchrotron.
Stuart Mills, Jun Aishima, David Aragao, Tom Tudor Caradoc-Davies, Nathan Cowieson, Christine L. Gee, Daniel Ericsson, Stephen Harrop, Santosh Panjikar, Kate Mary Louise Smith, Alan Riboldi-Tunnicliffe, Rachel Williamson, Jason Roy Price   +12 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

جداسازی و شناسایی مولکولی و الگوی حساسیت آنتی‌بیوتیک رودوکوکوس‌های جدا شده از بیماران مبتلا به سرطان در شیراز [PDF]

مجله دانشکده پزشکی اصفهان
مقاله پژوهشی مقدمه: شیوع عفونت‌های فرصت‌طلب، مانند عفونت‌های ناشی از گونه‌های رودوکوکوس، یک مسأله‌ی مهم در افراد دارای نقص ایمنی، به‌ویژه بیماران مبتلا سرطان است.
راضیه هلالی پرگالی, مجید باصری صالحی, نیما بهادر   +2 more
doaj   +1 more source

Assessment of livelihood wellbeing and empowerment of hill women through Farmers Producer Organization: A case of women based Producer Company in Uttarakhand

The Indian Journal of Agricultural Sciences, 2020
Hill agriculture is different from agriculture at plains, in respect to land type, altitude and climate, in addition to lack of infrastructure and fragmented land holding.
Anirban mukherjee, premlata singh, satyapriya satyapriya, shantanu rakshit, rajarshi roy burman, kumari shubha, shiv kumar   +6 more
doaj   +1 more source

Evaluation of the whanau carers training programme delivered by LIFE Unlimited [PDF]

, 2004
In response to the needs of Maori informal carers, a training programme was developed for whanau carers in the Waikato region. It was delivered by LIFE Unlimited.
Ashwell, Allanah, Ridley, Sally Fenwick, Thompson, Keri   +2 more
core   +1 more source

Writing in Britain and Ireland, c. 400 to c. 800 [PDF]

, 2012
No abstract ...
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Walther, Ward, Ward, Ward, Warren, Watt, Webb, Webster, Webster, Webster, Webster, Wehlau, Wenisch, Weston, Whalen, Whatley, White, Whitelock, Whitelock, Whitelock, Whitelock, Whitelock, Whitelock, Whitelock, Whitelock, Whitelock, Whitelock, Wickersheimer, Wieland, Wilcox, Wiley, Williams, Williams, Williams, Williamson, Williamson, Wilmart, Wilson, Winterbottom, Winterbottom, Winterbottom, Winterbottom, Winterbottom, Wiseman, Wogan-Browne, Wogan-Browne, Wogan-Browne, Wolf, Wolfram, Wollmann, Wood, Woolf, Woolf, Woolf, Woolf, Wormald, Wormald, Wormald, Wormald, Wormald, Wormald, Wormald, Wormald, Wormald, Wormald, Wormald, Wrenn, Wright, Wright, Wright, Yorke, Yu, Zink, Ziolkowski, Zupitza, Æthelweard, Æthelwulf, Ó Cróinín, Ó Cróinín, Ó hAodha, Ó hUiginn, Ó Néill, Ó Néill, Ó Riain, Ó Riain, Ó Carragáin, Ó Carragáin, Ó Cathasaigh, Ó Cathasaigh, Ó Cathasaigh, Ó Cathasaigh, Ó Cathasaigh, Ó Cathasaigh, Ó Concheanainn, Ó Concheanainn, Ó Corráin, Ó Corráin, Ó hAodha   +1241 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source