FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Interval Running Exercise Reduces Running TIME of 800 Meters Dash Without Causing Increased Level of Sgot – Sgpt in Male Students of the Faculty of Sports Sciences, Manado State University [PDF]
, 2009 The effort to gain best achievement in sports by means of exercise has twodilemmatic sides, both for the coaches and sport promoters. On one side, exercise shouldbe done intensely and maximally, but on the other side, it is a known fact that excessiveand
Galatang, A. (Alprodit) +3 more
core
A prospective study of mortality from cryptococcal meningitis following treatment induction with 1200 mg oral fluconazole in Blantyre, Malawi. [PDF]
, 2014 OBJECTIVE: We have previously reported high ten-week mortality from cryptococcal meningitis in Malawian adults following treatment-induction with 800 mg oral fluconazole (57% [33/58]).
Allain, TJ +10 more
core +6 more sources
Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe
FEBS Open Bio, EarlyView.Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley +1 more source
Cytologic characteristics of adenoid cystic carcinoma of the cervix uteri: case report [Citološke karakteristike adenoid cističnog karcinoma vrata maternice: prikaz slučajeva] [PDF]
, 2010 Adenoid cystic carcinoma is a rare malignancy, usually found in the salivary glands, although this unusual tumor can be found at other sites of the body.
Babić, Damir +6 more
core
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
Transmedial (R)Evolution: {SinOsc.ar(400, 800, 0, 0.1)multisensory.experience}.play;
INSAM, 2020 The digital revolution and technology has led us towards a more intimate understanding of the acoustic instrument and its sound. What was the modern piano for Chopin was a tape recorder for Schaeffer. Today, there is little distinction between the sounds
Marija Mitrović
doaj +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Femtosecond Pump-Probe Diagnostics Of Preformed Plasma Channels [PDF]
, 2004 We report on recent ultrafast pump-probe experiments 28 in He plasma waveguides using 800 nm, 80 fs pump pulses of 0.2 x 1018 W/cm2 peak guided intensity, and single orthogonally-polarized 800 nm probe pulses with similar to0.1% of pump intensity.
Debus, A. +5 more
core +1 more source
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source