Altered Dopamine Metabolism and Response to Treatment with Levodopa/Carbidopa in MCT8 Deficiency
Movement Disorders, EarlyView.Abstract Background Allan‐Herndon‐Dudley syndrome (AHDS)/monocarboxylate transporter 8 (MCT8) deficiency is a rare X‐linked encephalopathy caused by SLC16A2 variants, impairing thyroid hormone (TH) transport into the brain. This leads to early central nervous system (CNS) TH deficiency, affecting brain maturation.
Fabio Bruschi +12 more
wiley +1 more source
In Situ Incorporation of Macromolecules in Zr-MOF Membranes for Separation of Organic Azeotropic Mixtures. [PDF]
Chem Bio EngLi L +7 more
europepmc +1 more source
Finding Maximum Weight 2‐Packing Sets on Arbitrary Graphs
Networks, EarlyView.ABSTRACT A 2‐packing set for an undirected, weighted graph G=(V,E,w)$$ G=\left(V,\kern0.3em E,\kern0.3em w\right) $$ is a subset 𝒮⊆V such that any two vertices v1,v2∈𝒮 are not adjacent and have no common neighbors. The Maximum Weight 2‐Packing Set problem that asks for a 2‐packing set of maximum weight is NP$$ \mathbf{NP} $$‐hard. Next to 13 novel data
Jannick Borowitz +2 more
wiley +1 more source
Establishment of RpHluorin2-expressing cell and its application in monitoring JTC-801-induced alkaliptosis via multi-dimensional fluorescence detection approaches. [PDF]
Front Cell Dev BiolGuo J +5 more
europepmc +1 more source
On Calculation of the Extended Gini Coefficient. [PDF]
The conventional formula for estimating the extended Gini coefficient is a covariance formula provided by Lerman and Yitzhaki (1989). We suggest an alternative estimator obtained by approximating the Lorenz curve by a series of linear segments.
Chotikapanich, D., Griffiths, W.
core
People and Nature, EarlyView.Abstract Protected areas represent complex social‐ecological systems that require governance and management approaches that valorise and enhance positive relationships between people and nature. This study analyses the alignment between social and ecological systems to detect the social‐ecological fit of projects focused on biodiversity conservation ...
Elena Andriollo +4 more
wiley +1 more source
Cortico-Striatal-Midbrain Circuit Dysregulation Underlying MK-801 Induced Impulsivity and the Ameliorative Effects of SEP. [PDF]
Adv Sci (Weinh)Wang X +6 more
europepmc +1 more source
Biodiversity science is improved when silent herbaria speak
PLANTS, PEOPLE, PLANET, EarlyView.Herbaria in the Global South are critical yet underutilized resources for biodiversity science and often absent from international databases and research networks. We highlight the phenomenon of “silent herbaria” using Nigeria as a case study and quantify how these collections fill important gaps in global biodiversity knowledge.
Daniel A. Zhigila +38 more
wiley +1 more source
A unique inhibitor conformation selectively targets the DNA polymerase PolC of Gram-positive priority pathogens. [PDF]
Nat CommunUrem M +10 more
europepmc +1 more source